PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Itpr1 Nploc4 16103111 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Vcp 17491009,10811609 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Mrps9 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Eif4a3 ortho P Nploc4 Pde12 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rrm2 Nploc4 ortho G G G G G G G G G G G G G G G G G G G G G G Dnaaf5 Nploc4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ubxn10 ortho G G G G G G Nploc4 Atp6v1b2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Nsfl1c ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Elavl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Faf2 ortho P Nploc4 Ppp2cb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Etnk2 Nploc4 ortho Nploc4 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ezh2 ortho G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ndufs3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Meis1 ortho GP G G G G G G G G G G G G G G Nploc4 Mtmr12 ortho Nploc4 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Cep128 ortho Nploc4 Asns ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Fkbp10 ortho G G G G G G G G G G G G G G Nploc4 Rprd1b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Flot1 Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Tmem62 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lmna Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ubxn6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ssb Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gzmk Nploc4 ortho G G G Nploc4 Sh3kbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Sae1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sprtn Nploc4 ortho Nploc4 Dr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Hnrnpl ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ubxn7 ortho P Nploc4 Hnrnpk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E2f3 Nploc4 ortho G G G G G Nploc4 Mppe1 ortho Cap1 Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Zfand1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Amfr ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ptch1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dctn1 Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ubxn11 ortho G G G G G G G G G G Nploc4 Camk1d ortho P G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Raf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Nfkbia ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Mettl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Yod1 ortho Ccnd2 Nploc4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG5959, isoform CRA_a, Protein Kcnk16 Nploc4 ortho Nploc4 Usp13 ortho G G G G G G Nploc4 Aspscr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Heterogeneous nuclear ribonucleoprotein R, Protein Hnrnpr ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pkm Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Pdlim5 ortho GP G G G G G G G G G G G G Cdc25a Nploc4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrb2 Nploc4 ortho G G G G G G G G G Nploc4 Zfand2b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Mrpl19 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Uba2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Dpp9 ortho P Nploc4 Coq6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Vimp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad23b Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mov10 Nploc4 ortho G G G G G G G G G G G G G G G G G G G G Map3k1 Nploc4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Uba1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Armc9 ortho Nploc4 Vcpip1 ortho Nploc4 Lpp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk5 Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Plaa Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ccnh ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ptprf Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccng1 Nploc4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ufm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Smad1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adsl Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Rpa2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ubqln2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Gars ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Wdr4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ntrk1 ortho Surf2 Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G Nploc4 Picalm ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Rprd1a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Svip ortho MCG16402, Protein Slc38a6 Nploc4 ortho Nploc4 Hecw2 ortho Nploc4 Plin3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ngdn ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Mtpn ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Srp14 Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P0CG48 P60670 affinity chromatography technology 12411482 physical association X 2 P11881 P60670 affinity chromatography technology 16103111 physical association X 2 P60670 P0CG50 pull down 12411482 direct interaction X 2 P60670 enzymatic study 25260751 direct interaction X 2 Q01853 P60670 pull down 17491009 direct interaction X 2 Q01853 P60670 affinity chromatography technology 10811609 physical association X 2 P60670 anti bait coimmunoprecipitation 16103111 association C 4

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Nploc4 Vcp MI:0096(pull down)|MI:0004(affinity chromatography technology) 10811609,17491009 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_324233|BIOGRID_327824 bait|prey prey|bait Ubc Nploc4 MI:0004(affinity chromatography technology) 12411482 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_322259 bait prey Itpr1 Nploc4 MI:0004(affinity chromatography technology) 16103111 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319865 bait prey

PPI - HINT Gene A Gene B PMID Method Quality NPLOC4 VCP 17491009,17491009 0096,0114 LC ITPR1 NPLOC4 16103111 0004 LC RAB21 NPLOC4 26885862 0676 LC RAB18 NPLOC4 26885862 0676 LC RAB19 NPLOC4 26885862 0676 LC NPLOC4 VCP 17491009,10811609,17491009 0096,0004,0114 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P60670 P11881 NPLOC4 ITPR1 0.21 16103111 P60670 P35282 NPLOC4 RAB21 0.126 26885862 P60670 P35293 NPLOC4 RAB18 0.126 26885862 P60670 P35294 NPLOC4 RAB19 0.126 26885862 Q01853 P60670 VCP NPLOC4 0.454 10811609,17491009