PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Socs5 Jak1 23990909 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G Socs5 Cul5 19385048 biogrid exp Socs5 Jak2 23990909 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Socs5 Egfr 15695332 biogrid,mint,intact exp, ortho G G G G G G G G G G G G G G G Socs5 Il4r 12242343 innatedb exp, ortho G G G G G G G G G G G G G G G G Socs5 Tyk2 23990909 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Socs5 Tnfrsf1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Socs1 Socs5 ortho Socs5 Stat4 ortho G G G G Socs5 Ppp5c ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Socs5 Alk ortho G G G G G Socs5 Il2rb ortho G G G G G G Socs5 Dcun1d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Socs5 Socs5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Socs5 Kit ortho G G G G G G G G G G G G G G G G G G G G G G Socs5 Cd80 ortho G G G G G G Socs5 Tmbim1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Socs5 Ccr1 ortho G G G G G G G G G Socs5 Met ortho G G G G G G G G G G G G G G G G G G G G G G Socs5 Ifnar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Socs5 Stat3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Socs5 App ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Socs5 Tnfrsf1b ortho G G G G G G G G G G G G G G G G G G G Socs5 Igfbp3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Nmi Socs5 ortho G G G G G G G G G G G G G G G G G G G G G G G Socs5 Rela ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Socs5 Stat2 ortho G G G G G G G G G G G G G G G G G G G G G G Ifnar2 Socs5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Socs5 Stat5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Socs5 Casp3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Socs5 Stat5a ortho G G G G G G G G G G G G G G G G G G G G G Socs5 Cebpa ortho G G G G G G G G G G G G G G G G G G G G G G Socs5 Ubc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Socs5 Tceb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O54928 pull down 23990909 direct interaction X 2 O54928 pull down 23990909 direct interaction X 2 O54928 P29353-5 affinity chromatography technology 23990909 physical association X 2 O54928 Q15369-2 biochemical 19385048 association X 2 O54928 Q15369-2 x-ray crystallography 19385048 association X 2 O54928 Q15369-2 pull down 19385048 direct interaction X 2 O54928 Q9D5V5 pull down 19385048 direct interaction X 2 O54928 Q01279 affinity chromatography technology 15695332 physical association X 2 O54928 G5E852 pull down 23990909 direct interaction X 2 O54928 pull down 23990909 direct interaction X 2 O54928 A0A024R7M7 pull down 23990909 direct interaction X 2 O54928 Q15370-2 biochemical 19385048 association X 2 O54928 Q15370-2 x-ray crystallography 19385048 association X 2 O54928 Q15370-2 pull down 19385048 direct interaction X 2 O54928 Q15370 anti bait coimmunoprecipitation 15695332 physical association X 2 O54928 A0A024R7Y5 anti bait coimmunoprecipitation 15695332 physical association X 2 O54928 Q01279 anti bait coimmunoprecipitation 15695332 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Socs5 Cul5 MI:0401(biochemical) 19385048 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_319472 prey bait Socs5 Egfr MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 15695332 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|(biogrid) MINT_60358|UniProt_165603|BIOGRID_324155 prey|prey|prey bait|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality SOCS5 IL4R 12242343 0059 LC SOCS5 JAK1 23990909 0096 LC SOCS5 EGFR 15695332,15695332 0004,0006 LC SOCS5 JAK2 23990909 0096 LC SOCS5 CUL5 19385048 0096 LC SOCS5 TYK2 23990909 0096 LC