PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Stat1 Fbxo2 18378670 biogrid exp P G G G G G G G G G G Dlg4 Fbxo2 19455133 intact exp P G G G G G G G G G Grin1 Fbxo2 17494702 innatedb exp, ortho G G G G G G G G Bace1 Fbxo2 20854419 biogrid exp, ortho G G G G G G G G G Fbxo2 Skp1 17215248,17494702 innatedb,biogrid exp, ortho P G G G G G G G G G G Vcp Fbxo2 15723043 biogrid exp, ortho P G G G G G G G G G G Fbxo2 Cul1 17215248 biogrid exp, ortho P G G G G G G G G G G Fbxo2 Slamf7 ortho G Ube2l3 Fbxo2 ortho P Fbxo2 Stub1 ortho P G G G G G G G G G G Ecm29 Fbxo2 ortho P G G G G G G G G G G Mapk3 Fbxo2 ortho P G G G G G G G G G G Fbxo2 Anapc2 ortho P G G G G G G G G G G Ube2d1 Fbxo2 ortho G G G G G G G G G G Mgmt Fbxo2 ortho P G Fbxo2 Cul7 ortho P G G G G G G G G G G Fbxo2 Pvrl3 ortho G G G G G G G G G G Fbxo2 Tor1a ortho P G G G G G G G G G Itgb1 Fbxo2 ortho P G G G G G G G G G G Fbxo2 Iqcb1 ortho Fbxo2 Ero1lb ortho P G G G G G G G G G G Ube2e1 Fbxo2 ortho P G G G G G G G G G G Fbxo2 St6galnac5 ortho G G G G G G G Ahsg Fbxo2 ortho P G Ube2d2 Fbxo2 ortho P G G G G G G G G G G Gjb2 Fbxo2 ortho G G G G G G Fbxo2 Ntm ortho G G G G G G Ube2d3 Fbxo2 ortho P G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q80UW2 Q9WTX6 affinity chromatography technology 17215248 physical association X 2 Q80UW2 Q9WTX5 affinity chromatography technology 17215248 physical association X 2 Q80UW2 Q9WTX5 biochemical 17215248 colocalization X 2 Q80UW2 Q9WTX5 affinity chromatography technology 17494702 physical association X 2 Q80UW2 Q8C3V4 affinity chromatography technology 18378670 physical association X 2 Q80UW2 Q8C4F4 affinity chromatography technology 20854419 physical association X 2 Q01853 Q80UW2 affinity chromatography technology 15723043 physical association X 2 Q80UW2 anti tag coimmunoprecipitation 12140560 association C 4 Q80UW2 P61823 molecular sieving 17389369 direct interaction X 2 Q80UW2 P61823 x-ray crystallography 17389369 direct interaction X 2 P63208 Q80UW2 molecular sieving 17389369 direct interaction X 2 P63208 Q80UW2 ion exchange chromatography 17389369 direct interaction X 2 P63208 Q80UW2 pull down 17389369 direct interaction X 2 P63208 Q80UW2 x-ray crystallography 17389369 direct interaction X 2 Q80UW2 anti tag coimmunoprecipitation 19455133 association C 38

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Bace1 Fbxo2 MI:0004(affinity chromatography technology) 20854419 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316042 bait prey Fbxo2 Cul1 MI:0004(affinity chromatography technology) 17215248 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321638 bait prey Fbxo2 Skp1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17215248,17494702 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_321640|BIOGRID_321639|BIOGRID_321751 bait|bait|bait prey|prey|prey Vcp Fbxo2 MI:0004(affinity chromatography technology) 15723043 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_313847 prey bait

PPI - HINT Gene A Gene B PMID Method Quality FBXO2 FBXO2 27487926 0114 LC FBXO2 SKP1 17215248,17215248 0004,0401 LC SYNGAP1 FBXO2 27507650 0004 LC GRIN1 FBXO2 17494702 0007 LC STAT1 FBXO2 18378670 0004 LC BACE1 FBXO2 20854419 0004 LC VCP FBXO2 15723043 0004 LC DLG4 FBXO2 19455133 0007 LC FBXO2 DLGAP1 27507650 0004 LC FBXO2 SKP1 17215248,17215248,17494702,17494702 0004,0401,0007,0004 LC FBXO2 CUL1 17215248 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q80UW2 P56818 FBXO2 BACE1 0.21 20854419 Q80UW2 Q62108 FBXO2 DLG4 0.236 19455133 Q80UW2 Q01853 FBXO2 VCP 0.21 15723043 Q9WTX6 Q80UW2 CUL1 FBXO2 0.21 17215248 Q9WTX5 Q80UW2 SKP1 FBXO2 0.454 17215248,17494702 Q9D415 Q80UW2 DLGAP1 FBXO2 0.126 27507650 Q80UW2 F6SEU4 FBXO2 SYNGAP1 0.126 27507650