PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Stat3 Cyld 23825949 biogrid exp Jun Cyld 21478324 biogrid exp Lck Cyld 16501569 innatedb,biogrid exp Casp8 Cyld 22037414 biogrid exp Fos Cyld 21478324 biogrid exp Ikbkg Cyld 22037414,23825957 biogrid exp, ortho Cyld Rnf31 24461064 biogrid exp, ortho Ripk1 Cyld 17981138 biogrid exp, ortho Sqstm1 Cyld 21878516,19201866,18174161,18382763 innatedb,biogrid exp, ortho Cyld Hdac6 19893491 mint,intact exp, ortho Traf6 Cyld 23782702,18174161,18382763 innatedb,biogrid exp, ortho Ntrk1 Cyld 18174161 innatedb exp, ortho Cyld Bcl3 16713561,19893491 biogrid,mint,intact exp, ortho Cyld Itch 23782702,22057290 biogrid,intact exp, ortho Tuba1a Cyld 19893491 mint,intact exp, ortho Clip3 Cyld ortho Dvl1 Cyld ortho Cyld Cd209e ortho Cyld Mgea5 ortho Cyld Trpa1 ortho Protein Cep192 Cyld ortho Plk1 Cyld ortho Cyld Cyld ortho Cyld Eif2b5 ortho Myo6 Cyld ortho Traf3 Cyld ortho Cyld Cntrob ortho Ppip5k1 Cyld ortho Cyld Traip ortho Cyld Protein Spata2, Spermatogenesis associated 2 ortho Lats2 Cyld ortho Cyld Arhgef12 ortho Pms2 Cyld ortho Ninl Cyld ortho Xpo1 Cyld ortho Cyld Spata2l ortho Cyld Cep128 ortho Cyld Mavs ortho Cep135 Cyld ortho Usp13 Cyld ortho Camk2d Cyld ortho Ubc Cyld ortho Ddx58 Cyld ortho Ppp2r4 Cyld ortho Cyld Mib2 ortho Cyld Traf7 ortho Anxa1 Cyld ortho Cyld Ube2s ortho Odf2 Cyld ortho Cyld Tbk1 ortho Traf2 Cyld ortho Cyld Ywhab ortho Cyld Med4 ortho Cyld Ikbke ortho Cyld Optn ortho Fgl2 Cyld ortho Egfr Cyld ortho Cyld Postmeiotic segregation increased 1 (S. cerevisiae), Protein Pms1 ortho Protein Cep350 Cyld ortho Dvl3 Cyld ortho Cyld Sphk1 ortho Aurkb Cyld ortho Mapre1 Cyld ortho Akt1 Cyld ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9Z2F6 Q80TQ2 two hybrid 16713561 physical association X 2 Q9Z2F6 Q80TQ2 two hybrid 16713561 physical association X 2 Q9Z2F6 Q80TQ2 anti bait coimmunoprecipitation 16713561 physical association X 2 Q9Z2F6 Q80TQ2 fluorescence microscopy 16713561 colocalization X 2 Q9Z2F6 Q80TQ2 anti bait coimmunoprecipitation 19893491 physical association X 2 Q80TQ2 anti bait coimmunoprecipitation 19893491 association C 3 P68369 Q80TQ2 anti bait coimmunoprecipitation 19893491 physical association X 2 P68369 Q80TQ2 fluorescence technology 19893491 colocalization X 2 P68369 Q80TQ2 fluorescence technology 19893491 colocalization X 2 P68369 Q80TQ2 anti bait coimmunoprecipitation 19893491 physical association X 2 Q80TQ2 Q9Z2V5 fluorescence technology 19893491 colocalization X 2 Q80TQ2 Q9Z2V5 fluorescence technology 19893491 colocalization X 2 Q80TQ2 Q9Z2V5 anti bait coimmunoprecipitation 19893491 physical association X 2 Q80TQ2 Q8C863 anti bait coimmunoprecipitation 22057290 physical association X 2 Q80TQ2 Q8C863 anti bait coimmunoprecipitation 22057290 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ikbkg Cyld MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22037414,23825957 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_331172|BIOGRID_331170|BIOGRID_322418 bait|prey|prey prey|bait|bait Stat3 Cyld MI:0004(affinity chromatography technology) 23825949 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_331176 bait prey Jun Cyld MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21478324 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_319642|BIOGRID_319641 prey|bait bait|prey Casp8 Cyld MI:0004(affinity chromatography technology) 22037414 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_322417 bait prey Traf6 Cyld MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18174161,18382763,23782702 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_312339|BIOGRID_312296|BIOGRID_331160 bait|bait|bait prey|prey|prey Fos Cyld MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21478324 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_319638|BIOGRID_319640 bait|prey prey|bait Tuba1a Cyld MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 19893491 