PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Vhl Sumo1 17981124 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Tceb2 15601820 innatedb,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rbx1 23990666,15601820 innatedb,biogrid,intact exp Vhl Pard6a 17101696 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G Vhl Cul2 15601820 innatedb,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Pard3 17101696 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hif1a 12468553,20211142,17981124 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Kif3b 17825299 intact exp, ortho G G G G G G G G G G G G G G G G G Vhl Epas1 20211142 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G Vhl Tceb1 23990666,15601820 innatedb,biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Prkcz 17101696 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G Kif3a Vhl 17825299 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Kifap3 17825299 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Uxt ortho G G G G G G G G G G G G G G G G G G G G G G G G Ncl Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Cct6a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rhpn2 ortho G G G G G G G G G G G G G G G G G Vhl Acp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rbbp7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx3 Vhl ortho G G G G Vhl Crtap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Pls3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac3 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Tgfb1i1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hnrnpl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hspa4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hnrnpk ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppib Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Lancl1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Gspt1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Anxa2 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Pfdn2 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Sar1a Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Cct5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Pfdn5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Tuba1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Smarcc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hnrnpc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4a, Hist4h4 ortho G G G G G G G G G G G G Vhl Stmn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Prmt1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Fkbp1a Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rpl30 ortho Vhl Eif5a2 ortho Nedd8 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Mob4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ube2m ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rpl10a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Msh4 ortho G Polr2a Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Atp5j2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ict1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Cer1 Vhl ortho Trip12 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ube2l3 ortho Vhl Son ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Top2a ortho G G G G G G G G G G G G G G G G G G G G Vhl Ilf3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Grwd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hif1an ortho Ranbp1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ep300 Vhl ortho Vhl Osr1 ortho G G G G G G Vhl Rab2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Mrps16 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Cct7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmb5 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Plod3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Aurka ortho G G G G G G G G G G G G G Vhl Cntf ortho Vhl Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Lpp ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Nudc Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rcc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Tagln2 ortho G G G G G G G G G G G G G G G G G G G G G G G Vhl Gli1 ortho G G G Nr4a1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Rb1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ddx5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Mcts1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Myc Vhl ortho G G G G G G G G G G G G G G G G G G G G Vhl Cul3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Cycs ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Skp2 ortho G G G G G G G G G G G G Vhl Psma6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Mybbp1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Pebp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Fastkd3 ortho Vhl Ccna1 ortho G Vhl Vamp3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ddx3x ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops5 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rpl11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Vars ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Atp5o ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Diacylglycerol kinase, DAG kinase Vhl ortho Vhl Hnrnph2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Cstb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc3 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Kirrel2 ortho Vhl Psmb3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rab7a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Krtcap2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Cbx1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Cox5a Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkcd Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ssr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Mycbpap ortho G G G Vhl Hspa8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Timm17a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Col4a3 ortho G G G G Vhl Rps11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Otud7a ortho G G G G G G G G Vhl Pfn2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rnf7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Trim28 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Gdi2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Tbca ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Nup155 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Arf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rbpms ortho G G G G G G G G G G G G G G G G G G G G Vhl Eif3k ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl E2f1 ortho G G G G G Vhl Rps15a ortho Rpsa Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Nkrf ortho Vhl Qil1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Alas1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Kat2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Nob1 ortho Vhl Ireb2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ssb Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hspe1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ccar2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Mycbp ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Lepre1 ortho G G G G G G G G G G G G Rps16 Vhl ortho Vhl Mdfi ortho G G G Vhl Nudt21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Col4a6 Vhl ortho G G G G G G G G Vhl Rps19 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Txndc17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Trmt112 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Myl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Iars ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpl12 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Hnrnph1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ddx3y ortho G G G G G G G G G G G G G G G G G G G G G G G Vhl Snrnp200 ortho Vhl Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Lman1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Snrnp70 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ivns1abp ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rab1b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Pitpnb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Colgalt1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Sp1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Nr4a3 ortho Vhl Tmco1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ccdc82 ortho G G G G G G Vhl Sept2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ppp2r2b ortho G G G G G G G G G G Vhl Rab35 ortho Vhl Ccdc59 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hnrnpd ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Cab39 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Eif1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl C1qtnf2 ortho Vhl Thoc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Srp14 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Hist1h1c Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Fkbp8 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Hprt1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rps9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpl21 Vhl ortho Rplp0 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Vbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Cstf3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Jak2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Sf3a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Col9a1 ortho G G G G Vhl Eif5a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd44 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G Vhl Tpt1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ube2n ortho Tkt Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Actb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ubr5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Uqcc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rps3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ddx17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Pfas ortho Vhl Cuta ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rb1cc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Dctpp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rps6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddt Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Spry2 ortho G G G G G G G G G G G G G G G G G G G G G G G G Vhl Cbx5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ube2d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rps10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpl7a Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ube2d3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Tubb4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Dnaja2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Dcun1d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Fscn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Tcp1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Limd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Aprt Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rbbp4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rasgrp1 ortho G G G G G G G Vhl Capzb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Vapb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl2l11 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Pcgf2 Vhl ortho G G G G G Vhl Rit1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Kat2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Dgkz ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Epha4 ortho G G G G G G G Vhl Rpl5 ortho Vhl Lypla1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ezr Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Fn1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Egln1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rab11a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G C3 Vhl ortho G G G G G G G G G G G G G G G G G G G G Hdac1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hspb11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Col6a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Clu ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Sat2 ortho Vhl Capn7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec22b Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Slc3a2 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Jade1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rps27l ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rps14 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Mydgf ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Exosc8 ortho Vhl Mknk2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Vps35 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Prmt3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Mrpl14 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab5c Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ar Vhl ortho G G G G G G G G G G G G G G Vhl Heterogeneous nuclear ribonucleoprotein R, Protein Hnrnpr ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrb2 Vhl ortho G G G G G G G Vhl Ubxn7 ortho Vhl Astl ortho Vhl Cotl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmb1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Sarnp ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Atm ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Egln3 ortho G G G G G G G G G G G G G G G Vhl Atic ortho Vhl Has1 ortho G G G G Vhl 2900073G15Rik ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G App Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Tle1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Cbr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Pld1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Papss2 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Chmp2b ortho Vhl Sap130 ortho Vhl Cmc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Bsg Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G C1qb Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Mtpn ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Usp33 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Btf3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hint1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Flna ortho G G G G G G G G G G G G G G G G G G G G G G G G G G P4hb Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rpl18a ortho Vhl Kat5 ortho Vhl Kntc1 ortho Socs3 Vhl ortho G G G G G G G G G G G G G G G G G G G G G Vhl Hist1h2bc, Hist1h2be, Hist1h2bg ortho Vhl Park7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rps17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Echs1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps2 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ube2k ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Acly ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Aarsd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ankrd40 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Snx3 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Elavl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hnrnpab ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Dctn1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rps5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Kif5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rhoc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hyou1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Akr1b1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ate1 ortho G G G G G G G G G G G G G G G G G G C2 Vhl ortho G G G G G G G G G G G G G G G G Vhl Cyba ortho G G G G G G G G G G G G G G G G G G G G G G G G Vhl Glrx5 ortho Vhl Rwdd3 ortho G G G Vhl Hif3a ortho G G G G G G G G G G G G Vhl Mcm7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Sirt1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hnrnpm ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Sf3b6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rpl22 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Nr4a2 ortho G G G G G G G G G G G G G Vhl Dtymk ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Socs1 Vhl ortho Vhl Hnrnpu ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Tuba4a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Plod2 