PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Nanog Fbxw4 24793005 biogrid exp Fbxw4 Skp1 11735228 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw4 Cul1 11735228 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw4 Pfdn5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct3 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc37 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp5h Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ruvbl1 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct2 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G A2mp Fbxw4 ortho G G G G G G G G G G Cct6a Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops5 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx5 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct8 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r1a Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r1b Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pdrg1 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dctn1 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tcp1 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rcan1 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pdcl Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct4 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mcm4 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pfdn1 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops3 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf32 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G Cct6b Fbxw4 ortho G G Slc25a11 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Heterogeneous nuclear ribonucleoprotein R, Protein Hnrnpr Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Slx4ip Fbxw4 ortho Cct5 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dhx9 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhah Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops4 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops6 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct7 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops8 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops7a Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG21756, isoform CRA_b, Nup205 protein, Protein Nup205 Fbxw4 ortho Nlk Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rest Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psma2 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pdcl3 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Txndc9 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw4 Ecsit ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw4 Mast1 ortho G G G G G G G G G G G G G G Gps1 Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Skiv2l, Superkiller viralicidic activity 2-like (S. cerevisiae) Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Cops7b Fbxw4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9JMJ2 Q9WTX5 affinity chromatography technology 11735228 physical association X 2 P0CG63 Q9JMJ2 pull down 21070969 direct interaction X 2 Q9JMJ2 Q9WTX6 affinity chromatography technology 11735228 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Fbxw4 Skp1 MI:0004(affinity chromatography technology) 11735228 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325911 bait prey Fbxw4 Cul1 MI:0004(affinity chromatography technology) 11735228 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325906 bait prey

PPI - HINT Gene A Gene B PMID Method Quality NANOG FBXW4 24793005 0004 LC FBXW4 SKP1 11735228 0004 LC FBXW4 CUL1 11735228 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9WTX5 Q9JMJ2 SKP1 FBXW4 0.21 11735228 Q9WTX6 Q9JMJ2 CUL1 FBXW4 0.21 11735228 Q9JMJ2 P0CG63 FBXW4 UBI4 0.309 21070969 Q9JMJ2 Q80Z64 FBXW4 NANOG 0.21 24793005