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association) (intact)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint) UniProt_171757|MINT_76074|UniProt_171758|UniProt_171766|UniProt_171763|UniProt_171762|MINT_76089|MINT_76076|MINT_76087|MINT_76077 bait|bait|prey|neutral component|neutral component|bait|bait|neutral component|neutral component|prey prey|prey|bait|neutral component|neutral component|prey|prey|neutral component|neutral component|bait Cyld Rnf31 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24461064 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_332965|BIOGRID_332971|BIOGRID_332968|BIOGRID_332967 prey|bait|prey|prey bait|prey|bait|bait Ubc Cyld MI:0004(affinity chromatography technology) 18174161 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_312338 prey bait Lck Cyld MI:0004(affinity chromatography technology) 16501569 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315957 bait prey Cyld Bcl3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation) 16713561,19893491 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(intact)|MI:0471(mint)|(intact)|(intact) UniProt_166186|UniProt_166184|BIOGRID_319519|UniProt_166185|MINT_76079|UniProt_166183|UniProt_171759 neutral component|prey|prey|prey|prey|bait|prey neutral component|bait|bait|bait|bait|prey|bait Cyld Hdac6 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 19893491 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization) MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|MI:0471(mint) MINT_76080|MINT_76081|UniProt_171765|UniProt_171764|UniProt_171760|MINT_76085 bait|neutral component|neutral component|neutral component|bait|neutral component prey|neutral component|neutral component|neutral component|prey|neutral component Ripk1 Cyld MI:0004(affinity chromatography technology) 17981138 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_312351 prey bait Cyld Itch MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 22057290,23782702 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(intact)|(biogrid) BIOGRID_318784|BIOGRID_318783|UniProt_173875|UniProt_173874|BIOGRID_331161 bait|prey|bait|prey|bait prey|bait|prey|bait|prey Sqstm1 Cyld MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18174161,18382763,21878516 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_312297|BIOGRID_316143|BIOGRID_312340 prey|bait|prey bait|prey|bait

PPI - HINT Gene A Gene B PMID Method Quality CASP8 CYLD 22037414 0415 LC TUBA1A CYLD 19893491,19893491 0006,0051 LC CYLD BCL3 16713561,16713561,16713561,16713561 0416,0006,0004,0018 LC CYLD HDAC6 19893491,19893491 0006,0051 LC IKBKG CYLD 23825957,22037414 0004,0004 LC FOS CYLD 21478324 0004 LC JUN CYLD 21478324 0004 LC LCK CYLD 16501569 0004 LC UBC CYLD 26811477,18174161 0004,0004 LC STAT3 CYLD 23825949 0004 LC RIPK2 CYLD 26834734 0004 LC TUBA1A CYLD 19893491,19893491 0006,0051 LC TRAF6 CYLD 18382763,23782702,18382763,18174161,18174161 0007,0004,0004,0004,0007 LC NTRK1 CYLD 18174161 0007 LC RIPK1 CYLD 17981138 0004 LC SQSTM1 CYLD 21878516,19201866,18174161,18174161,18382763,18382763 0004,0007,0004,0007,0004,0007 LC CYLD ITCH 22057290,23782702,22057290 0006,0004,0004 LC CYLD RNF31 24461064,24461064 0096,0004 LC CYLD BCL3 16713561,16713561,19893491,16713561,16713561 0416,0006,0006,0004,0018 LC CYLD HDAC6 19893491,19893491 0006,0051 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q80TQ2 P58801 CYLD RIPK2 0.376 26834734 Q9Z2V5 Q80TQ2 HDAC6 CYLD 0.396 19893491 Q80TQ2 Q64337 CYLD SQSTM1 0.507 18174161,18382763,21878516 Q80TQ2 P0CG50 CYLD UBC 0.21 26811477 Q80TQ2 P01101 CYLD FOS 0.376 21478324 Q80TQ2 P05627 CYLD JUN 0.376 21478324 Q80TQ2 P0CG48 CYLD UBC 0.309 18174161 Q80TQ2 P68369 CYLD TUBA1A 0.523 19893491 Q80TQ2 Q60855 CYLD RIPK1 0.21 17981138 Q80TQ2 O88522 CYLD IKBKG 0.507 23825957,22037414 Q80TQ2 O89110 CYLD CASP8 0.309 22037414 Q8C863 Q80TQ2 ITCH CYLD 0.507 22057290,23782702 Q80TQ2 P06240 CYLD LCK 0.21 16501569 Q924T7 Q80TQ2 RNF31 CYLD 0.454 24461064 Q9Z2F6 Q80TQ2 BCL3 CYLD 0.794 16713561,19893491 Q80TQ2 P70196 CYLD TRAF6 0.507 18174161,18382763,23782702 Q80TQ2 P42227 CYLD STAT3 0.21 23825949