PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Acta2 Lasp1 15465019 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Lasp1 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkaca Lasp1 15465019 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vasp Lasp1 15465019 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Pgls 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Invs Lasp1 21565611 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G Lasp1 Ywhab 16635246 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Zyx 15465019 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkg1 Lasp1 15465019 biogrid exp, ortho G G G G G G G Lasp1 Lpp 15465019 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hax1 Lasp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspb1 Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Pot1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Spry2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Trim27 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dnm1 Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G Lasp1 Vapb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Uncharacterized protein C11orf65 homolog ortho Fbf1 Lasp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Tjp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr3c1 Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Thap1 ortho Stat3 Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tcf4 Lasp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk7 Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rel Lasp1 ortho G G G G Lasp1 Plscr1 ortho G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Olfr63 ortho Lasp1 Zc2hc1a ortho Lasp1 Golga2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc8 Lasp1 ortho Protein Ahnak Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Crk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Sh2d2a ortho G G Lgals1 Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Eps8l1 ortho G G G G G G G G G Cxcr4 Lasp1 ortho G G G G G G G G G G G Atxn1 Lasp1 ortho Lasp1 Tinf2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cxcr2 Lasp1 ortho G G G G Actc1 Lasp1 ortho GP G G G G G G G G G G G G G G G Dnm2 Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Fhl3 ortho G Cxcr3 Lasp1 ortho G G G G G G G G G G G G Lasp1 Slc25a32 ortho P Tas2r41 Lasp1 ortho Mdfi Lasp1 ortho G G G Ppp3ca Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Cep170 ortho Prkar2b Lasp1 ortho P Terf1 Lasp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Actb Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Fxr2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd81 Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map4 Lasp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Slc25a44 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sclt1 Lasp1 ortho G G G G Lasp1 Cxcr1 ortho Ddb1 Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Dnaaf2 ortho Acta1 Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Acd Lasp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkg2 Lasp1 ortho G G G G G G G G G G G Lasp1 Rdh12 ortho G G G G G G G Lasp1 Zbtb9 ortho Lasp1 Lzts2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dctn1 Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Zdhhc17 ortho Arhgef15 Lasp1 ortho Trip13 Lasp1 ortho G G G G G G G G G G G G G G Lasp1 Eif4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wrn Lasp1 ortho G G G G G G G G G G G G G G G G G G G G G G G Ilk Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Hspe1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nfya Lasp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Fyttd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psma3 Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Arfgap1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Dazap2 ortho Fn1 Lasp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lasp1 Sept3 ortho P G G G G G G G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Vasp Lasp1 MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0415(enzymatic study) 15465019,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_167130|UniProt_167133|BIOGRID_328098 neutral component|neutral component|prey neutral component|neutral component|bait Prkg1 Lasp1 MI:0415(enzymatic study) 15465019 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_328093 bait prey Lasp1 Zyx MI:0415(enzymatic study) 15465019 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_328097 bait prey Acta2 Lasp1 MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0415(enzymatic study)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 15465019,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0914(association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (intact)|(intact)|(biogrid)|(intact)|(intact)|(intact)|(intact) UniProt_167130|UniProt_167133|BIOGRID_328100|UniProt_167134|UniProt_167126|UniProt_167116|UniProt_167114 neutral component|neutral component|bait|neutral component|neutral component|neutral component|neutral component neutral component|neutral component|prey|neutral component|neutral component|neutral component|neutral component Prkaca Lasp1 MI:0415(enzymatic study)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 15465019,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|(intact)|(intact) BIOGRID_328094|UniProt_167116|UniProt_167114 bait|neutral component|neutral component prey|neutral component|neutral component Invs Lasp1 MI:0004(affinity chromatography technology) 21565611 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_326986 bait prey Lasp1 Lpp MI:0415(enzymatic study)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 15465019,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|(intact)|(intact)|(intact)|(intact) BIOGRID_328099|UniProt_167130|UniProt_167133|UniProt_167134|UniProt_167126 bait|neutral component|neutral component|neutral component|neutral component prey|neutral component|neutral component|neutral component|neutral component

PPI - HINT Gene A Gene B PMID Method Quality PRKACA LASP1 15465019 0415 LC PRKG1 LASP1 15465019 0415 LC YWHAE LASP1 16615898 0027 LC ACTA2 LASP1 15465019 0401 LC LASP1 PGLS 16615898 0027 LC LASP1 YWHAB 16635246 0029 LC INVS LASP1 21565611,21565611 0004,0007 HT ACTA2 LASP1 15465019 0401 LC VASP LASP1 15465019 0096 LC LASP1 ZYX 15465019 0096 LC LASP1 LPP 15465019 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q61792 P70460 LASP1 VASP 0.309 15465019 Q62523 Q61792 ZYX LASP1 0.309 15465019 Q8BFW7 Q61792 LPP LASP1 0.309 15465019 Q61792 P62259 LASP1 YWHAE 0.081 16615898 Q61792 P0C605 LASP1 PRKG1 0.309 15465019 Q61792 P05132 LASP1 PRKACA 0.309 15465019 Q9CQ60 Q61792 PGLS LASP1 0.081 16615898 Q9CQV8 Q61792 YWHAB LASP1 0.081 16635246 Q61792 P62737 LASP1 ACTA2 0.21 15465019