PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Cdc42 Prkci 10934474 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Mtss1 23446420 dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab4a Prkci i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Pard3 9763423 innatedb,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Pard6a 12813044 innatedb,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Prkci Pard6b 12725730 innatedb exp, ortho G G G G G G G G G G Prkci Frs2 10383403 biogrid,i2d exp, ortho Prkci Llgl1 12725730,12629547 innatedb,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Prkci 22579248 dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Llgl2 Prkci 12725730 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G Ywhae Prkci 16615898 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Map2k5 12813044 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Npm1 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Tmem17 ortho Smarcd1 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G Prkci Eif4enif1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppm1a Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Frs3 ortho G G G G G G G G G G G G G Hpd Prkci ortho G G G G G G G G G G Gli1 Prkci ortho G G G Vhl Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Slx4 ortho Fabp4 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Arhgap17 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Rhoj ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Gabarap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Strip1 ortho Gbas Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Tmem208 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppm1b Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Rapgef2 ortho Prkci Amot ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Mbp Prkci ortho G G G G G G G G G G G G G G G G G G G G Ripk1 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G Kif23 Prkci ortho G G G G G G G G G G G G G G Nipsnap1 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G Apc Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Mastl ortho G G Src Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Chn2 ortho G G G G G G G G G G G G G G G G G G Prkci Nfkbia ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Pnma1 ortho Casp8 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G Rab2a Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ssb Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spata18 Prkci ortho Prkci Rhoq ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkcz Prkci ortho G G G G G G G G G G G G G G G G G G G G G G Prkci Cep135 ortho Elavl1 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Smg1 ortho Ywhah Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Pawr ortho G G G G G G G G G G G G G G G G G G G G G G Tsc22d1 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Mark4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc42bpa Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk7 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sell Prkci ortho G G G G G G G G Hsp90aa1 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90ab1 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sox2 Prkci ortho G G G G G G G G G G G Rac1 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Pdpk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkcq Prkci ortho G G G G G G G G G G G G G G G G Map2k1 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Usp20 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhaz Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Gabarapl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hras Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gabarapl2 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gria1 Prkci ortho G G G G G G G G Ttr Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G Prkci Pard6g ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kpna6 Prkci ortho G G G G G G G G G G G G G Prkci Mpi ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkb Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trappc13 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adam19 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G Myo10 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Maged2 protein, Protein Maged2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Anxa1 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Crx Prkci ortho G Chuk Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dusp1 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc37 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Znf609 ortho Il1rap Prkci ortho G G Prkci Map1lc3b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkg Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Adap1 