PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Myl6 Usp45 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp45 Nkd2 ortho G G 2900073G15Rik Usp45 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tgfbr1 Usp45 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Safb Usp45 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wiz Usp45 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp45 Gsk3b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp45 Smurf1 ortho Csnk1a1 Usp45 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myh10 Usp45 ortho Usp45 Pik3cg ortho G G G G G G G G G G G G Usp45 Rbmx ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp45 Csnk1e ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG2065, isoform CRA_c, PreS1 binding protein, Protein Gltscr2 Usp45 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Polr2g Usp45 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Axin2 Usp45 ortho G G G G G G G G G G G G G G G G G G G G G G G Usp45 RtcA ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bmpr1b Usp45 ortho G G G Ppp5c Usp45 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp45 Fars2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zfr Usp45 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk1 Usp45 ortho G G G G G G G G G G G G G G G G G G G G G Smad1 Usp45 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp45 Tmod3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp45 Ylpm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp45 Myh9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Srbd1 Usp45 ortho Flna Usp45 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Raly Usp45 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dvl2 Usp45 ortho G G G G G G G G G G G G Usp45 Coro1c ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp45 Nkd1 ortho G G G G G G Usp45 Rbm7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8K387 P36897 affinity chromatography technology 15761153 physical association X 2 O00238 Q8K387 affinity chromatography technology 15761153 physical association X 2 Q8K387 affinity chromatography technology 15761153 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9HCE7 Q8K387 SMURF1 USP45 0.126 15761153 Q8K387 P07903 USP45 ERCC1 0.21 25538220 Q8K387 Q6P1D7 USP45 SLX4 0.21 25538220 Q8K387 P36897 USP45 TGFBR1 0.126 15761153 Q8K387 O00238 USP45 BMPR1B 0.126 15761153