ortho G G G G G G G G G G G G G G G G G G Vhl Trafd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Fabp5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Atxn2 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ube2v1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa5 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Parp1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Gnb2l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Plp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Jmjd1c ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Cdk2 ortho G G G G G G G G G G G G G G G G G G G G G G Vhl Cul5 ortho Vhl Snrpa1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Zyx ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Prmt8 ortho Vhl Srprb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hnrnpll ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Hnrnpa2b1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Egln2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Pin1 ortho Vhl Cdo1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Vhl Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Pkd1l3 ortho Vhl Bcl2l14 ortho G G G G G G G G G G G G Vhl Ralyl ortho Vhl Set ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Mcc ortho Col4a2 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Hist1h2bf, Hist1h2bj, Hist1h2bl, Hist1h2bn Vhl ortho Vhl Ufc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Kif2c ortho G G G G G G G G G G G G Vhl Psmd13 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rpl37a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Znf512b ortho Vhl Klf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Tars ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppm1b Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Grpel1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rbpms2 ortho Vhl Chek2 ortho G G G G G G G G G G G G G G G G G G Vhl Lrrc59 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Grn Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hdac2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Itgal Vhl ortho G G G G Vhl Cct4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Pgrmc1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Malt1 ortho Eef1b Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Prdx1 Vhl ortho Vhl Cct2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rpl14 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Tceb3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Mrps23 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Supt16h ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Cct8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Atp5f1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Txn Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Slc2a1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Golga4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Hnrnpdl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Col4a1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Cct3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Cdkn2a ortho Vhl Eef1d ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Uqcrfs1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Dnaja3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Uchl1 ortho G G G G G G G G G G G G G G G G Vhl Stk38 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Mif Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Psma2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Tgm2 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Col4a5 protein, Protein Col4a5 ortho G G G G G G G G G G G G G G G G G Vhl Pcbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rpl35 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Dvl2 ortho G G G G G G G G G G G Vhl Ptpn14 ortho G Vhl Usp20 ortho G G G G G G G G G G G G G G G G G G G G G G G G Card9 Vhl ortho Vhl Rap1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rnf139 ortho Vhl Lsm12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ube2d2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab6a Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ltv1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Stk16 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkch Vhl ortho G G G G G G G G G G G G G G G G Vhl Dnaja1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Sod2 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Csnk2a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rpa3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Rab14 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Wtip ortho Vhl Ajuba ortho G G G G G G G G G G G G G G G Vhl Polr2g ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Xrcc5 Vhl ortho G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P40338 - 15369676 - X 2 P40338 - 15369676 - X 2 P83940 P40338 affinity chromatography technology 23990666 physical association X 2 P40338 affinity chromatography technology 17101696 physical association X 2 P97481 P40338 two hybrid 20211142 direct interaction X 2 Q3V341 P40338 affinity chromatography technology 17101696 physical association X 2 P40338 affinity chromatography technology 17101696 physical association X 2 P40338 two hybrid 23961993 direct interaction X 2 P40338 P62878 affinity chromatography technology 23990666 physical association X 2 Q61221 P40338 affinity chromatography technology 12468553 physical association X 2 Q61221 P40338 two hybrid 20211142 direct interaction X 2 P40338 anti bait coimmunoprecipitation 17825299 association C 4 P40338 anti bait coimmunoprecipitation 17825299 association C 4 P40338 anti bait coimmunoprecipitation 15601820 association C 5

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Vhl Tceb1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 15601820,23990666 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_331567|UniProt_164464 bait|bait prey|prey Vhl Hif1a MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 12468553,20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_313148|BIOGRID_323491 prey|prey bait|bait Vhl Prkcz MI:0004(affinity chromatography technology) 17101696 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322686 bait prey Vhl Rbx1 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 15601820,23990666 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_164464|BIOGRID_331566 bait|bait prey|prey Vhl Pard3 MI:0004(affinity chromatography technology) 17101696 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322685 bait prey Vhl Pard6a MI:0004(affinity chromatography technology) 17101696 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322684 bait prey Vhl Epas1 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313037 prey bait

PPI - HINT Gene A Gene B PMID Method Quality VHL EPAS1 20211142,15369676 0018,0047 HT,LC VHL HIF1A 20211142,15369676 0018,0047 HT,LC KIF3A VHL 17825299 0006 LC VHL TCEB2 15601820,15601820 0006,0007 LC VHL RBX1 15601820,23990666 0006,0004 LC VHL SUMO1 17981124,17981124 0096,0004 LC VHL KIFAP3 17825299 0006 LC VHL TCEB1 15601820,23990666,15601820 0006,0004,0007 LC VHL PRKCZ 17101696 0004 LC VHL HIF1A 17981124,17981124,12468553 0096,0004,0004 LC VHL KIF3B 17825299 0006 LC VHL EGLN1 26215701 0004 LC VHL PARD3 17101696 0004 LC VHL RHOBTB3 26215701 0004 LC VHL CUL2 15601820,15601820 0006,0007 LC VHL PARD6A 17101696 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q61221 P40338 HIF1A VHL 0.648 20211142,12468553,17981124 P62878 P40338 RBX1 VHL 0.309 15601820,23990666 P83940 P40338 TCEB1 VHL 0.309 15601820,23990666 Q9CTN4 P40338 RHOBTB3 VHL 0.376 26215701 P40338 P28741 VHL KIF3A 0.376 17825299 Q9UBK9 P40338 UXT VHL 0.309 23961993 P62869 P40338 TCEB2 VHL 0.126 15601820 P70188 P40338 KIFAP3 VHL 0.21 17825299 Q02956 P40338 PRKCZ VHL 0.21 17101696 Q61771 P40338 KIF3B VHL 0.21 17825299 Q91YE3 P40338 EGLN1 VHL 0.21 26215701 Q99NH2 P40338 PARD3 VHL 0.21 17101696 Q9D4H8 P40338 CUL2 VHL 0.126 15601820 Q9Z101 P40338 PARD6A VHL 0.21 17101696 P97481 P40338 EPAS1 VHL 0.183 20211142 P63166 P40338 SUMO1 VHL 0.623 17981124