PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Topors Phc2 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdc1 Topors 22912899 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G Ifi205b Topors 16458891 mint,intact exp G G G G G Tp53 Topors 15735665 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sumo2 Topors ortho Topors Ube2l6 ortho G G G G G G G G G Topors Nono ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Casp8 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G Ube2d1 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dhx15 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rac1 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Topors Sfpq ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sin3a Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G S100a9 Topors ortho G G G G G G G G G G G G G G G G Topors Ube2j1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Topors Nifk ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sumo1 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Topors Ikbke ortho G G G G G G G G G G G G G Ube2i Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G H2afx Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn7 Topors ortho Ube2d2 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Satb1 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G Rangap1 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pml Topors ortho G G G G G G G G G G G G G G G G G G G G G Setx Topors ortho Nkx3-1 Topors ortho G MCG3697, isoform CRA_c, Protein Upf3a, UPF3 regulator of nonsense transcripts homolog A (Yeast) Topors ortho Safb2 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mtdh Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbbp7 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Topors Snip1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Topors Hnrnpm ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spin1 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2n Topors ortho Top1 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Topors Ddb2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Topors Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Parp1 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2b Topors ortho G Topors Habp4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Topors Serbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Topors Sf3b1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2e1 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Topors Sept6 ortho G G G G G G G G G G G G G G G G G Ubc Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smarcc2 Topors ortho Topors Ube2w ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Topors Gtf2i ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eef1a1 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbbp4 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trim28 Topors ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Plk1 Topors ortho G G G G G G G G G G G G G G Topors Hnrnpl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q80Z37 - 15735665 - X 2 Q80Z37 Q9QWH1 - 15735665 - X 2 Q80Z37 Q549C9 affinity chromatography technology 15735665 physical association X 2 Q80Z37 P18828 affinity chromatography technology 22912899 physical association X 2 Q80Z37 P18828 two hybrid 22912899 direct interaction X 2 Q08619 Q80Z37 two hybrid pooling approach 16458891 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality TP53 TOPORS 15735665,15735665 0019,0004 LC SDC1 TOPORS 22912899,22912899 0004,0018 LC IFI205B TOPORS 16458891 0398 LC TOPORS PHC2 15735665 0018 LC TP53 TOPORS 15735665,15735665 0019,0004 LC SDC1 TOPORS 22912899,22912899 0004,0018 LC PSMC1 TOPORS 26872363 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q80Z37 P62192 TOPORS PSMC1 0.21 26872363 Q80Z37 Q08619 TOPORS IFI205B 0.21 16458891 Q80Z37 P02340 TOPORS TP53 0.21 15735665 Q80Z37 P18828 TOPORS SDC1 0.454 22912899