PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Rbx1 Fbxw8 16880526 biogrid exp Nanog Fbxw8 24793005 biogrid exp Fbxw8 Cul7 16880526 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw8 Skp1 16880526 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw8 Cul1 16880526 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vbp1 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc8 Fbxw8 ortho Map4k1 Fbxw8 ortho G G G G G G Myc Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G Ttc29 Fbxw8 ortho Fbxw8 Fbxo4 ortho G G G G G G G G G G G G G G G G G G G G G G G G Mapk14 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw8 Gorasp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw8 Cul2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw2 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cul4a Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddb1 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct2 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccnd1 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Irs1 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Casq2 Fbxw8 ortho G G G G G G G G G G G G G G G G Tcp1 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct7 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trip13 Fbxw8 ortho G G G G G G G G G G G G G G Cct6a Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct6b Fbxw8 ortho G G Xpo1 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw8 Skp2 ortho G G G G G G G G G G G G G Cct3 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ep300 Fbxw8 ortho Arf1 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw8 Pfdn5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw8 Bcl3 ortho G G G G G G G G G G G G G G G G G G Hsp90aa1 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw8 Rest ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw8 Nfkbia ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa4 Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8BIA4 Q9WTX6 affinity chromatography technology 16880526 physical association X 2 Q8BIA4 Q8VE73 affinity chromatography technology 16880526 physical association X 2 Q8BIA4 Q9WTX5 affinity chromatography technology 16880526 physical association X 2 Q8BIA4 P62878 affinity chromatography technology 16880526 physical association X 2 Q8BIA4 Q9WTX6 affinity chromatography technology 16880526 physical association X 2 Q8BIA4 Q8VE73 affinity chromatography technology 16880526 physical association X 2 P0CG63 Q8BIA4 pull down 21070969 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Fbxw8 Cul1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16880526 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_329048|BIOGRID_329044 prey|bait bait|prey Fbxw8 Skp1 MI:0004(affinity chromatography technology) 16880526 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_329046 bait prey Rbx1 Fbxw8 MI:0004(affinity chromatography technology) 16880526 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_329047 prey bait Fbxw8 Cul7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16880526 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_329045|BIOGRID_329052 bait|prey prey|bait

PPI - HINT Gene A Gene B PMID Method Quality RBX1 FBXW8 16880526 0004 LC NANOG FBXW8 24793005 0004 LC FBXW8 CUL7 16880526,16880526 0007,0004 LC FBXW8 SKP1 16880526 0004 LC FBXW8 CUL1 16880526,16880526 0007,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9WTX6 Q8BIA4 CUL1 FBXW8 0.376 16880526 Q8BIA4 P0CG63 FBXW8 UBI4 0.309 21070969 Q8BIA4 Q80Z64 FBXW8 NANOG 0.21 24793005 Q8BIA4 P62878 FBXW8 RBX1 0.21 16880526 Q9WTX5 Q8BIA4 SKP1 FBXW8 0.21 16880526 Q8VE73 Q8BIA4 CUL7 FBXW8 0.376 16880526