PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Kcnma1 Pik3r4 20114047 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G Gja1 Pik3r4 24705551 dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nrbf2 Pik3r4 24849286 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Uvrag Pik3r4 23332761 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg14 Pik3r4 23332761,24849286 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3c3 Pik3r4 23332761,24849286 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Becn1 Pik3r4 23332761,24849286,19270693 innatedb,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r4 Aco2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab8a Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gosr1 Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r4 Copg2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa4 Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr2 Pik3r4 ortho G Grb2 Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Apc Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r4 Napa ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r4 Snw1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kiaa0226 Pik3r4 ortho Tex261 Pik3r4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec23a Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhag Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ntn1 Pik3r4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Fgfr1op Pik3r4 ortho Rab7a Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Reep2 Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Xpo1 Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r4 Chmp4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zdhhc17 Pik3r4 ortho Adam19 Pik3r4 ortho G G G G G G G G G G G G G G G G G G G G G G G Pik3r4 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec22b Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab1A Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r4 Tenm2 ortho P G G G G G G Shc1 Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r4 Chmp1b2 ortho P Rab11a Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vcp Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mov10 Pik3r4 ortho G G G G G G G G G G G G G G G G G G G G Rab6a Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp2c1 Pik3r4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mapre1 Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdkn3 Pik3r4 ortho Atp9b Pik3r4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r4 Pard6a ortho G G G G G G G G G G G G G G G G G G G G G G G G Pik3r4 Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r4 Ywhab ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r4 Csnk1d ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r4 Chmp2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Krit1 Pik3r4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab5b Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Ntrk1 Pik3r4 ortho Pik3r4 Xrcc3 ortho Jade2 Pik3r4 ortho Gnai2 Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp5c Pik3r4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8VD65 affinity chromatography technology 20114047 physical association X 2 Q8VD65 anti bait coimmunoprecipitation 24705551 - C 4 Q8VD65 P23242 anti bait coimmunoprecipitation 24705551 physical association X 2 Q8VD65 P23242 anti bait coimmunoprecipitation 24705551 physical association X 2 Q8VD65 P23242 anti bait coimmunoprecipitation 24705551 physical association X 2 Q8VD65 anti bait coimmunoprecipitation 24705551 - C 5 Q8VD65 anti bait coimmunoprecipitation 20114047 association C 22

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8VD65 Q8CDJ3 PIK3R4 ATG14 0.21 23332761 Q8VD65 Q8K245 PIK3R4 UVRAG 0.21 23332761 Q8VD65 O88597 PIK3R4 BECN1 0.21 23332761 Q8VD65 Q6PF93 PIK3R4 PIK3C3 0.21 23332761 Q8VD65 Q08460 PIK3R4 KCNMA1 0.236 20114047