PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Mycbp2 Eed 24457600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Plk4 Mycbp2 ortho G G G G G G G G G G G G G G G G G G G Cul4b Mycbp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mycbp2 Rae1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mycbp2 F-box/SPRY domain-containing protein 1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mycbp2 Def6 ortho Mycbp2 Exoc2 ortho P Mycbp2 Usp11 ortho G G G G G G G G G G G G G G G G G G G G G G Mycbp2 Ska1 ortho G G G G Ywhag Mycbp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nos2 Mycbp2 ortho G Ube3a Mycbp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tsc2 Mycbp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mycbp2 Sesn3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mycbp2 Slain2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr1d1 Mycbp2 ortho G G G G G G G G G G G G G G G G G G G G G G Mycbp2 Map1lc3a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhah Mycbp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mycbp2 Appl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tdgf1 Mycbp2 ortho Ube2d3 Mycbp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myc Mycbp2 ortho G G G G G G G G G G G G G G G G G G G G G Ywhaz Mycbp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mycbp2 Aldh1l2 ortho P Cbx4 Mycbp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc8 Mycbp2 ortho Ttn Mycbp2 ortho GP G G G G G G G G G G G G G G G G G G G G Bak1 Mycbp2 ortho G G G G G G G G G G G G G G G G G Mycbp2 Sirt7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lgr4 Mycbp2 ortho Mycbp2 Wdr48 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Clec11a Mycbp2 ortho G G G G G G G G G G G G G G G Mapk6 Mycbp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Mycbp2 Atp13a2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Casq2 Mycbp2 ortho GP G G G G G G G G G G G G G G G Srpk2 Mycbp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mycbp2 Ccdc158 ortho Mycbp2 Vps26b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mycbp2 Hdac11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Lgals3bp Mycbp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mycbp2 Med4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mycbp2 Whsc1 ortho Skap1 Mycbp2 ortho Ptch1 Mycbp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mycbp2 Rapgef2 ortho Cbx2 Mycbp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Mycbp2 Chm ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wnk1 Mycbp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc42bpa Mycbp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Sfn Mycbp2 ortho P G G G G G G G G Mycbp2 Ywhab ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ptpn12 Mycbp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mex3c Mycbp2 ortho Ube2l3 Mycbp2 ortho P Ube2d1 Mycbp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Mycbp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q7TPH6 Q63633 two hybrid 18769030 physical association X 2 Q7TPH6 Q63633 two hybrid 18769030 physical association X 2 Q7TPH6 Q63633 pull down 18769030 physical association X 2 Q7TPH6 Q63633 anti bait coimmunoprecipitation 18769030 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Slc12a5 Mycbp2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18769030 taxid:10116(Rattus norvegicus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_167911|UniProt_182495|UniProt_182494|UniProt_182496|UniProt_167914|UniProt_182493|UniProt_167912|UniProt_167913 bait|bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey|prey Mycbp2 Eed MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332684 prey bait

PPI - HINT Gene A Gene B PMID Method Quality MYCBP2 MYCBP2 20156452 0114 LC RANGAP1 MYCBP2 26304119 0004 LC RAN MYCBP2 26304119 0096 LC MYCBP2 EED 24457600 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q7TPH6 P46061 MYCBP2 RANGAP1 0.21 26304119 Q7TPH6 P62827 MYCBP2 RAN 0.309 26304119 Q96A23 Q7TPH6 CPNE4 MYCBP2 0.332 12522145 Q96FN4 Q7TPH6 CPNE2 MYCBP2 0.183 12522145 Q921E6 Q7TPH6 EED MYCBP2 0.126 24457600 Q99829 Q7TPH6 CPNE1 MYCBP2 0.332 12522145