PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Siah2 Spry1 16888801 biogrid exp G G G G G G G G G G G G G G G G G G G G Thrb Siah2 21389087 biogrid exp G G G G G Siah2 Ngfr 22055192 biogrid exp G G G G G Thra Siah2 21389087 biogrid exp G G G G G G G G G G G G G G G G G G G G G Siah2 Spry4 16888801 biogrid exp G Pparg Siah2 22294748 biogrid exp G G G G G G G G G G G G G G Siah2 Ncor1 21389087,22294748 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G Akap1 Siah2 18323779 mint,intact exp, ortho G G G G G G G G G G G G G G G G G Siah2 Spry2 16888801 biogrid exp, ortho G G G G G G G G G G G G G G G G G G Siah2 Sh3rf1 16230351 intact exp, ortho G G G G G G G G G G G G G G Siah2 Egln3 i2d exp, ortho G G G G G G G G G G G G G Siah2 Plce1 17998205 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G Dbi Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Tinf2 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Pml ortho G G G G G G G G G G G G G G G G G G G Cebpd Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Dld Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Ndrg1 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Tp53bp2 ortho Siah2 Hipk3 ortho G G G G G G G G G G G G G G G G G G G G G Eef1d Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Myd88 Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Dhcr24 ortho G G G G G G G G G G G G G G G G G G G G Siah2 Ccbe1 ortho Nkx3-1 Siah2 ortho G Siah2 Ski ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Tyk2 ortho G G G G G G G G G G G G G G G G G G G G G Ube2i Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Egln1 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Peg10 ortho G Siah2 Ppp1r13b ortho Pias1 Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Siah1a Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Atn1 Siah2 ortho G G G G G G G G G G G G G G G G G Siah2 Pias2 ortho G G G G G G G G G G G G G G G G G G G G G Pias3 Siah2 ortho G G G G G G G G G G G G G G G G G G G G Siah2 Cacybp ortho G G G G G G G G G G G G G G G G G G G G G Ppp1cc Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Syp ortho G G G G G G Hdac3 Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Rbbp8 ortho G G G G G G G G G G G G G G G G G G G G G Setd2 Siah2 ortho Snca Siah2 ortho G G G G G G G G G Ddt Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Dcc Siah2 ortho G G Siah2 Scap ortho G G G G G G G G G G G G G G G G G G G G G Oprm1 Siah2 ortho Traf2 Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Pde9a Siah2 ortho G G G G G G G G G G G Siah2 Egln2 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Acpp ortho G Siah2 Pou2af1 ortho G G G G G G G G Ube2d2 Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Sncaip ortho G G G Siah2 Kat2b ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Pmepa1 ortho G G G G G G G G G G G G G G G G G G Siah2 Dlst ortho G G G G G G G G G G G G G G G G G G G G G Oprk1 Siah2 ortho G Siah2 Ppp1r12a ortho Siah2 Usp19 ortho G G G G G G G G G G G G G G G G G G G G G Ube2d3 Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Ube2l6 ortho G G G G G G G G Siah2 Steap2 ortho Siah2 Hipk2 ortho G G G G G G G G G G G G G G G G G G G G Siah2 Tmprss2 ortho G G G G G G G G G G G G G G Siah2 Dyrk2 ortho Siah2 Fxyd3 ortho G G G G G G G G G G G G Stat3 Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Nfe2l2 ortho G G G G G G G G G G G G G G G G G G G G G Tpx2 Siah2 ortho G G G G G G G G G G G G G Ube2d1 Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Psmd4 Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Usp13 ortho G G G Aff1 Siah2 ortho G G G G G G G G G G G G G G G G G G G G Siah2 Kat5 ortho Oprd1 Siah2 ortho Siah2 Xaf1 ortho Vav1 Siah2 ortho G G G G G Siah2 Peg3 ortho G G G G G G G G G G G G G G G G G G Tnk2 Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Siah2 Mme ortho G G G G G G G G G G Ar Siah2 ortho G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q06986 Q91UZ4 - 15210114 - X 2 Q06986 affinity chromatography technology 21389087 physical association X 2 Q06986 Q9QXV9 affinity chromatography technology 16888801 physical association X 2 Q06986 Q9WTP2 affinity chromatography technology 16888801 physical association X 2 Q06986 P37242 affinity chromatography technology 21389087 