PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Aff2 Siah1a 15459319 biogrid exp Gapdh Siah1a 16505364 biogrid,i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Dab1 12646221 intact exp, ortho G G G G G G G G Oprm1 Siah1a 23840749 biogrid exp, ortho Siah1a Aff4 15459319 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Sh3rf1 16230351 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G Siah1a Cacybp 15996101 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Siah1a 11742346 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snca Siah1a ortho G G G G G G G G G G G G G G G G Siah1a Tbl1x ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Oprk1 Siah1a ortho G G G G G G Siah1a Tuba1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mapk12 Siah1a ortho G G G G G G G G G G G G G G G G G G G Siah1a Sft2d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Wdyhv1 ortho Siah1a Dcc ortho G G G G Stat3 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Inha ortho G G G G G G G G G G G G G G G G G G G Vav1 Siah1a ortho G G G G G Siah1a Ube2l6 ortho G G G G G G G G G Siah1a Psmc6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Hif1an ortho Siah1a Kiaa0319l ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Ell2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Kcnj10 ortho G G G G G G G G G G G G Siah1a Pclo ortho G G G G G G G G G G Ube2e3 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Mapk8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Jsrp1 ortho Siah1a Usp19 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Capg Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Flt3 ortho G G G G G G G Kifc3 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dld Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Txn Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Sncaip ortho G G G G G G G Zmat3 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Runx1 ortho G G G G G G G G G G G G G G G G Siah1a Kif1b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Trim27 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Ezh2 ortho G G G G G G G G G G G G G G G G G G G G G G G Siah1a Khdrbs3 ortho G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Armc9 ortho Arpc4 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Rad51ap1 ortho G G G G G G G G G Protein Raph1 Siah1a ortho Siah1a Pard3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Pml ortho G G G G G G G G G G G G G G G G G G G G G Siah1a Peg10 ortho G Siah1a Mapre3 ortho G G G G G G G G G G G G G G G G G G G G G G Terf2 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Mapkbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Ptch1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Aff1 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Surf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Peg3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Npm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Tmem43 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Trib3 ortho G G G G G G G G G G G Siah1a Siah2 ortho G G G G G G G G G G G G G G G G G G G G G Siah1a Rbbp8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Dvl2 ortho G G G G G G G G G G G G Siah1a Rlim ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fli1 Siah1a ortho G G G G G G G G G G G G G G G G G Cops5 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Aasdhppt ortho Myd88 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Rab33a ortho G G G G G G G Siah1a Kif22 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Numbl Siah1a ortho G G G G G G G G G G G G G G G G G G G G G Siah1a Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Lactb2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Scrib ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4a, Hist4h4 ortho G G G G G G G G G G G G G G Pfkm Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Rps19bp1 ortho Siah1a Grm5 ortho Sept4 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pvrl2 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Lipt1 ortho G G G G G G G G G G G G G G G G Cul4b Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Ctnnb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Rnf2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Ddx41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Uncharacterized protein C14orf105 homolog ortho G G G G G G Siah1a Gopc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Grm1 ortho G G G G G G G G G G Ube2d3 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Gdpd5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a BC045600 ortho Siah1a Phc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Rapsn Siah1a ortho G G Siah1a Nol10 ortho Hipk1 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Puf60 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Uxt ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Trim8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Apc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Hipk2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Tuba8 ortho G G G G G G G G G G G G G G Siah1a Zbp1 ortho G G G G G G G G G G G G G G Siah1a Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Ube2v2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Nol6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Skt Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Slc9a3r2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Atn1 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Atxn7 ortho G G G G G G G G G G G G Rpl27a Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Zfyve21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Znf512b ortho Siah1a Rad54l2 ortho G G G G G G G G G G G G G G