PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Lepr Socs7 16698021 mint,intact exp G Socs7 Cul5 19385048 biogrid exp, ortho Socs7 Sorbs3 15242778 biogrid exp, ortho G G G G G G G Insr Socs7 ortho G Egfr Socs7 ortho G G G G Pik3r1 Socs7 ortho G G G G G G Grb2 Socs7 ortho G G G G G G G Irs2 Socs7 ortho G G G G Tubb4b Socs7 ortho G G G G G G G Stat3 Socs7 ortho G G G G G G G Socs7 Nck1 ortho G G G G G G G Abi1 Socs7 ortho G G G G G G G Pik3r2 Socs7 ortho G G G G G G G Plcg1 Socs7 ortho Stat5a Socs7 ortho G G G G G G G Irs1 Socs7 ortho G G G G G G Tuba1a Socs7 ortho G G G G G G G Socs7 Sept6 ortho G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8VHQ2 Q9R1Z8 affinity chromatography technology 15242778 physical association X 2 Q8VHQ2 Q9D5V5 pull down 19385048 direct interaction X 2 Q8VHQ2 Q15369-2 biochemical 19385048 association X 2 Q8VHQ2 Q15370-2 biochemical 19385048 association X 2 Q8VHQ2 Q15370-2 x-ray crystallography 19385048 association X 2 Q8VHQ2 Q15369-2 x-ray crystallography 19385048 association X 2 Q8VHQ2 Q15369-2 pull down 19385048 direct interaction X 2 Q8VHQ2 Q15370-2 pull down 19385048 direct interaction X 2 Q8VHQ2 P48356 two hybrid 16698021 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Lepr Socs7 MI:0018(two hybrid)|MI:0018(two hybrid) 16698021 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_166887|MINT_81486 bait|bait prey|prey Socs7 Cul5 MI:0401(biochemical) 19385048 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_319474 prey bait Socs7 Sorbs3 MI:0018(two hybrid) 15242778 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322478 bait prey

PPI - HINT Gene A Gene B PMID Method Quality LEPR SOCS7 16698021 0018 LC SOCS7 CUL5 19385048 0096 LC SOCS7 SORBS3 15242778 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8VHQ2 Q15369 SOCS7 TCEB1 0.416 19385048 Q8VHQ2 Q15370 SOCS7 TCEB2 0.416 19385048 Q9R1Z8 Q8VHQ2 SORBS3 SOCS7 0.21 15242778 Q8VHQ2 P48356 SOCS7 LEPR 0.309 16698021 Q9D5V5 Q8VHQ2 CUL5 SOCS7 0.183 19385048