PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Grap2 Csf1r 9857184 mint,intact exp Grap2 Grap2 i2d exp Grap2 Lcp2 15668918 innatedb,i2d exp, ortho Grap2 Shc1 9872323 biogrid,i2d exp, ortho Grap2 Kit 9872323 biogrid,i2d exp, ortho Grap2 Stambp i2d exp, ortho Grap2 Usp8 12176364 i2d,mint,intact exp, ortho Grap2 Gab1 12176364 i2d,mint,intact exp, ortho Grap2 Map4k1 15100220 biogrid,i2d,mint,intact exp, ortho Grap2 Gab2 12176364 mint,intact exp, ortho Grap2 Ptpn23 19523899 dip exp, ortho Grap2 Blnk 12176364,15102471 i2d,mint,intact exp, ortho Fyb Grap2 12176364 i2d,mint,intact exp, ortho Grap2 Anapc5 ortho Grap2 Cbl ortho Grap2 Sos1 ortho Grap2 Erbb2 ortho Grap2 Ccndbp1 ortho Grap2 Anapc1 ortho Grap2 Grb2 ortho Grap2 Nagk ortho Grap2 Lck ortho Grap2 Rbpms ortho Grap2 Gab3 ortho Grap2 Asap1 ortho Grap2 Ksr1 ortho Grap2 Cblb ortho Grap2 Pld1 ortho Grap2 Khdrbs1 ortho Grap2 Gfap ortho Grap2 Abl1 ortho Grap2 Zscan21 ortho Grap2 Egfr ortho Protein Cnksr1 Grap2 ortho Grap2 Rin3 ortho Grap2 Spry2 ortho Grap2 Anapc2 ortho Grap2 Tnip1 ortho Grap2 Gnb2l1 ortho Grap2 Prph2 ortho Grap2 Cd28 ortho Grap2 Snx18 ortho Grap2 Lax1 ortho Grap2 Faslg ortho Grap2 Grap ortho Grap2 Dnm2 ortho Grap2 Hnrnpk ortho Grap2 Ywhae ortho Lat Grap2 ortho Grap2 Ar ortho Grap2 Anapc7 ortho Grap2 Alb ortho Grap2 Cdc23 ortho Grap2 Zbtb7b ortho Grap2 Garem ortho Grap2 Syk ortho Grap2 Anapc16 ortho Grap2 Trim68 ortho Cdc27 Grap2 ortho Grap2 Crkl ortho Ifnar2 Grap2 ortho Grap2 Shb ortho Grap2 Itch ortho Grap2 Bend5 ortho Grap2 Sos2 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O89100 - 12773374 - X 2 P70218 O89100 - 10903746 - X 2 O89100 - 15029250 - X 2 Q9QYY0 O89100 - 12176364 - X 2 O89100 Q9QUN3 - 12176364 - X 2 O89100 - 12176364 - X 2 O89100 - 9872323 - X 2 Q60787 O89100 - 12176364 - X 2 O35601 O89100 - 12176364 - X 2 Q80U87 O89100 - 12176364 - X 2 O89100 O89100 - 15029250 - X 2 O89100 O89100 - 15029250 - X 2 P98083-2 O89100 - 9872323 - X 2 P70218 O89100 unspecified method 15100220 direct interaction X 2 Q07889 O89100 pull down 9872323 direct interaction X 2 O89100 P29353-5 biochemical 9872323 association X 2 O89100 P29353-5 pull down 9872323 direct interaction X 2 O89100 Q07666 pull down 9872323 direct interaction X 2 O89100 P05532 affinity chromatography technology 9872323 physical association X 2 P22681 O89100 pull down 9872323 direct interaction X 2 O89100 affinity chromatography technology 9872323 physical association X 2 O89100 Q59FK4 pull down 9872323 direct interaction X 2 P00533 O89100 affinity chromatography technology 9872323 physical association X 2 O89100 pull down 19523899 - C 7 Q9Y5K6 O89100 pull down 19523899 physical association X 2 Q6PB44 O89100 x-ray crystallography 19523899 direct interaction X 2 Q6PB44 O89100 isothermal titration calorimetry 19523899 direct interaction X 2 Q6PB44 O89100 peptide array 19523899 direct interaction X 2 P50570 O89100 pull down 19523899 physical association X 2 P22681 O89100 pull down 19523899 physical association X 2 Q13094 O89100 pull down 19523899 physical association X 2 Q9H3S7 O89100 isothermal titration calorimetry 19523899 direct interaction X 2 Q9H3S7 O89100 pull down 19523899 direct interaction X 2 Q9H3S7 O89100 peptide array 19523899 direct interaction X 2 A0A024R5S4 O89100 pull down 19523899 physical association X 2 P29353 O89100 pull down 9872323 association X 2 P29353 O89100 pull down 9872323 association X 2 Q9Z1S8 O89100 lambda phage display 12176364 physical association X 2 P70218 O89100 isothermal titration calorimetry 15100220 direct interaction X 2 P70218 O89100 x-ray crystallography 15100220 direct interaction