PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Cbl Ddx58 23374343 intact exp Rpl8 Ddx58 23553835 innatedb exp P Rpl13 Ddx58 23553835 innatedb exp P Ddx58 Siglec10 23374343 innatedb,intact exp MCG11385, Protein Ddx60 Ddx58 21791617 biogrid exp P Rpl3 Ddx58 23553835 innatedb exp P Ptpn11 Ddx58 23374343 intact exp P Tank Ddx58 21419663 innatedb exp Ddx58 Mavs 21703540 innatedb exp, ortho P Ddx58 Tbk1 18977754,23950712 innatedb,biogrid exp, ortho P Trim25 Ddx58 24015671,23209422 biogrid exp, ortho P Ddx58 Dhx58 ortho Ddx58 Pccb ortho P Ddx58 Prkrir ortho Hspd1 Ddx58 ortho P Casp8 Ddx58 ortho P Ddx58 Usp15 ortho P Ddx58 Tspan10 ortho Prkca Ddx58 ortho P Gpkow Ddx58 ortho Src Ddx58 ortho Ddx58 Vapa ortho P Dusp11 Ddx58 ortho Ddx58 Rnf135 ortho Ddx58 Ikbke ortho Ube2d1 Ddx58 ortho Ddx58 Atg5 ortho P Atp5b Ddx58 ortho P Nlrc5 Ddx58 ortho G3bp1 Ddx58 ortho P Ddx58 St13 ortho P Snrnp200 Ddx58 ortho P Ddx58 Gbe1 ortho P Cct2 Ddx58 ortho P Ddx58 Pycard ortho P Copb2 Ddx58 ortho P Rps13 Ddx58 ortho P Ddx58 Prkra ortho P Birc2 Ddx58 ortho Ubc Ddx58 ortho P Tubb4b Ddx58 ortho P Ddx58 Ppp1r3a ortho Ddx58 Atg12 ortho Ddx58 Rnf31 ortho P Stat1 Ddx58 ortho P Zc3hav1 Ddx58 ortho P Traf3 Ddx58 ortho Snrpd1 Ddx58 ortho P Taf6 Ddx58 ortho Ddx58 Trim32 ortho P Ddx58 Rai14 ortho P Dld Ddx58 ortho P Pcbp1 Ddx58 ortho P Ddx58 Ddx58 ortho P Ddx58 Tktl2 ortho Casp1 Ddx58 ortho P Snrpn Ddx58 ortho P Rnf5 Ddx58 ortho Prkcg Ddx58 ortho Ddx58 Rbck1 ortho P Ddx58 Map3k14 ortho Isg15 Ddx58 ortho P Ddx58 Psmd13 ortho P Trim71 Ddx58 ortho Pc Ddx58 ortho P Tnfaip3 Ddx58 ortho Ddx58 Eri1 ortho Hspe1 Ddx58 ortho P Ddx58 Cyld ortho Trove2 Ddx58 ortho P Tcp1 Ddx58 ortho P Ddx58 Casp9 ortho Npepps Ddx58 ortho P Tia1 Ddx58 ortho P Ube2k Ddx58 ortho P Ddx58 Wrnip1 ortho P Ddx58 Usp3 ortho Ddx58 Cc2d1a ortho P Cct8 Ddx58 ortho P Irf3 Ddx58 ortho P Tial1 Ddx58 ortho P Ddx58 Azi2 ortho Pcbp2 Ddx58 ortho P Mbp Ddx58 ortho P Ddx58 Usp21 ortho Ube2d3 Ddx58 ortho P Tmem173 Ddx58 ortho Gcdh Ddx58 ortho P Ddx58 Nod2 ortho Ddx3x Ddx58 ortho P Prkcb Ddx58 ortho P Ddx58 Ctsz ortho P Elavl1 Ddx58 ortho P Eef2 Ddx58 ortho P Rps12 Ddx58 ortho P Ddx58 Sec14l1 ortho P Ikbkg Ddx58 ortho P Ube2d2 Ddx58 ortho P Mex3c Ddx58 ortho Cct7 Ddx58 ortho P Usp4 Ddx58 ortho P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6Q899 affinity chromatography technology 21791617 physical association X 2 P0CG48 Q6Q899 affinity chromatography technology 24015671 physical association X 2 Q6Q899 P0CG50 affinity chromatography technology 23209422 physical association X 2 Q6Q899 Q14258 enzymatic study 23209422 direct interaction X 2 Q6Q899 Q61510 enzymatic study 23209422 direct interaction X 2 Q6Q899 Q9CWS1 enzymatic study 23209422 direct interaction X 2 Q6Q899 Q9WUN2 affinity chromatography technology 23950712 physical association X 2 Q6Q899 Q61510 affinity chromatography technology 24015671 physical association X 2 Q6Q899 anti tag coimmunoprecipitation 23374343 association C 3 Q80ZE3 Q6Q899 anti tag coimmunoprecipitation 23374343 physical association X 2 Q80ZE3 Q6Q899 confocal microscopy 23374343 colocalization X 2 Q80ZE3 Q6Q899 anti tag coimmunoprecipitation 23374343 physical association X 2 P22682 Q6Q899 anti tag coimmunoprecipitation 23374343 physical association X 2 P22682 Q6Q899 confocal microscopy 23374343 colocalization X 2 Q6Q899 anti tag coimmunoprecipitation 23374343 association C 4 Q6Q899 anti bait coimmunoprecipitation 23374343 association C 4 Q6Q899 anti tag coimmunoprecipitation 23374343 association C 4 Q6Q899 anti bait coimmunoprecipitation 23374343 association C 4 Q6Q899 anti tag coimmunoprecipitation 23374343 association C 4

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ubc Ddx58 MI:0004(affinity chromatography technology) 23209422 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325044 prey bait Ddx58 Ddx60 MI:0004(affinity chromatography technology) 21791617 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316078 bait prey Cbl Ddx58 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 23374343 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization) (intact)|(intact) UniProt_174665|UniProt_174671 prey|neutral component bait|neutral component Ddx58 Rnf135 MI:0004(affinity chromatography technology) 23209422 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_325048 prey bait Ddx58 Tbk1 MI:0004(affinity chromatography technology) 23950712 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_331436 bait prey Ddx58 Siglecg MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 23374343 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_174663|UniProt_174675|UniProt_174673|UniProt_174668|UniProt_174669|UniProt_174664|UniProt_174672|UniProt_174666|UniProt_174667 prey|prey|prey|bait|prey|bait|neutral component|bait|bait bait|prey|prey|prey|bait|prey|neutral component|prey|prey Trim25 Ddx58 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23209422,24015671 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_325046|BIOGRID_331605 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality DDX60 DDX58 21791617 0004 LC CBL DDX58 23374343,23374343 0007,0663 LC PTPN11 DDX58 23374343,23374343 0007,0006 LC TANK DDX58 21419663 0007 LC TRIM25 DDX58 23209422,24015671 0004,0004 LC DDX58 SIGLECG 23374343,23374343 0007,0663 LC DDX58 TBK1 18977754,23950712 0007,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6Q899 Q61510 DDX58 TRIM25 0.376 24015671,23209422 Q6Q899 P0CG48 DDX58 UBC 0.21 24015671 Q6Q899 Q14258 DDX58 TRIM25 0.21 23209422 Q80ZE3 Q6Q899 SIGLECG DDX58 0.569 23374343 Q9WUN2 Q6Q899 TBK1 DDX58 0.21 23950712 Q6Q899 P22682 DDX58 CBL 0.454 23374343 Q6Q899 P35235 DDX58 PTPN11 0.376 23374343