PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Vav1 Plp2 15102471 mint,intact exp G G G G G Kit Vav1 10679268 biogrid exp G G G G G Vav1 Mapk14 9064344 biogrid exp G G G G G Cd3e Vav1 9064344 biogrid exp G G Vav1 Cd247 9064344 biogrid exp G G Vav1 Foxp3 22922362 biogrid exp Ptprc Vav1 8570203 intact exp Vav1 Haus7 15102471 mint,intact exp G G G G G Vav1 Hnrnpk 7862126 mint,intact exp, ortho G G G G G Vav1 Grb2 15102471 mint,intact exp, ortho G G G G G Vav1 Sh3bp2 20439986 innatedb exp, ortho G G G G Vav1 Ptpn6 i2d exp, ortho G G G G Vav1 Fyn i2d exp, ortho G G G G G Vav1 Cblb 18227156 innatedb exp, ortho Vav1 Lcp2 i2d exp, ortho G G G G Socs1 Vav1 15456882 biogrid exp, ortho Vav1 Prkcq 18227156 innatedb exp, ortho G G G G G Vav1 Dnm2 i2d exp, ortho G G G G G Lat Vav1 ortho G G G G Vav1 Blnk ortho G G G G Vav1 Abi1 ortho G G G G G Vav1 Jak2 ortho G G G G Vav1 Apc ortho G G G G G Vav1 Siah1a ortho G G G G G Vav1 Tyk2 ortho G G G G G Vav1 Sos1 ortho Vav1 Shb ortho Cbl Vav1 ortho G G G G G Protein Arhgef5 Vav1 ortho G G G G Vav1 Crkl ortho G G G G G Vav1 Pag1 ortho G G G G G Vav1 Rhoa ortho G G G G G Aoc3 Vav1 ortho G Met Vav1 ortho G G G G Vav1 Trio ortho G G G G G Vav1 Acta1 ortho G G G G Vav1 Protein Arhgef11, Rho guanine nucleotide exchange factor (GEF) 11 ortho Vav1 Rhog ortho G G G G G Vav1 Erbb2 ortho Vav1 Notch1 ortho G G G G Vav1 Pik3cg ortho G G G G Vav1 Cdc42bpa ortho G G G G G Vav1 Sla ortho G G G G Vav1 Zyx ortho G G G G G Vav1 Ptprd ortho G G G G Vav1 Ptk2b ortho G G G G Vav1 Syk ortho G G G G Insr Vav1 ortho Vav1 Rhod ortho Vav1 Dok1 ortho G G G G Vav1 Nfkbia ortho G G G G G Vav1 Il6st ortho G G G G G Vav1 Hras ortho G G G G G Vav1 Itsn1 ortho G G G G Cd19 Vav1 ortho G G G G Lck Vav1 ortho G G G G Vav1 Nek3 ortho G G G G Tec Vav1 ortho G G G G Vav1 Arhgef7 ortho G G G G Vav1 Arhgdib ortho G G G G G Vav1 Eed ortho G G G G G Vav1 Btk ortho G G G G Itgb2 Vav1 ortho G G G G Vav1 Arhgef18 ortho G G G G G Vav1 Ptpn22 ortho G G G G Vav1 Gab1 ortho G G G G G Vav1 Racgap1 ortho G G G G G Vav1 Tuba1a ortho G G G G G Vav1 Itk ortho G G Vav1 Map2k1 ortho G G G G G Vav1 Dock2 ortho G G G G G Vav1 S100b ortho Vav1 Casp3 ortho G G G G Vav1 Tuba4a ortho G G G G G Protein Akap13 Vav1 ortho Vav1 Havcr2 ortho G G Vav1 Abr ortho G G G G Vav1 Cd28 ortho G G G Vav1 Erbb3 ortho G G G G Vav1 Suz12 ortho G G G G G Xrcc6 Vav1 ortho G G G G G Vav1 Arhgef1 ortho G G G G G Ms4a2 Vav1 ortho G G Vav1 Phax ortho G G G G G Farp1 Vav1 ortho G Vav1 Plcg2 ortho G G G G G Vav1 Vav2 ortho G Epor Vav1 ortho G G G G Vav1 Nck1 ortho G G G G G Vav1 Egfr ortho Vav1 Raf1 ortho G G G G G Vav1 Protein Zfp655, Zinc finger protein 655, Zinc finger protein 655, isoform CRA_a ortho Vav1 Crk ortho G G G G G Vav1 Mcf2l ortho Fgfr1 Vav1 ortho G G G Hck Vav1 ortho G G G G Vav1 Plcg1 ortho Emd Vav1 ortho G G G G G Vav1 Rac1 ortho G G G G G Rasgrf1 Vav1 ortho G Vav1 Arhgdia ortho G G G G G Vav1 Bcr ortho G G G G G Vav1 Khdrbs1 ortho G G G G G Vav1 Zap70 ortho G G G G G Vav1 Tubb5 ortho G G G G G Pdgfrb Vav1 ortho G G G G Pik3r1 Vav1 ortho G G G G Vav1 Cxcr4 ortho G G G G Vav1 Ezh2 ortho G G G G G Xrcc5 Vav1 ortho G G G Vav1 Dnmbp ortho G G G G G Vav1 Wipf1 ortho G G G G Vav1 Arhgef16 ortho Cd5 Vav1 ortho G G Vav1 Ctnnd1 ortho G G G G Vav1 Chuk ortho G G G G G Vav1 Shc1 ortho G G G G G Vav1 Farp2 ortho Vav1 Mertk ortho G G G G Vav1 Arhgef6 ortho Spi1 Vav1 ortho G G G G Jun Vav1 ortho G G G G Vav1 Siah2 ortho G G G G G Vav1 Akt1 ortho G G G G G Abl1 Vav1 ortho G G G G G Vav1 Prlr ortho G Vav1 Mapk1 ortho G G G G G Vav1 Itsn2 ortho G G G G Vav1 Tiam1 ortho G G G G G Ar