Ube2k Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tuba1b Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Tfdp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Oprd1 Siah1a ortho Pias1 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Ube2d2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mab21l1 Siah1a ortho G G G G Rara Siah1a ortho G G Htt Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Cdk5r1 ortho G G G G G G G G G G G G G G G Siah1a Cops7b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Numb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Upp2 ortho G G G Ube2n Siah1a ortho Siah1a Ube2d2b ortho G Siah1a Spatc1l ortho Siah1a Fzd9 ortho G G G Pkd1 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Dnajc15 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Znf148 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Plce1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Aqp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Bsn Siah1a ortho G G G G G G Siah1a Spata4 ortho G G Siah1a Hipk3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eef1d Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Qrich1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Pou2af1 ortho G G G G G G G G Klf10 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Trim23 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Pias2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Syt7 ortho G G Siah1a Ptpmt1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Prpf31 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Sarm1 ortho Siah1a Psmc5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Ube2e2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Tp53bp2 ortho Siah1a Ttyh3 ortho Siah1a Herpud1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Cdc23 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Otub2 ortho G G G G G G G G G G G G Siah1a Xiap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Tuba4a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Pygb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Bag1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Syp ortho G G G G G G G G G G G G Siah1a Ube2i ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpl9 Siah1a ortho Siah1a Dnali1 ortho Siah1a Mob3c ortho Siah1a Katnal1 ortho Siah1a Kif5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d1 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Phc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Nelfa ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Mtif3 ortho Siah1a Trim7 ortho G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P61092 D2KHZ9 - 15951807 - X 2 P61092 P61092 - 11742346,8404535 - X 2 P61092 P61092 - 11742346,8404535 - X 2 P61092 Q9CXW3 pull down 15996101 direct interaction X 2 P61092 D2KHZ9 affinity chromatography technology 16505364 physical association X 2 P61092 D2KHZ9 pull down 16505364 direct interaction X 2 P61092 two hybrid 20368287 direct interaction X 2 P61092 P42866-8 affinity chromatography technology 23840749 physical association X 2 P61092 P61092 x-ray crystallography 11742346 association X 2 P61092 O55112 unspecified method 15459319 direct interaction X 2 P61092 O55112 affinity chromatography technology 15459319 physical association X 2 P61092 Q27934 unspecified method 12626763 direct interaction X 2 P61092 Q27934 pull down 12626763 direct interaction X 2 Q9ESC8 P61092 unspecified method 15459319 direct interaction X 2 Q9ESC8 P61092 affinity chromatography technology 15459319 physical association X 2 P61092 Q27934 pull down 16615911 direct interaction X 2 P61092 Q27934 x-ray crystallography 16615911 direct interaction X 2 P61092 Q69ZI1 two hybrid 16230351 physical association X 2 Q99490 P61092 two hybrid 20368287 physical association X 2 P61092 P97318 two hybrid 12646221 physical association X 2 P61092 P97318 coimmunoprecipitation 12646221 physical association X 2 P61092 P97318 pull down 12646221 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Aff2 Siah1a MI:0686(unspecified method)|MI:0686(unspecified method) 15459319 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_321742|BIOGRID_321744 prey|prey bait|bait Siah1a Sh3rf1 MI:0007(anti tag coimmunoprecipitation) 16230351 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_164220 prey bait Siah1a Aff4 MI:0686(unspecified method)|MI:0686(unspecified method) 15459319 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_321743|BIOGRID_321741 bait|bait prey|prey Siah1a Cacybp MI:0096(pull down) 15996101 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_321776 prey bait Siah1a Dab1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 12646221 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_162082|UniProt_162081|UniProt_162080 bait|prey|prey prey|bait|bait Gapdh Siah1a MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16505364 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_321916|BIOGRID_321917 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality GAPDH SIAH1A 15951807 0019 LC SIAH1A SIAH1A 11742346,8404535,16615911 0114,0114,0114 LC SIAH1A DAB1 12646221,12646221,12646221 0018,0019,0096 LC SIAH1A SH3RF1 16230351 0018 LC AFF2 SIAH1A 15459319 0004 LC GAPDH SIAH1A 16505364,16505364 0096,0004 LC OPRM1 SIAH1A 23840749 0004 LC SIAH1A DAB1 12646221,12646221,12646221 0018,0019,0096 LC SIAH1A CACYBP 15996101 0096 LC SIAH1A AFF4 15459319 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P61092 P61092 SIAH1A SIAH1A 0.332 11742346 P97318 P61092 DAB1 SIAH1A 0.569 12646221 Q99490 P61092 AGAP2 SIAH1A 0.454 20368287 Q69ZI1 P61092 SH3RF1 SIAH1A 0.309 16230351 P61092 O55112 SIAH1A AFF2 0.454 15459319 Q9ESC8 P61092 AFF4 SIAH1A 0.454 15459319 Q9CXW3 P61092 CACYBP SIAH1A 0.309 15996101 P61092 P42866 SIAH1A OPRM1 0.126 23840749 Q27934 P61092 PHYL SIAH1A 0.772 12626763,16615911