PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Hoxb4 Nfe2 20211142 biogrid exp G G Hoxb4 Meis1 15617687 i2d,intact exp G G G G G Hoxb4 Cul4a 21098278 biogrid exp, ortho G G G G G G Ep300 Hoxb4 ortho Hoxb4 Ddb1 ortho G G G G G G Hoxb4 Crebbp ortho G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P10284 Q60954-2 - 15617687 - X 2 P10284 two hybrid 20211142 direct interaction X 2 P10284 Q3TCH7 two hybrid 21098278 direct interaction X 2 Q60954 P10284 two hybrid 15617687 physical association X 2 P10284 Q60954-2 two hybrid 15617687 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Hoxb4 Cul4a MI:0004(affinity chromatography technology) 21098278 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_320147 bait prey Hoxb4 Meis1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 15617687 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_164162|UniProt_164150 prey|prey null|null Hoxb4 Nfe2 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313189 bait prey

PPI - HINT Gene A Gene B PMID Method Quality HOXB4 NFE2 20211142 0018 HT HOXB4 CUL4A 21098278 0018 LC HOXB4 MEIS1 15617687 0018 LC