PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Otud7b Apc 18281465 biogrid exp P G G G G G G G G G G G G G G G G G G G G G G G G G G G Otud7b Ltbr 23334419 biogrid,dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G Otud7b Cd40 23334419 dip exp G G G G G Otud7b Traf3 23334419 biogrid,dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G Otud7b Tnip2 ortho G G G G G G G G Lgr4 Otud7b ortho Otud7b Casp8 ortho P G G G G G G G G G G G G G G G G G G G G G G G Otud7b Hif1an ortho Otud7b Ubc ortho P G G G G G G G G G G G G G G G G G G G G G G G G G G G Otud7b Wwox ortho G G G G G G G G G G G G G G G G G G G Otud7b Traf6 ortho G G G G G G G G G G G G G G G G G G G Otud7b Nup155 ortho P G G G G G G G G G G G G G G G G G G G G G G G G G G G Otud7b Tnfrsf10b ortho Otud7b Ube2s ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Otud7b Acad9 ortho P G G G G G G G G G G G G G G G G G G G G G G G G G G G Otud7b Ywhab ortho P G G G G G G G G G G G G G G G G G G G G G G G G G G G Otud7b Slc9a3r2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Otud7b Zdhhc17 ortho Otud7b Msh3 ortho P G G G G G G G G G G G G G G G G G G G G G G G G G G G Otud7b Egfr ortho P G G G G G G G G G G G G G G G G G Otud7b Park7 ortho P G G G G G G G G G G G G G G G G G G G G G G G G G G G Otud7b Pik3r3 ortho P Otud7b Xpo1 ortho P G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants B2RUR8 affinity chromatography technology 23334419 physical association X 2 Q61315 B2RUR8 two hybrid 18281465 direct interaction X 2 Q61315 B2RUR8 affinity chromatography technology 18281465 physical association X 2 Q3UHJ1 B2RUR8 affinity chromatography technology 23334419 physical association X 2 B2RUR8 affinity chromatography technology 18281465 physical association X 2 P50284 B2RUR8 affinity chromatography technology 23334419 physical association X 2 B2RUR8 anti bait coimmunoprecipitation 23334419 - C 5 B2RUR8 anti bait coimmunoprecipitation 23334419 - C 5 B2RUR8 P25942 anti bait coimmunoprecipitation 23334419 physical association X 2 B2RUR8 P25942 anti bait coimmunoprecipitation 23334419 physical association X 2 B2RUR8 P27512 anti bait coimmunoprecipitation 23334419 physical association X 2 Q60803 B2RUR8 anti bait coimmunoprecipitation 23334419 physical association X 2 B2RUR8 anti bait coimmunoprecipitation 23334419 - C 5 P50284 B2RUR8 anti bait coimmunoprecipitation 23334419 physical association X 2 B2RUR8 anti tag coimmunoprecipitation 21097510 association C 5

PPI - HINT Gene A Gene B PMID Method Quality OTUD7B APC 18281465,18281465 0004,0018 LC OTUD7B CD40 23334419 0006 LC OTUD7B LTBR 23334419,23334419 0006,0004 LC OTUD7B TRAF3 23334419,23334419 0006,0004 LC OTUD7B APC 18281465,18281465 0004,0018 LC