PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Cdk5r1 Sik2 24561619 dip exp Sik2 Sik2 24561619 dip exp, ortho Ppp2r1b Sik2 ortho Ywhae Sik2 ortho Akt2 Sik2 ortho Tuba4a Sik2 ortho Cep250 Sik2 ortho Ppp2r2c Sik2 ortho Irs1 Sik2 ortho Sik2 Slc25a13 ortho Xpo1 Sik2 ortho Sik2 Hdac5 ortho Ywhaz Sik2 ortho Ppp2r2a Sik2 ortho Cetn3 Sik2 ortho Ppp2ca Sik2 ortho Csnk1a1 Sik2 ortho Crtc2 Sik2 ortho Fbxw11 Sik2 ortho Hspb1 Sik2 ortho Ppp2r1a Sik2 ortho App Sik2 ortho Prkaa1 Sik2 ortho Ppp2r2b Sik2 ortho Sik2 Shroom3 ortho Sik2 Bag2 ortho Trim28 Sik2 ortho Hspa2 Sik2 ortho Hspa4 Sik2 ortho Emd Sik2 ortho Gabarapl2 Sik2 ortho Vcp Sik2 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8CFH6 Q8CFH6 protein kinase assay 24561619 direct interaction Y 1 Q8CFH6 P61809 anti bait coimmunoprecipitation 24561619 direct interaction X 2 Q8CFH6 P61809 anti bait coimmunoprecipitation 24561619 direct interaction X 2 Q8CFH6 P61809 protein kinase assay 24561619 direct interaction X 2

PPI - HINT Gene A Gene B PMID Method Quality CDK5R1 SIK2 24561619,24561619 0006,0424 LC SIK2 SIK2 24561619 0424 LC CDK5R1 SIK2 24561619,24561619 0006,0424 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8CFH6 P35568 SIK2 IRS1 0.309 12624099