PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Fancd2 Eed 24457600 biogrid exp Ubc Fancd2 21764741 biogrid exp, ortho Brca2 Fancd2 16127665 biogrid exp, ortho H2afx Fancd2 17304220 biogrid,mint,intact exp, ortho Cebpd Fancd2 20805509 biogrid exp, ortho Fancd2 Fanci 21764741 biogrid exp, ortho Fancd2 Fzr1 ortho Mdc1 Fancd2 ortho Fan1 Fancd2 ortho Aldh3a2 Fancd2 ortho Fancd2 Ca14 ortho Hnrnpd Fancd2 ortho Fancd2 Tnfsf13b ortho Fancd2 Cntrob ortho Helq Fancd2 ortho Brca1 Fancd2 ortho Rad51 Fancd2 ortho Fancd2 Rad18 ortho Fancd2 Irf2bpl ortho Fancd2 Rbbp8 ortho Fancd2 Ipo4 ortho Fancd2 Ube2t ortho Fancd2 Kat5 ortho Traf6 Fancd2 ortho Fancd2 Mlh1 ortho Men1 Fancd2 ortho Rad50 Fancd2 ortho Atm Fancd2 ortho Epha2 Fancd2 ortho Tnfrsf1b Fancd2 ortho Mre11a Fancd2 ortho Fancd2 Foxo3 ortho Faap20 Fancd2 ortho Ntrk1 Fancd2 ortho Fancd2 Cdk20 ortho Fancd2 Emc2 ortho Dnm1 Fancd2 ortho Fancd2 Yeats4 ortho Fancc Fancd2 ortho Fancd2 Bag6 ortho Fancd2 Usp1 ortho Tnks Fancd2 ortho Pigs Fancd2 ortho Cdc5l Fancd2 ortho Fancd2 Dclre1b ortho Smyd5 Fancd2 ortho Fancd2 Itgb3bp ortho Fscn1 Fancd2 ortho Fancd2 Dcp2 ortho Fancd2 Fancg ortho Kpna1 Fancd2 ortho Fancd2 Nbn ortho Jrkl Fancd2 ortho Blm Fancd2 ortho Fancd2 Polh ortho Pcna Fancd2 ortho Fancd2 Fancl ortho Myc Fancd2 ortho Ptger3 Fancd2 ortho Tnfrsf1a Fancd2 ortho Fancd2 Atr ortho Elavl1 Fancd2 ortho Terf1 Fancd2 ortho Ncam1 Fancd2 ortho Msh2 Fancd2 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q80V62 Q921E6 affinity chromatography technology 24457600 physical association X 2 Q80V62 P0CG50 x-ray crystallography 21764741 association X 2 Q80V62 Q00322 affinity chromatography technology 20805509 physical association X 2 Q80V62 P27661 affinity chromatography technology 17304220 physical association X 2 Q80V62 P27661 affinity chromatography technology 17304220 physical association X 2 Q80V62 P97929 affinity chromatography technology 16127665 physical association X 2 Q8K368 Q80V62 x-ray crystallography 21764741 association X 2 Q80V62 P27661 anti bait coimmunoprecipitation 17304220 physical association X 2 Q80V62 P27661 anti bait coimmunoprecipitation 17304220 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality UBC FANCD2 21764741 0114 LC FANCD2 FANCI 21764741 0114 LC H2AFX FANCD2 17304220,17304220 0006,0004 LC BRCA2 FANCD2 16127665 0004 LC CEBPD FANCD2 20805509 0004 LC FANCD2 EED 24457600 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8K368 Q80V62 FANCI FANCD2 0.309 21764741 Q80V62 P0CG50 FANCD2 UBC 0.309 21764741 Q80V62 P27661 FANCD2 H2AFX 0.507 17304220 Q80V62 Q00322 FANCD2 CEBPD 0.21 20805509 Q921E6 Q80V62 EED FANCD2 0.126 24457600 Q80V62 P97929 FANCD2 BRCA2 0.21 16127665