Vav1 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O35716 P27870 biochemical 15456882 colocalization X 2 P27870 P05532 two hybrid 10679268 direct interaction X 2 P27870 P29351-3 enzymatic study 9064344 direct interaction X 2 P22646 P27870 affinity chromatography technology 9064344 physical association X 2 P47811 P27870 affinity chromatography technology 9064344 physical association X 2 Q53Z59 P27870 affinity chromatography technology 22922362 physical association X 2 Q3UU54 P27870 affinity chromatography technology 9064344 physical association X 2 A4D2P1 P27870 gdp/gtp exchange assay 18488041 direct interaction X 2 P27870 anti bait coimmunoprecipitation 22203994 physical association X 2 P27870 anti bait coimmunoprecipitation 22203994 physical association X 2 P27870 anti tag coimmunoprecipitation 22203994 physical association X 2 P27870 anti tag coimmunoprecipitation 22203994 physical association X 2 P27870 Q9R1Q7 two hybrid 15102471 physical association X 2 P61979 P27870 pull down 7862126 direct interaction X 2 P61979 P27870 coimmunoprecipitation 7862126 physical association X 2 P61979 P27870 two hybrid 7862126 physical association X 2 P27870 coimmunoprecipitation 8570203 association C 6 P03332 P27870 two hybrid 16628219 physical association X 2 P03332 P27870 two hybrid 16628219 physical association X 2 Q07666 P27870 pull down 17855053 physical association X 2 Q8BKT8 P27870 two hybrid 15102471 physical association X 2 B0LPF3 P27870 x-ray crystallography 11406576 direct interaction X 2 Q60631 P27870 two hybrid 15102471 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Vav1 Hnrnpk MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0096(pull down) 7862126 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact) UniProt_177392|MINT_78153|MINT_78154|MINT_78155|UniProt_177393|UniProt_177394 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey Vav1 Plp2 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_164975 bait prey Vav1 Haus7 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_164981 bait prey Vav1 Grb2 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_164986 prey bait

PPI - HINT Gene A Gene B PMID Method Quality SOCS1 VAV1 15456882 0401 LC KIT VAV1 10679268 0018 LC PTPRC VAV1 8570203 0019 LC VAV1 VAV1 11406576 0114 LC VAV1 PTPN6 8632004,8632004 0019,0004 LC VAV1 DNM2 15696170 0019 LC VAV1 FYN 9822663 0019 LC VAV1 HNRNPK 7862126,7862126,7862126 0018,0096,0019 LC VAV1 GRB2 15102471 0018 LC VAV1 LCP2 10026222,9064333 0019,0019 LC VAV1 HAUS7 15102471 0018 LC VAV1 PLP2 15102471 0018 LC SOCS1 VAV1 15456882 0401 LC TAL1 VAV1 19346495 0007 LC CD3E VAV1 9064344 0004 LC VAV1 CD247 9064344 0004 LC VAV1 PTPN6 8632004,8632004 0019,0004 LC VAV1 MAPK14 9064344 0004 LC VAV1 HNRNPK 7862126,7862126,7862126 0018,0096,0019 LC VAV1 FOXP3 22922362 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q60787 P27870 LCP2 VAV1 0.126 24584089 Q61003 P27870 CD6 VAV1 0.126 24584089 P27870 O54957 VAV1 LAT 0.126 24584089 P27870 O35716 VAV1 SOCS1 0.126 15456882 Q8BKT8 P27870 HAUS7 VAV1 0.183 15102471 P27870 P05532 VAV1 KIT 0.309 10679268 P27870 P06800 VAV1 PTPRC 0.21 8570203 Q3U1F9 P27870 PAG1 VAV1 0.236 26512138 P61979 P27870 HNRNPK VAV1 0.623 7862126 Q99JB6 P27870 FOXP3 VAV1 0.126 22922362 P27870 P03332 VAV1 GAG 0.523 16628219 P27870 P22646 VAV1 CD3E 0.21 9064344 Q07666 P27870 KHDRBS1 VAV1 0.21 17855053 P27870 P24161 VAV1 CD247 0.21 9064344 P47811 P27870 MAPK14 VAV1 0.21 9064344 Q60631 P27870 GRB2 VAV1 0.183 15102471 Q9R1Q7 P27870 PLP2 VAV1 0.183 15102471 P62993 P27870 GRB2 VAV1 0.309 11406576 P63000 P27870 RAC1 VAV1 0.309 18488041