PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ywhaz Wwp1 19562802 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf6 Wwp1 23799152 biogrid exp G G G G G G G G G G G G G G G G G G G G Hoxd12 Wwp1 20211142 biogrid exp Runx2 Wwp1 ortho G G G G G G G G G G G G G Atn1 Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkg Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fam189a2 Wwp1 ortho Wwp1 Fbxl15 ortho G G G G G G G G G G G G G G G G G G G Wwp1 Dazap2 ortho Dnm1 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G Laptm5 Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Fbxl18 Wwp1 ortho Wwp1 Pdpk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tgif1 Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G Sftpc Wwp1 ortho G G G G G G G G G Smad4 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp1 Arrdc2 ortho Smad7 Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Il6ra Wwp1 ortho G G G G G G G G G G G G G G G Klf2 Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp1 Itsn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Hivep3 Wwp1 ortho G Tmem255a Wwp1 ortho Ptch1 Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp1 Eps8l1 ortho G G G G G G G G G Wwp1 Tmem51 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp1 Sucla2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Setd4 Wwp1 ortho G G G G G G G G Wwp1 Hid1 ortho P G G G G G G G G G G G G G G G G G G G G Wwp1 Tp53bp2 ortho P Tmem255b Wwp1 ortho Stat6 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Cpsf6 Wwp1 ortho P Ldb2 Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Arrdc3 Wwp1 ortho Wwp1 Clcn5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Laptm4a Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp1 Phf20l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp1 Mlycd ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp1 Klf5 ortho G G G G G G G G G G G G G G G G G G G G G G G G Scnn1a Wwp1 ortho G G G G G G G G G G G G G G G G G G Ddx3y Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Prkaa2 Wwp1 ortho P Lats1 Wwp1 ortho P G G G G G G G G G G G Hspb1 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Notch1 Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad6 Wwp1 ortho G G G G G G G G G G G G G G G G G G G G Wwp1 Scnn1g ortho G G Ptpn14 Wwp1 ortho G Hsp90aa1 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp63 Wwp1 ortho G G G G G G G Ube2l3 Wwp1 ortho P Smad2 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp1 H2afy2 ortho P G G G G G G G G G G G Wwp1 Map1lc3a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr2 Wwp1 ortho G Wwp1 Nedd4l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pcbd1 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G Tfap2a Wwp1 ortho G G G G G G Wwp1 Arrdc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nfe2 Wwp1 ortho G G G G Wwp1 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp1 Ash2l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dag1 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90ab1 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Erbb4 Wwp1 ortho P Ldlrad4 Wwp1 ortho G Pten Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wbp1 Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ezr Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad3 Wwp1 ortho G G G G G G G G G G G G G G G Wwp1 Rhoh ortho G G G G Znf638 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ezh2 Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G Wwp1 Cog4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc37 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Rasa1 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Xrcc5 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Lnx1 Wwp1 ortho G G G G G G G G G G G G G G G G G G G G Katnb1 Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Smad1 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dvl2 Wwp1 ortho G G G G G G G G G G G G Lck Wwp1 ortho G G G G G G G G G G G G G G Wwp1 Lztr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp1 Dido1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad5 Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Skil Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wbp2 Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sgta Wwp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp1 Nudt6 ortho G G G G G G G G G G G G G Il2rg Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G Wwp1 Pygm ortho GP G G G G G G G G G G G G G G G G G G G Pax6 Wwp1 ortho G G G G G Wwp1 Rtn4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fam189b Wwp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Traf4 Wwp1 ortho G G G G G G G G G G G G G G G G G G Wwp1 Cdk8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P23812 Q8BZZ3 two hybrid 20211142 direct interaction X 2 Q8BZZ3 P70196 affinity chromatography technology 23799152 physical association X 2 Q8BZZ3 cosedimentation in solution 19562802 association C 137

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8BZZ3 P23812 WWP1 HOXD12 0.183 20211142 Q8BZZ3 P70196 WWP1 TRAF6 0.21 23799152 Q8BZZ3 P63101 WWP1 YWHAZ 0.126 19562802