PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Morf4l1 Kdm5b 21448134 biogrid,mint,intact exp Sin3a Kdm5b 21448134 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Suz12 Kdm5b 23850221 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac1 Kdm5b 21448134 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Grin2b Kdm5b ortho G G G G G Cacna1a Kdm5b ortho G G G G G G Rbm15b Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Myc Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G Kdm5b Slitrk3 ortho Elavl1 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Abca4 Kdm5b ortho G G G G G G Ar Kdm5b ortho G G G G G G G G G G G G G G G G Wnt3a Kdm5b ortho G Kdm5b Mbd3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cav1 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dbnl Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pald1 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G Kdm5b Spdef ortho G G G G G G G G Rnf43 Kdm5b ortho G G G G G G G G Hdac4 Kdm5b ortho Protein Chd3 Kdm5b ortho Kdm1a Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbbp7 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vgll3 Kdm5b ortho Protein Arid1b Kdm5b ortho Kdm5b Cecr6 ortho G G G Kdm5b Eed ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm5b Dnajb12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ptgis Kdm5b ortho G G G G G G G G G G G G G G G G G G G Kdm5b Actbl2 ortho Meox2 Kdm5b ortho G G G G G G G G G G Hoxa1 Kdm5b ortho G Kdm5b Nr4a3 ortho Foxc2 Kdm5b ortho G G Ppp1ca Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Maf Kdm5b ortho G Prdm13 Kdm5b ortho Kdm5b Gtf2a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbbp4 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Zfp217, Zinc finger protein 217 Kdm5b ortho Rb1 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm5b Hdac7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm5b Pcnx ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdx2 Kdm5b ortho G G G G G Ezh2 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G Shox2 Kdm5b ortho Kdm5b Mta3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cacna1h Kdm5b ortho G G G G G G G G G G G G G G G Elf3 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G Kdm5b Prpf4 ortho Kdm5b Bmp2k ortho G G G G G G G G G G G G G G G G G G G G G G G G G Chst3 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm5b Calm4 ortho G G G G G Onecut2 Kdm5b ortho Dgkq Kdm5b ortho G G G G G G G G G G G G G G G G Kdm5b Mbd2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctgf Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac2 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smarcc2 Kdm5b ortho Klf10 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hist1h3b, Hist1h3c, Hist1h3d, Hist1h3e, Hist1h3f, Hist2h3b, Hist2h3c1, Hist2h3c2 Kdm5b ortho G G G G Cdc14a Kdm5b ortho Pax9 Kdm5b ortho G G Axin2 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G Kdm5b Slc39a6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm5b Hdac5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctcf Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Foxg1 Kdm5b ortho G G G Fbxw11 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esrp1 Kdm5b ortho G G G G G G G G G G G G G G G G Kdm5b Rhobtb2 ortho G G G G G G G G G G G G G G G Kdm5b Taf2 ortho Cldn1 Kdm5b ortho G G G G G G G G G G G G G G G G Brca1 Kdm5b ortho G G G G G G G G G G G G G Fst Kdm5b ortho G G G G G G G G G Kdm5b Rcor1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tgfb2 Kdm5b ortho G G G G G G G G G G G G G G Tfap2c Kdm5b ortho G G G G G Kdm5b Cdc20 ortho G G G G G G G G G G G G G G G G G G G G G G Ncor1 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm5b Elf4 ortho G G G G G G Kdm5b Mta2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lmo2 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q80Y84 affinity chromatography technology 21448134 physical association X 2 Q80Y84 affinity chromatography technology 21448134 physical association X 2 O09106 Q80Y84 affinity chromatography technology 21448134 physical association X 2 O09106 Q80Y84 affinity chromatography technology 21448134 physical association X 2 Q80Y84 Q60520 affinity chromatography technology 21448134 physical association X 2 Q80Y84 Q60520 affinity chromatography technology 21448134 physical association X 2 P60762 Q80Y84 anti bait coimmunoprecipitation 21448134 physical association X 2 P60762 Q80Y84 anti bait coimmunoprecipitation 21448134 physical association X 2 P60762 Q80Y84 anti bait coimmunoprecipitation 21448134 physical association X 2 P60762 Q80Y84 anti bait coimmunoprecipitation 21448134 physical association X 2 P68432 Q80Y84 demethylase assay 17320160 demethylation reaction X 2 Q80Y84 anti bait coimmunoprecipitation 21448134 association C 3 Q80Y84 anti bait coimmunoprecipitation 21448134 association C 3 Q80Y84 anti bait coimmunoprecipitation 21448134 association C 3

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Sin3a Kdm5b MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 21448134 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (biogrid)|(biogrid)|(intact)|(intact)|(intact) BIOGRID_319956|BIOGRID_319952|UniProt_173552|UniProt_173551|UniProt_173550 bait|prey|bait|prey|prey prey|bait|prey|prey|bait Kdm5b Kdm5b MI:0870(demethylase assay)|MI:0870(demethylase assay) 17320160 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0871(demethylation reaction)|MI:0871(demethylation reaction) (intact)|(intact) UniProt_166369|UniProt_89734 unspecified role|unspecified role unspecified role|unspecified role Morf4l1 Kdm5b MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 21448134 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact)|(intact)|(intact)|(biogrid) BIOGRID_319949|UniProt_173559|UniProt_173557|UniProt_173558|UniProt_173556|BIOGRID_319950 prey|bait|prey|bait|prey|bait bait|prey|bait|prey|bait|prey Hdac1 Kdm5b MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21448134 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(biogrid)|(biogrid) UniProt_173552|UniProt_173551|UniProt_173550|BIOGRID_319951|BIOGRID_319954 prey|bait|prey|prey|bait prey|prey|bait|bait|prey

PPI - HINT Gene A Gene B PMID Method Quality HDAC1 KDM5B 21448134,21448134 0004,0006 LC MORF4L1 KDM5B 21448134,21448134 0004,0006 LC SIN3A KDM5B 21448134,21448134 0004,0006 LC KDM5B TEX189 21448134 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q80Y84 P68432 KDM5B P68432 0.033 17320160 Q80Y84 Q60520 KDM5B SIN3A 0.61 21448134 Q80Y84 O09106 KDM5B HDAC1 0.61 21448134 Q80Y84 P60762 KDM5B MORF4L1 0.61 21448134