PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus 3222402P14Rik Inppl1 19825976 biogrid exp P Inppl1 Ppp2r1a 19825976 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Sh2b2 17620296 biogrid exp, ortho G G G G G G Shc1 Inppl1 20697350,14502564 biogrid,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Itsn1 18692052 mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Sorbs3 16302969 mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Inpp5d ortho G G G G G G G G G G G G G G G G G G G G G G Ar Inppl1 ortho G G G G G G G G G G G G G G G G Inppl1 Rrm2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Flnc ortho GP G G G G G G G G G G Inppl1 Pcyt2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Plin5 ortho G G G G G G G G G Ddx5 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Lrba ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Krt17 ortho P G Inppl1 Gab1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Blood vessel epicardial substance, Processing of 1, ribonuclease P/MRP family, (S. cerevisiae) ortho Inppl1 Zcchc8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rplp0 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r1 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Eef1g ortho P Inppl1 Krt5 ortho GP G G G G G G G G Efna1 Inppl1 ortho G G G G G G G G G G G G G G G G G G G G G G Inppl1 Gtf2i ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Krt14 Inppl1 ortho GP G G G G G G Inppl1 Wwox ortho G G G G G G G G G G G G G G G G G G G G Ddx6 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppm1a Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp4r2 Inppl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csf1r Inppl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Lsm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa8 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Sh3kbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Epha1 Inppl1 ortho G G G G G G G G G G G Itga4 Inppl1 ortho G G G G Sorbs1 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Rps19 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r2 Inppl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Iqgap1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Bhmt2 ortho G G Rrm2 Inppl1 ortho G G G G G G G G G G G G G G G G G G G G G G Met Inppl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Ampd2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Bcr ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa9 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Krt1 Inppl1 ortho P G G G G G G G G Inppl1 Mlf2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lrrk1 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G Cd4 Inppl1 ortho G G Cbl Inppl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Krt79 ortho GP G G G G G Insr Inppl1 ortho P G G Slc2a4 Inppl1 ortho G G G G G G G G G G G G G G G G G G G G Hsp90ab1 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Alkbh3 ortho P Cct3 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpp30 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Nck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Abi1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mccc2 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G Inppl1 Gtf2a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mcm4 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Krt73 Inppl1 ortho P Egfr Inppl1 ortho GP G G G G G G G G G G G G G G G G G Abl1 Inppl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epha2 Inppl1 ortho G G G G G G G G G G G G G G G G G G Inppl1 Xpo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa1l Inppl1 ortho P G G G Inppl1 Tubb3 ortho P G G G G G G G G G G Inppl1 Ubash3b ortho Tubb5 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Grb2 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Krt16 ortho P G G Slc25a5 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tubb4b Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Plek2 ortho G G G G G G G G G G G G Tuba1b Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Tubb2b ortho GP G G G G G G G G G G G G G G G G G G G G Hspa5 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Acaca Inppl1 ortho GP G G G G Inppl1 Kif15 ortho P Inppl1 Hnrnpu ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Pccb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eef1a1 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Epb41l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Ddx3x Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vcam1 Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Myzap Inppl1 ortho GP G G G G G G G G G G G G G G G G G G Ubc Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Hid1 ortho P G G G G G G G G G G G G G G G G G G G G Bcar1 Inppl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Src Inppl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Crk Inppl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inppl1 Tubb6 ortho GP G G G G G G G G G G G G G G G G G G G G G Ntrk1 Inppl1 ortho Inppl1 Xk ortho G G G G Inppl1 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fcgr2 Inppl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6P549 affinity chromatography technology 21725061 physical association X 2 Q6P549 Q9JID9 affinity chromatography technology 17620296 physical association X 2 Q6P549 B2RXC8 affinity chromatography technology 19825976 physical association X 2 Q6P549 B2RXC8 affinity chromatography technology 19825976 physical association X 2 Q6P549 affinity chromatography technology 20697350 physical association X 2 Q6P549 affinity chromatography technology 14502564 physical association X 2 Q76MZ3 Q6P549 affinity chromatography technology 19825976 physical association X 2 Q6P549 pull down 20697350 association C 16 Q6P549 Q9R1Z8 anti bait coimmunoprecipitation 16302969 physical association X 2 Q6P549 pull down 20697350 association C 7 Q6P549 A8K3M3 pull down 18515860 physical association X 2 Q9Z0R4-2 Q6P549 anti bait coimmunoprecipitation 18692052 physical association X 2 Q9Z0R4-2 Q6P549 anti bait coimmunoprecipitation 18692052 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Inppl1 Sorbs3 MI:0018(two hybrid) 16302969 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_167551 prey bait Inppl1 Itsn1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692052 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|MI:0471(mint)|MI:0471(mint) UniProt_169808|UniProt_169809|MINT_66798|MINT_67012 bait|bait|bait|bait null|null|null|null

PPI - HINT Gene A Gene B PMID Method Quality PPP2R3A INPPL1 19825976 0004 LC SHC1 INPPL1 20697350,14502564,20697350 0004,0004,0096 LC INPPL1 PPP2R1A 19825976 0004 LC INPPL1 SH2B2 17620296 0004 LC INPPL1 SORBS3 16302969 0006 LC INPPL1 ITSN1 18692052 0006 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9JID9 Q6P549 SH2B2 INPPL1 0.21 17620296 Q9Z0R4 Q6P549 ITSN1 INPPL1 0.21 18692052 Q6P549 P98083 INPPL1 SHC1 0.472 14502564,20697350 Q9R1Z8 Q6P549 SORBS3 INPPL1 0.21 16302969 Q76MZ3 Q6P549 PPP2R1A INPPL1 0.21 19825976 Q96B97 Q6P549 SH3KBP1 INPPL1 0.126 21725061 Q6P549 P18031 INPPL1 PTPN1 0.21 18515860 Q6P549 Q38SD2 INPPL1 LRRK1 0.236 20697350