physical association X 2 P0CG48 Q06986 affinity chromatography technology 22055192 physical association X 2 Q9QXV8 Q06986 affinity chromatography technology 16888801 physical association X 2 Q06986 P37238-2 affinity chromatography technology 22294748 physical association X 2 Q06986 affinity chromatography technology 22294748 physical association X 2 Q06986 affinity chromatography technology 22055192 physical association X 2 Q06986 affinity chromatography technology 22055192 physical association X 2 Q06986 affinity chromatography technology 21389087 physical association X 2 Q06986 anti tag coimmunoprecipitation 23518348 association C 3 Q06986 cosedimentation through density gradient 18323779 colocalization C 4 Q06986 anti tag coimmunoprecipitation 18323779 association C 3 Q06986 anti tag coimmunoprecipitation 23518348 association C 3 P10275 Q06986 anti tag coimmunoprecipitation 23518348 physical association X 2 P10275 Q06986 anti tag coimmunoprecipitation 23518348 physical association X 2 P10275 Q06986 pull down 23518348 physical association X 2 P10275 Q06986 anti tag coimmunoprecipitation 23518348 physical association X 2 O08715 Q06986 two hybrid 18323779 physical association X 2 O08715 Q06986 fluorescence microscopy 18323779 colocalization X 2 O08715 Q06986 pull down 18323779 direct interaction X 2 O08715 Q06986 anti tag coimmunoprecipitation 18323779 physical association X 2 Q69ZI1 Q06986 two hybrid 16230351 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Akap1 Siah2 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18323779 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint) MINT_65048|UniProt_169577|MINT_65051|UniProt_169576|UniProt_169578|MINT_65042|MINT_65046|UniProt_169581|MINT_65049|UniProt_96134|UniProt_169579|MINT_35992 prey|prey|neutral component|bait|prey|bait|prey|neutral component|prey|prey|prey|prey bait|bait|neutral component|prey|bait|prey|bait|neutral component|bait|bait|bait|bait Siah2 Sh3rf1 MI:0007(anti tag coimmunoprecipitation) 16230351 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_164222 prey bait Pparg Siah2 MI:0004(affinity chromatography technology) 22294748 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321714 prey bait Thra Siah2 MI:0004(affinity chromatography technology) 21389087 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319995 bait prey Siah2 Ncor1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21389087,22294748 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_319993|BIOGRID_321715 prey|bait bait|prey Siah2 Spry4 MI:0018(two hybrid) 16888801 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316107 prey bait Siah2 Ngfr MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22055192 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_319622|BIOGRID_319623 bait|prey prey|bait Thrb Siah2 MI:0004(affinity chromatography technology) 21389087 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319994 bait prey Siah2 Spry2 MI:0018(two hybrid) 16888801 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316105 prey bait Siah2 Spry1 MI:0018(two hybrid) 16888801 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316106 prey bait

PPI - HINT Gene A Gene B PMID Method Quality AKAP1 SIAH2 18323779,18323779,18323779,18323779,18323779 0007,0416,0029,0096,0018 LC SIAH2 SH3RF1 16230351 0018 LC SIAH2 EGLN3 15210114,15210114,15210114 0004,0019,0045 LC AKAP1 SIAH2 18323779,18323779,18323779,18323779,18323779 0007,0416,0029,0096,0018 LC PPARG SIAH2 22294748 0004 LC THRB SIAH2 21389087 0004 LC THRA SIAH2 21389087 0004 LC SIAH2 NCOR1 22294748,21389087 0004,0004 LC SIAH2 PLCE1 17998205 0007 LC SIAH2 EGLN3 15210114,15210114,15210114 0004,0019,0045 LC SIAH2 SPRY2 16888801 0004 LC SIAH2 SPRY1 16888801 0004 LC SIAH2 SPRY4 16888801 0004 LC SIAH2 NGFR 22055192 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9WTP2 Q06986 SPRY4 SIAH2 0.21 16888801 Q06986 P10275 SIAH2 AR 0.61 23518348 Q92667 Q06986 AKAP1 SIAH2 0.309 18323779 Q06986 O08715 SIAH2 AKAP1 0.772 18323779 Q06986 P37242 SIAH2 THRB 0.21 21389087 Q9QXV9 Q06986 SPRY1 SIAH2 0.21 16888801 Q9QXV8 Q06986 SPRY2 SIAH2 0.21 16888801 Q06986 P63058 SIAH2 THRA 0.21 21389087 Q06986 P21796 SIAH2 VDAC1 0.126 18323779 Q06986 P37238 SIAH2 PPARG 0.21 22294748 Q69ZI1 Q06986 SH3RF1 SIAH2 0.309 16230351