PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Rab33b Atg12 18448665 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fadd Atg12 18946037 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Atg10 Atg12 12482611 i2d,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Atg12 12665549,12482611,20723759 innatedb,biogrid,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg3 Atg12 24191030,20723759 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Atg12 12665549 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg12 Atg7 12482611 i2d,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cav1 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dhx36 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snrpb2 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Krt82 Atg12 ortho Eif3a Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eprs Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mov10 Atg12 ortho G G G G G G G G G G G G G G G G G G G G Mrps23 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tecpr1 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sf3a1 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sun2 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mcl1 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc37 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps29 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg12 Serbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx58 Atg12 ortho Epb41l5 Atg12 ortho G G G G G G G G G G G G G G G G Hnrnpab Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dock9 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc59 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map1b Atg12 ortho G G G G G G G G G G G G G G G G G G G Becn1 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wipi1 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tgm3 Atg12 ortho G G G G G Wipi2 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Crx Atg12 ortho G Sf3b1 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx6 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdfy3 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg12 Gabarap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ifih1 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Xpo1 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hnrnpul1 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Exoc4 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Clasp2 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hist1h2bc, Hist1h2be, Hist1h2bg Atg12 ortho Eif3e Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G App Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Htt Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Otud4 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg12 Plscr1 ortho G G G G G G G G G G G G G G G G G G G G G G G Atg12 Hnrnpa0 ortho Ptk2 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg12 Pop7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg12 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Aup1 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg12 Ralb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lmnb1 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl2 Atg12 ortho G G G G G G G G G G G G G G G Atg12 Rb1cc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdfi Atg12 ortho G G G Atg4b Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnmtl1 Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mavs Atg12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q61160 Q9CQY1 affinity chromatography technology 18946037 physical association X 2 Q9CQY1 O35963 affinity chromatography technology 18448665 physical association X 2 Q9CQY1 Q99J83 pull down 12482611 direct interaction X 2 Q9CQY1 Q99J83 affinity chromatography technology 12665549 physical association X 2 Q9CQY1 Q9D906 affinity chromatography technology 11890701 physical association X 2 Q9CQY1 Q9CPX6 affinity chromatography technology 24191030 physical association X 2 Q9CQY1 affinity chromatography technology 12665549 association C 3 Q9CQY1 mass spectrometry studies of complexes 12665549 association C 3 Q9CQY1 two hybrid 12665549 association C 3 Q9CQY1 coimmunoprecipitation 12665549 association C 3 Q9CQY1 Q9D906 two hybrid 12482611 physical association X 2 Q9CQY1 Q9D906 two hybrid 12482611 physical association X 2 Q9CQY1 Q99J83 biochemical 12482611 physical association X 2 Q9CQY1 Q99J83 two hybrid 12482611 physical association X 2 Q9CQY1 Q99J83 anti tag coimmunoprecipitation 20723759 physical association X 2 Q9CQY1 fluorescence microscopy 19590496 colocalization C 3 Q9CQY1 fluorescence microscopy 19590496 colocalization C 3 Q9CQY1 anti bait coimmunoprecipitation 20417604 physical association C 4 Q9CQY1 Q8R1P4 two hybrid 12482611 physical association X 2 Q9CQY1 Q8R1P4 two hybrid 12482611 physical association X 2 Q9CQY1 Q9CPX6 anti tag coimmunoprecipitation 20723759 physical association X 2 Q9CQY1 Q9CPX6 anti tag coimmunoprecipitation 20723759 physical association X 2 Q9CQY1 Q9NT62 anti tag coimmunoprecipitation 20723759 physical association X 2 Q9CQY1 Q9CPX6 anti bait coimmunoprecipitation 20723759 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Atg12 Atg7 MI:0018(two hybrid)|MI:0018(two hybrid) 12482611 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_163501|UniProt_163502 prey|bait bait|prey Atg3 Atg12 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 20723759,24191030 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact)|(intact) BIOGRID_331704|UniProt_172808|UniProt_172805|UniProt_172804 bait|bait|prey|prey prey|prey|bait|bait Atg5 Atg12 MI:0018(two hybrid)|MI:0096(pull down)|MI:0428(imaging technique)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 12482611,12665549,20723759 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(intact)|(intact) UniProt_163495|BIOGRID_323800|BIOGRID_325849|UniProt_163503|UniProt_172806 prey|prey|bait|neutral component|prey bait|bait|prey|neutral component|bait Rab33b Atg12 MI:0004(affinity chromatography technology) 18448665 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322937 bait prey

PPI - HINT Gene A Gene B PMID Method Quality ATG10 ATG12 12482611 0018 LC ATG5 ATG12 12482611,12482611,12482611 0401,0096,0018 LC ATG12 ATG7 12482611 0018 LC RAB33B ATG12 18448665 0004 LC FADD ATG12 18946037 0004 LC ATG5 ATG12 20723759,12665549,12482611,12665549,12482611,12482611 0007,0004,0401,0007,0096,0018 LC ATG3 ATG12 20723759,20723759,24191030 0006,0007,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9CQY1 Q61160 ATG12 FADD 0.21 18946037 Q9CQY1 Q8R1P4 ATG12 ATG10 0.309 12482611 Q9CQY1 O35963 ATG12 RAB33B 0.21 18448665 Q9CQY1 Q99J83 ATG12 ATG5 0.814 12482611,20723759,12665549 Q9CQY1 Q8NCE2 ATG12 MTMR14 0.126 19590496 Q9CQY1 Q9CPX6 ATG12 ATG3 0.507 20723759,24191030 Q9GZQ8 Q9CQY1 MAP1LC3B ATG12 0.126 19590496 Q9NT62 Q9CQY1 ATG3 ATG12 0.21 20723759 Q9D906 Q9CQY1 ATG7 ATG12 0.309 12482611 Q9CQY1 P42858 ATG12 HTT 0.21 20417604