PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Znrf3 Znrf3 24349440 biogrid exp Znrf3 Rspo2 24225776 biogrid exp, ortho Lrp6 Znrf3 ortho Znrf3 Fzd4 ortho Ube2n Znrf3 ortho Rspo3 Znrf3 ortho Gfi1b Znrf3 ortho Lgr4 Znrf3 ortho Hspb1 Znrf3 ortho Znrf3 Dvl2 ortho Znrf3 Rspo1 ortho Znrf3 Fzd6 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q5SSZ7 Q5SSZ7 x-ray crystallography 24349440 association X 2 Q5SSZ7 Q8BFU0 x-ray crystallography 24225776 association X 2 Q5SSZ7 Q5UE90 x-ray crystallography 24225776 association X 2 Q5SSZ7 O75473 pull down 24225776 direct interaction X 2 Q5SSZ7 Q2MKA7-2 x-ray crystallography 24349440 association X 2

PPI - HINT Gene A Gene B PMID Method Quality ZNRF3 ZNRF3 24225776,24349440 0114,0114 LC ZNRF3 RSPO2 24225776,26123262 0114,0114 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5SSZ7 Q2MKA7 ZNRF3 RSPO1 0.309 24349440 Q5SSZ7 Q5SSZ7 ZNRF3 ZNRF3 0.332 24349440 Q5UE90 Q5SSZ7 RSPO2 ZNRF3 0.309 24225776 Q8BFU0 Q5SSZ7 RSPO2 ZNRF3 0.309 24225776 Q5SSZ7 O75473 ZNRF3 LGR5 0.309 24225776