PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Atg5 Pgls 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map1lc3a Atg5 18946037 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Atg5 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab33b Atg5 18448665 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Casp8 Atg5 18946037,22362782 innatedb,biogrid,dip exp GP G G G G G G G G G G G G G G G G G G G G G G G Ripk1 Atg5 18946037 innatedb,biogrid,dip exp GP G G G G G G G G G G G G G G G G G G G G G G G G Atg10 Atg5 12482611 i2d,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Atg5 12665549 innatedb exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Atg12 12665549,12482611,20723759 innatedb,biogrid,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdfy3 Atg5 20417604 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fadd Atg5 18946037,22362782 innatedb,biogrid,dip exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Atg5 12665549,18448665 innatedb,biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rcc2 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdkn2a Atg5 ortho Pphln1 Atg5 ortho Atg5 Atg3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cav1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Stoml2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tecpr1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Psma1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hprt1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rhpn2 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G Becn1 Atg5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rrm1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Clpp Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbbp4 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkce Atg5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Actg1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Terf2 Atg5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wipi2 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mavs Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Psma3 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Cmpk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Got2 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Echs1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx58 Atg5 ortho P Pcdh18 Atg5 ortho GP G G G G G G G G G G G G G G G G G Mif Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Rb1cc1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vcp Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tab3 Atg5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc12 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Xpo1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Uchl1 ortho P G G G G G G G G G G G G G G G G G G Bcl2l1 Atg5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gdi2 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Srp14 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Meox2 Atg5 ortho G G G G G G G G G G Psma2 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tekt4 Atg5 ortho Snca Atg5 ortho P G G G G G G G G G G G G G G G G Ulk1 Atg5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fabp5 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Plod2 ortho G G G G G G G G G G G G G G G G G G G G G Atg5 Gabarap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp6v1e1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Ralb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab7a Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pa2g4 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ifih1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Dars Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpl3 Atg5 ortho P Htt Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Capza1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Tagln2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Sh3glb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psme3 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gabarapl2 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gxylt1 Atg5 ortho Edaradd Atg5 ortho G G G G G Cchcr1 Atg5 ortho Gstm5 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Rexo2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg13 Atg5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Elavl1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gabarapl1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Psma7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Cnn3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eef1b Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tsn Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp5j2 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nudc Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps16 Atg5 ortho P Snx3 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Capn2 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kctd12 Atg5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Exoc4 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lrrc59 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Aco2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G P4hb Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Fem1b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nap1l1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Atp5d ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspe1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sirt1 Atg5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Map1lc3b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pgrmc1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg5 Ndufa10 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps3 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r5e Atg5 ortho Mdh1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l2 Atg5 ortho Atg5 Atg101 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fgfr1 Atg5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Pum2 