PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ywhaz Ube2l3 16615898 intact exp P Ywhae Ube2l3 16615898 intact exp P Ube2l3 Pgls 16615898 intact exp P Ube2l3 Rnf25 10500182 biogrid exp Ube2l3 Rnf144a 10431818 biogrid exp, ortho Ube2l3 Park2 20064468,16096643 biogrid,mint,intact exp, ortho Rnf216 Ube2l3 10431818 biogrid exp, ortho Ube2l3 Rbck1 11722579,10431818 biogrid exp, ortho P Ube2l3 Arih2 11722579,10431818 biogrid exp, ortho P Ube2l3 Wwp2 21170031 biogrid exp, ortho P Ube2l3 Arih1 10431818 biogrid exp, ortho P Rnf19a Ube2l3 10431818 biogrid exp, ortho Ube2l3 Ubox5 10431818 biogrid exp, ortho P Ube2l3 Ube2l3 ortho P Ube2l3 Xiap ortho Ube2l3 Hspa4 ortho P Ube2l3 Tigar ortho P Ube2l3 Rela ortho P Ube2l3 Uba1 ortho P Tp53 Ube2l3 ortho Jun Ube2l3 ortho Ube3a Ube2l3 ortho P Ube2l3 Rnf20 ortho P Ube2l3 Mrpl53 ortho P Vhl Ube2l3 ortho Trip12 Ube2l3 ortho P Ube2l3 Ube2l6 ortho Ube2l3 Traf6 ortho Rab10 Ube2l3 ortho P Ube2l3 Tsnaxip1 ortho Ube2l3 Ubash3a ortho Ube2l3 Sugp1 ortho Ube2l3 Stub1 ortho P Pja1 Ube2l3 ortho Ube2l3 Map1lc3b ortho P Ube2l3 Fbxo2 ortho P Ube2l3 Pck2 ortho Ube2l3 Ube2v2 ortho P Pitpna Ube2l3 ortho P Ube2l3 Psmd2 ortho P Ube2l3 Smurf1 ortho Birc3 Ube2l3 ortho Fn1 Ube2l3 ortho P Ufm1 Ube2l3 ortho P Ube2l3 Rnf144b ortho Ube2l3 Mapk6 ortho P Ube2l3 Nedd4l ortho P Ube2l3 Hspe1 ortho P Ube2l3 Ncoa1 ortho Ube2l3 Ube4b ortho P Ube2l3 Cul9 ortho P Nr3c1 Ube2l3 ortho P Ube2b Ube2l3 ortho P Ube2l3 Trim28 ortho P Ube2l3 Bag3 ortho P Ube2l3 Mul1 ortho Ube2l3 Ndfip1 ortho Ube2l3 Pinx1 ortho Ube2l3 Trim39 ortho Ube2l3 Ndufa7 ortho P Ube2l3 Birc2 ortho Ube2l3 Lig4 ortho Ube2d1 Ube2l3 ortho Myc Ube2l3 ortho Ube2l3 Ube3c ortho P Ptrhd1 Ube2l3 ortho P Ube2l3 Trim21 ortho Ubc Ube2l3 ortho P Ube2l3 Uchl3 ortho P Ube2l3 Ubxn7 ortho P Ube2l3 Ubr5 ortho P Ube2l3 Wwp1 ortho P Ube2l3 Itch ortho P Smurf2 Ube2l3 ortho Ube2l3 Arel1 ortho Ccnb1ip1 Ube2l3 ortho Ube2l3 Psma5 ortho P Ube2l3 Herc3 ortho Ube2l3 Hecw2 ortho Ube2l3 Msi2 ortho P Ube2l3 Mkrn3 ortho Ube2l3 Usp34 ortho P Mdh2 Ube2l3 ortho P Ube2l3 Smad4 ortho P Smad7 Ube2l3 ortho Ube2l3 Eif4e2 ortho P Sod1 Ube2l3 ortho P Casp8 Ube2l3 ortho P Ube2l3 Ahcyl1 ortho P Ube2l3 Rnf103 ortho Ube2d2 Ube2l3 ortho P Fos Ube2l3 ortho Polr2a Ube2l3 ortho Ube2l3 Aicda ortho Nfkb1 Ube2l3 ortho P Ube2l3 Rnf2 ortho P Brca1 Ube2l3 ortho Ube2l3 Nfkbia ortho P Ube2l3 Pir ortho P Ube2l3 Dtx3 ortho Epb41 Ube2l3 ortho P Ube2l3 Traf7 ortho Mid1 Ube2l3 ortho Ube2l3 Atxn3 ortho P Ube2l3 Mmachc ortho Ube2l3 Usp9x ortho P Yap1 Ube2l3 ortho P Pten Ube2l3 ortho P Ube2l3 Usp26 ortho Cacna1b Ube2l3 ortho Ube2l3 Prkab1 ortho P Ube2l3 Tp53bp1 ortho P Ube2l3 Cblc ortho Ube2l3 Ubxn1 ortho P Snx12 Ube2l3 ortho P Ube2l3 Aurka ortho Ube2l3 MCG18845, isoform CRA_d, Protein Uba7, Ubiquitin-activating enzyme E1-like ortho Cbl Ube2l3 ortho Ube2l3 Map1lc3a ortho P Ube2l3 Hace1 ortho Ube2l3 Eif1b ortho P Mdm2 Ube2l3 ortho Ube2l3 Elavl1 ortho P Ube2l3 Vdac2 ortho P Ube2l3 Zpr1 ortho P Rnf19b Ube2l3 ortho Ube2l3 Uba6 ortho P Snx3 Ube2l3 ortho P Ube2l3 Hebp1 ortho Ube2l3 Ube2a ortho P Ube2l3 Rpl19 ortho P Srprb Ube2l3 ortho P Ube2l3 Huwe1 ortho P Ube2l3 Rnf31 ortho P Ube2l3 Mycbp2 ortho P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P68037 - 10431818 - X 2 P68037 Q9Z1K6 - 10431818 - X 2 P68037 P50876 two hybrid 11722579 direct interaction X 2 P68037 P50876 affinity chromatography technology 10431818 physical association X 2 P68037 P50636 two hybrid 10431818 direct interaction X 2 P68037 Q925F3 two hybrid 10431818 direct interaction X 2 P68037 A4V4Q7 two hybrid 10880484 direct interaction X 2 P68037 Q9WUB0 two hybrid 11722579 direct interaction X 2 P68037 Q9Z1K6 two hybrid 11722579 direct interaction X 2 P68037 Q9Z1K6 affinity chromatography technology 