Prkci ortho Prkci Irak1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Usp21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Xpo1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bad Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Gab1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Map1lc3a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Rassf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Mark2 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Sfpq ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tjp1 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G App Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pex5 Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q62074 Q13501 pull down 16861740 direct interaction X 2 Q62074 Q8C180 affinity chromatography technology 10383403 physical association X 2 Q62074 anti tag coimmunoprecipitation 10934474 association C 4 Q62074 coimmunoprecipitation 11532031 association C 4 Q62074 coimmunoprecipitation 11257119 association C 4 Q62074 pull down 14653998 association C 7 Q62074 coimmunoprecipitation 15723051 association C 3 Q62074 anti bait coimmunoprecipitation 12629547 association C 3 Q62074 anti bait coimmunoprecipitation 14960283 association C 3 Q62074 coimmunoprecipitation 11532031 association C 6 Q62074 anti bait coimmunoprecipitation 16638806 association C 3 Q62074 coimmunoprecipitation 15723051 association C 3 Q62074 pull down 14653998 association C 4 Q62074 anti bait coimmunoprecipitation 15048131 association C 3 Q62074 anti bait coimmunoprecipitation 23446420 - C 4 Q62074 Q8TEW0 pull down 22579248 direct interaction X 2 Q62074 Q8TEW0 protein kinase assay 22579248 direct interaction X 2 Q62074 Q8TEW0 x-ray crystallography 22579248 direct interaction X 2 Q62074 Q8TEW0 pull down 22579248 direct interaction X 2 Q62074 Q8TEW0 protein kinase assay 22579248 direct interaction X 2 Q62074 Q8TEW0 pull down 22579248 direct interaction X 2 Q62074 Q8TEW0 pull down 22579248 direct interaction X 2 Q62074 Q62074 pull down 22579248 physical association Y 1 Q62074 Q8R1S4 anti bait coimmunoprecipitation 23446420 physical association X 2 Q62074 Q8R1S4 anti bait coimmunoprecipitation 23446420 physical association X 2 Q62074 Q8R1S4 anti bait coimmunoprecipitation 23446420 physical association X 2 Q62074 Q8R1S4 anti bait coimmunoprecipitation 23446420 physical association X 2 Q62074 cosedimentation 16615898 colocalization C 1216 Q62074 coimmunoprecipitation 10934474 association C 4 Q62074 P56371 coimmunoprecipitation 12832475 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Prkci Frs2 MI:0018(two hybrid) 10383403 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_312124 bait prey

PPI - HINT Gene A Gene B PMID Method Quality RAB4A PRKCI 12832475 0019 LC CDC42 PRKCI 10934474 0019 LC YWHAE PRKCI 16615898 0027 LC PRKCI LLGL1 12629547,12629547,12629547 0045,0019,0424 LC PRKCI FRS2 10383403,10383403,10383403 0018,0004,0019 LC PRKCI PARD3 10934475,10934475,15723052 0004,0019,0019 LC PRKCI PRKCI 22579248 0096 LC PRKCI FRS2 10383403,10383403,10383403 0018,0004,0019 LC PRKCI MTSS1 23446420 0006 LC PRKCI PARD3 10934475,10934475,9763423 0004,0019,0007 LC PRKCI PARD6A 10934475 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q62074 P60766 PRKCI CDC42 0.21 10934474 Q62074 J3QRV5 PRKCI LLGL2 {ECO:0000313|ENSEMBL:ENSP00000464397} 0.126 26496610 Q62074 P56381 PRKCI ATP5E 0.126 26496610 Q62074 Q5VTU8 PRKCI ATP5EP2 0.126 26496610 Q6P1M3 Q62074 LLGL2 PRKCI 0.126 26496610 Q8C180 Q62074 FRS2 PRKCI 0.21 10383403 Q62074 P62259 PRKCI YWHAE 0.081 16615898 Q62074 P79522 PRKCI PRR3 0.236 26496610 Q62074 P51648 PRKCI ALDH3A2 0.236 26496610 Q62074 P50570 PRKCI DNM2 0.236 26496610 Q62074 P35052 PRKCI GPC1 0.236 26496610 Q62074 O14925 PRKCI TIMM23 0.236 26496610 Q62074 P25391 PRKCI LAMA1 0.236 26496610 Q62074 O95243 PRKCI MBD4 0.236 26496610 Q62074 O75323 PRKCI GBAS 0.236 26496610 Q62074 P18887 PRKCI XRCC1 0.236 26496610 Q62074 P11216 PRKCI PYGB 0.236 26496610 Q62074 P17036 PRKCI ZNF3 0.236 26496610 Q9UJF2 Q62074 RASAL2 PRKCI 0.236 26496610 Q8TEW0 Q62074 PARD3 PRKCI 0.236 26496610 Q62074 Q14145 PRKCI KEAP1 0.236 26496610 Q7Z7K6 Q62074 CENPV PRKCI 0.236 26496610 Q62074 Q15334 PRKCI LLGL1 0.236 26496610 Q76FK4 Q62074 NOL8 PRKCI 0.236 26496610 Q9NX00 Q62074 TMEM160 PRKCI 0.236 26496610 Q9BYG5 Q62074 PARD6B PRKCI 0.236 26496610 Q96SY0 Q62074 VWA9 PRKCI 0.236 26496610 Q9BPW8 Q62074 NIPSNAP1 PRKCI 0.236 26496610 Q9NPB6 Q62074 PARD6A PRKCI 0.236 26496610 Q9H089 Q62074 LSG1 PRKCI 0.236 26496610 Q9HC07 Q62074 TMEM165 PRKCI 0.236 26496610 Q9Y3B7 Q62074 MRPL11 PRKCI 0.236 26496610 Q9Y676 Q62074 MRPS18B PRKCI 0.236 26496610 Q62074 Q13501 PRKCI SQSTM1 0.472 26496610,16861740