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tkt Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc42bpa Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Capn1 Atg5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Atg5 Cndp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q99J83 Q8R1P4 - 12482611 - X 2 Q60855 Q99J83 affinity chromatography technology 18946037 physical association X 2 Q61160 Q99J83 affinity chromatography technology 22362782 physical association X 2 Q61160 Q99J83 affinity chromatography technology 18946037 physical association X 2 Q61160 Q99J83 affinity chromatography technology 18946037 physical association X 2 Q99J83 Q91VR7 affinity chromatography technology 18946037 physical association X 2 Q9CQY1 Q99J83 pull down 12482611 direct interaction X 2 Q9CQY1 Q99J83 affinity chromatography technology 12665549 physical association X 2 Q99J83 O89110 affinity chromatography technology 22362782 physical association X 2 Q99J83 O35963 affinity chromatography technology 18448665 physical association X 2 Q99J83 Q8C0J2-4 affinity chromatography technology 12665549 physical association X 2 Q99J83 Q8C0J2-4 affinity chromatography technology 12665549 physical association X 2 Q99J83 Q8C0J2-4 affinity chromatography technology 12665549 physical association X 2 Q99J83 O89110 affinity chromatography technology 18946037 physical association X 2 Q99J83 Q8C0J2-4 imaging technique 12665549 colocalization X 2 Q99J83 affinity chromatography technology 12665549 association C 3 Q99J83 mass spectrometry studies of complexes 12665549 association C 3 Q99J83 two hybrid 12665549 association C 3 Q99J83 coimmunoprecipitation 12665549 association C 3 Q99J83 tandem affinity purification 18946037 - C 5 Q99J83 anti tag coimmunoprecipitation 18946037 - C 4 Q60855 Q99J83 anti tag coimmunoprecipitation 18946037 physical association X 2 Q61160 Q99J83 tandem affinity purification 18946037 physical association X 2 Q61160 Q99J83 anti tag coimmunoprecipitation 18946037 physical association X 2 Q99J83 O89110 anti tag coimmunoprecipitation 18946037 physical association X 2 Q99J83 A0A024RAG3 fluorescence microscopy 21241894 colocalization X 2 Q9CQY1 Q99J83 biochemical 12482611 physical association X 2 Q9CQY1 Q99J83 two hybrid 12482611 physical association X 2 Q9CQY1 Q99J83 anti tag coimmunoprecipitation 20723759 physical association X 2 Q99J83 anti bait coimmunoprecipitation 20417604 physical association C 4 Q99J83 Q8R1P4 two hybrid 12482611 physical association X 2 Q99J83 Q8R1P4 two hybrid 12482611 physical association X 2 Q99J83 Q6VNB8 anti bait coimmunoprecipitation 20417604 physical association X 2 Q99J83 Q96A65 anti tag coimmunoprecipitation 21241894 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Atg16l1 Atg5 MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0676(tandem affinity purification) 12665549,18946037 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0465(dip) BIOGRID_325847|BIOGRID_325851|BIOGRID_325848|BIOGRID_325850|DIP_641 prey|bait|prey|prey|- bait|prey|bait|bait|- Wdfy3 Atg5 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 20417604 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_107356|UniProt_170893 bait|bait prey|prey Rab33b Atg5 MI:0004(affinity chromatography technology) 18448665 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322938 bait prey Atg5 Atg12 MI:0018(two hybrid)|MI:0096(pull down)|MI:0428(imaging technique)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 12482611,12665549,20723759 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(intact)|(intact) UniProt_163495|BIOGRID_323800|BIOGRID_325849|UniProt_163503|UniProt_172806 prey|prey|bait|neutral component|prey bait|bait|prey|neutral component|bait Atg10 Atg5 MI:0018(two hybrid)|MI:0018(two hybrid) 12482611 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_163494|UniProt_163498 prey|bait bait|prey Ripk1 Atg5 MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification) 18946037 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|-|- MI:0465(dip)|MI:0465(dip)|MI:0465(dip) DIP_667|DIP_641|DIP_642 -|-|- -|-|- Casp8 Atg5 MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 18946037,22362782 taxid:10090(Mus musculus) taxid:10090(Mus musculus) -|-|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0465(dip)|(biogrid)|MI:0465(dip) DIP_641|DIP_642|BIOGRID_320614|DIP_668 -|-|prey|- -|-|bait|- Fadd Atg5 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification) 18946037,22362782 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|-|- MI:0465(dip)|(biogrid)|MI:0465(dip)|MI:0465(dip) DIP_665|BIOGRID_320615|DIP_641|DIP_642 -|prey|-|- -|bait|-|-

PPI - HINT Gene A Gene B PMID Method Quality YWHAE ATG5 16615898 0027 LC ATG16L1 ATG5 12665549,12665549,12665549,12665549,12665549 0004,0007,0428,0018,0663 LC ATG10 ATG5 12482611 0018 LC ATG5 PGLS 16615898 0027 LC ATG5 ATG12 12482611,12482611,12482611 0401,0096,0018 LC RAB33B ATG5 18448665 0004 LC CASP8 ATG5 18946037,18946037,22362782 0007,0004,0004 LC RIPK1 ATG5 18946037,18946037 0007,0004 LC FADD ATG5 18946037,18946037,22362782,18946037 0004,0007,0004,0676 LC WDFY3 ATG5 20417604 0006 LC ATG16L1 ATG5 12665549,12665549,12665549,12665549,12665549,18448665 0004,0007,0428,0018,0663,0007 LC MAP1LC3A ATG5 18946037 0004 LC ATG5 ATG5 12665549 0007 LC ATG5 ATG12 20723759,12665549,12482611,12665549,12482611,12482611 0007,0004,0401,0007,0096,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q99J83 P62259 ATG5 YWHAE 0.081 16615898 Q99J83 Q8R1P4 ATG5 ATG10 0.309 12482611 Q99J83 O89110 ATG5 CASP8 0.396 22362782,18946037 Q99J83 O35963 ATG5 RAB33B 0.21 18448665 Q99J83 P11234 ATG5 RALB 0.081 21241894 Q99J83 Q61160 ATG5 FADD 0.539 22362782,18946037 Q9CQY1 Q99J83 ATG12 ATG5 0.814 12482611,20723759,12665549 Q99J83 Q8C0J2 ATG5 ATG16L1 0.858 12665549 Q99J83 Q96A65 ATG5 EXOC4 0.126 21241894 Q99J83 Q91VR7 ATG5 MAP1LC3A 0.21 18946037 Q99J83 O94817 ATG5 ATG12 0.21 12665549 Q99J83 Q6VNB8 ATG5 WDFY3 0.21 20417604 Q99J83 Q60855 ATG5 RIPK1 0.236 18946037 Q99J83 Q99J83 ATG5 ATG5 0.236 12665549 Q9CQ60 Q99J83 PGLS ATG5 0.081 16615898 Q99J83 P42858 ATG5 HTT 0.21 20417604