11722579 physical association X 2 P68037 Q9QZR0 two hybrid 10500182 direct interaction X 2 P68037 O94941-2 affinity chromatography technology 11274149 physical association X 2 P68037 Q9WUB0 affinity chromatography technology 10431818 physical association X 2 P68037 Q9Z1K6 affinity chromatography technology 10431818 physical association X 2 P68037 P58283-2 two hybrid 10431818 direct interaction X 2 P68037 Q9Z1K5 two hybrid 10431818 direct interaction X 2 P68037 Q9Z1K6 two hybrid 10431818 direct interaction X 2 P68037 Q9WUB0 two hybrid 10431818 direct interaction X 2 P68037 Q925F4 two hybrid 10431818 direct interaction X 2 P68037 cosedimentation 16615898 colocalization C 1216 P68037 Q9WVS6 anti tag coimmunoprecipitation 16096643 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ube2l3 Arih1 MI:0004(affinity chromatography technology)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 10431818,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|(intact)|(intact) BIOGRID_311824|UniProt_167134|UniProt_167114 bait|neutral component|neutral component prey|neutral component|neutral component Ube2l3 Arih2 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 10431818,11722579 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_322118|BIOGRID_311820|BIOGRID_311825|BIOGRID_322121 bait|bait|bait|bait prey|prey|prey|prey Ube2l3 Rnf144a MI:0004(affinity chromatography technology) 10431818 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_311828 bait prey Ube2l3 Ubox5 MI:0004(affinity chromatography technology) 10431818 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_311829 bait prey Ube2l3 Rbck1 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10431818,11722579 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_322117|BIOGRID_311827|BIOGRID_311819 bait|bait|bait prey|prey|prey Rnf19a Ube2l3 MI:0004(affinity chromatography technology) 10431818 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_311826 prey bait Ube2l3 Park2 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 16096643 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_165544|MINT_81607 prey|prey bait|bait Rnf216 Ube2l3 MI:0004(affinity chromatography technology) 10431818 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_311823 prey bait

PPI - HINT Gene A Gene B PMID Method Quality RNF19A UBE2L3 10431818 0018 LC RNF216 UBE2L3 10431818 0018 LC YWHAE UBE2L3 16615898 0027 LC YWHAZ UBE2L3 16615898 0027 LC UBE2L3 RNF144A 10431818 0018 LC UBE2L3 UBOX5 10431818 0018 LC UBE2L3 PGLS 16615898 0027 LC UBE2L3 RNF25 10500182 0018 LC UBE2L3 RBCK1 10431818,11722579,10431818 0018,0018,0004 LC UBE2L3 ARIH1 10431818 0018 LC UBE2L3 ARIH2 11722579,11722579,10431818,10431818 0004,0018,0004,0018 LC RNF216 UBE2L3 24945773 0096 LC UBE2L3 WWP2 21170031 0096 LC UBE2L3 RBCK1 10431818,10431818 0018,0004 LC UBE2L3 PARK2 20064468,16096643 0096,0007 LC UBE2L3 ARIH2 11722579,11722579,10431818,10431818 0004,0018,0004,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P68037 P62259 UBE2L3 YWHAE 0.081 16615898 Q9WVS6 P68037 PARK2 UBE2L3 0.309 20064468 P68037 P50876 UBE2L3 RNF144A 0.454 10431818,11722579 Q9WUB0 P68037 RBCK1 UBE2L3 0.623 10431818,11722579 Q9Z1K6 P68037 ARIH2 UBE2L3 0.702 10431818,11722579 Q9CQ60 P68037 PGLS UBE2L3 0.081 16615898 Q9DBH0 P68037 WWP2 UBE2L3 0.309 21170031 Q925F4 P68037 UBOX5 UBE2L3 0.309 10431818 Q925F3 P68037 RNF144A UBE2L3 0.309 10431818 P68037 P58283 UBE2L3 RNF216 0.523 10431818,24945773 Q94981 P68037 ARI-1 UBE2L3 0.309 10880484 P68037 O94941 UBE2L3 UBOX5 0.21 11274149 Q9Z1K5 P68037 ARIH1 UBE2L3 0.309 10431818 Q9QZR0 P68037 RNF25 UBE2L3 0.309 10500182 P68037 P50636 UBE2L3 RNF19A 0.309 10431818 P68037 O60260 UBE2L3 PARK2 0.21 16096643 P68037 P63101 UBE2L3 YWHAZ 0.081 16615898