X 2 Q9QYY0 O89100 filter binding 12176364 direct interaction X 2 O89100 Q9QUN3 lambda phage display 12176364 physical association X 2 O89100 Q9QUN3 filter binding 12176364 direct interaction X 2 O89100 A0A024QZD6 x-ray crystallography 15029250 association X 2 O89100 A0A024QZD6 x-ray crystallography 15029250 association X 2 O89100 Q9QUN3 two hybrid 15102471 physical association X 2 O89100 Q9QUN3 two hybrid 15102471 physical association X 2 O95630 O89100 isothermal titration calorimetry 12773374 direct interaction X 2 Q8WWW8 O89100 isothermal titration calorimetry 12773374 direct interaction X 2 Q8WV28 O89100 pull down 12176364 physical association X 2 Q8WV28 O89100 isothermal titration calorimetry 12773374 direct interaction X 2 P09581 O89100 two hybrid 9857184 physical association X 2 P09581 O89100 pull down 9857184 association X 2 O35601 O89100 pull down 12176364 direct interaction X 2 O35601 O89100 coimmunoprecipitation 12176364 physical association X 2 O35601 O89100 peptide array 12176364 direct interaction X 2 Q13094 O89100 isothermal titration calorimetry 12773374 direct interaction X 2 Q13094 O89100 isothermal titration calorimetry 12773374 direct interaction X 2 Q13094 O89100 mass spectrometry studies of complexes 12773374 physical association X 2 Q13094 O89100 x-ray crystallography 16511262 direct interaction X 2 Q13094 O89100 x-ray crystallography 17010654 direct interaction X 2 Q13094 O89100 molecular sieving 17010654 direct interaction X 2 Q13480 O89100 isothermal titration calorimetry 12773374 direct interaction X 2 Q80U87 O89100 lambda phage display 12176364 physical association X 2 Q80U87 O89100 lambda phage display 12176364 physical association X 2 Q80U87 O89100 filter binding 12176364 direct interaction X 2 Q80U87 O89100 filter binding 12176364 direct interaction X 2 Q9UQC2 O89100 pull down 12176364 physical association X 2 Q9H3S7 O89100 isothermal titration calorimetry 19523899 direct interaction X 2 Q9H3S7 O89100 peptide array 19523899 direct interaction X 2 Q92918 O89100 isothermal titration calorimetry 15100220 direct interaction X 2 A0A024R5S4 O89100 filter binding 12176364 direct interaction X 2 A0A024R5S4 O89100 pull down 12176364 physical association X 2 A0A024R5S4 O89100 isothermal titration calorimetry 12773374 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Grap2 Gab1 MI:0049(filter binding)|MI:0096(pull down)|MI:0049(filter binding) 12176364 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(intact) UniProt_71082|MINT_61718|UniProt_163556 bait|bait|bait prey|prey|prey Grap2 Gab2 MI:0049(filter binding)|MI:0096(pull down) 12176364 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_163554|MINT_61713 prey|prey bait|bait Grap2 Blnk MI:0049(filter binding)|MI:0049(filter binding)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0049(filter binding)|MI:0096(pull down) 12176364,15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|MI:0471(mint)|(intact)|(intact)|(intact)|MI:0471(mint) UniProt_71084|UniProt_163553|MINT_61723|UniProt_164927|UniProt_164926|UniProt_163558|MINT_61712 bait|prey|bait|prey|prey|bait|prey prey|bait|prey|bait|bait|prey|bait Grap2 Csf1r MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 9857184 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0914(association) MI:0471(mint)|MI:0471(mint)|(intact)|(intact) MINT_80032|MINT_80031|UniProt_177358|UniProt_177359 unspecified role|unspecified role|unspecified role|unspecified role unspecified role|unspecified role|unspecified role|unspecified role Grap2 Ptpn23 MI:0096(pull down) 19523899 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) MI:0465(dip) DIP_709 - - Fyb Grap2 MI:0049(filter binding)|MI:0096(pull down)|MI:0049(filter binding)|MI:0049(filter binding)|MI:0049(filter binding)|MI:0096(pull down)|MI:0096(pull down) 12176364 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(intact)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint) UniProt_163564|MINT_59972|UniProt_163565|UniProt_163561|UniProt_71087|MINT_61719|MINT_61733 prey|bait|bait|bait|bait|prey|bait bait|prey|prey|prey|prey|bait|prey Grap2 Abl1 MI:0401(biochemical) 9872323 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_311442 bait prey Grap2 Map4k1 MI:0065(isothermal titration calorimetry)|MI:0065(isothermal titration calorimetry)|MI:0065(isothermal titration calorimetry)|MI:0065(isothermal titration calorimetry)|MI:0065(isothermal titration calorimetry)|MI:0686(unspecified method) 15100220 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|(biogrid) UniProt_77647|UniProt_163831|UniProt_163830|MINT_60123|MINT_60122|BIOGRID_324407 unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|bait unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|prey Grap2 Kit MI:0401(biochemical) 9872323 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_311450 bait prey Grap2 Usp8 MI:0096(pull down)|MI:0049(filter binding)|MI:0096(pull down)|MI:0096(pull down)|MI:0049(filter binding)|MI:0049(filter binding)|MI:0049(filter binding)|MI:0096(pull down)|MI:0049(filter binding)|MI:0049(filter binding) 12176364 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|MI:0471(mint)|(intact)|(intact) MINT_61722|UniProt_71085|MINT_61721|MINT_61711|UniProt_163552|UniProt_71083|UniProt_163551|MINT_60105|UniProt_163559|UniProt_163557 bait|bait|bait|prey|prey|bait|prey|prey|bait|bait prey|prey|prey|bait|bait|prey|bait|bait|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality FYB GRAP2 12176364,12176364,12176364,12176364 0096,0045,0019,0081 LC GRAP2 GRAP2 12773374,15029250,19523899,17010654 0114,0114,0114,0114 LC GRAP2 CSF1R 9857184,9857184 0096,0018 LC GRAP2 MAP4K1 15100220,15100220 0114,0065 LC GRAP2 LCP2 12176364,12176364,12176364,12176364,12773374 0019,0053,0047,0405,0114 LC GRAP2 PTPN23 19523899,19523899,19523899 0065,0081,0114 LC GRAP2 USP8 12176364,12176364,12176364,12176364,12176364 0047,0045,0004,0049,0066 LC GRAP2 STAMBP 12176364,12176364 0047,0045 LC GRAP2 BLNK 12176364,12176364,12176364,15102471,12176364,12176364 0004,0049,0045,0018,0047,0066 LC GRAP2 GAB1 12176364,12176364,12176364 0047,0045,0049 LC GRAP2 GAB2 12176364 0066 LC FYB GRAP2 12176364,12176364,12176364,12176364 0096,0045,0019,0081 LC GRAP2 ABL1 9872323 0004 LC GRAP2 KIT 9872323 0004 LC GRAP2 CSF1R 9857184,9857184 0096,0018 LC GRAP2 SHC1 9872323 0096 LC GRAP2 LCP2 15668918 0007 LC GRAP2 USP8 12176364,12176364,12176364,12176364,12176364 0047,0045,0004,0049,0066 LC GRAP2 BLNK 12176364,12176364,12176364,12176364,12176364 0004,0049,0045,0047,0066 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P22681 O89100 CBL GRAP2 0.454 19523899,9872323 P22682 O89100 CBL GRAP2 0.126 27474268 Q60787 O89100 LCP2 GRAP2 0.236 24584089 O89100 O43561 GRAP2 LAT 0.523 15029250 Q9Z1S8 O89100 GAB2 GRAP2 0.21 12176364 Q9Y5K6 O89100 CD2AP GRAP2 0.21 19523899 O95630 O89100 STAMBP GRAP2 0.309 12773374 P00519 O89100 ABL1 GRAP2 0.309 9872323 P00533 O89100 EGFR GRAP2 0.21 9872323 P05532 O89100 KIT GRAP2 0.21 9872323 P09581 O89100 CSF1R GRAP2 0.454 9857184 P50570 O89100 DNM2 GRAP2 0.21 19523899 P98083 O89100 SHC1 GRAP2 0.309 9872323 Q07666 O89100 KHDRBS1 GRAP2 0.309 9872323 Q07889 O89100 SOS1 GRAP2 0.309 9872323 Q13480 O89100 GAB1 GRAP2 0.309 12773374 Q80U87 O89100 USP8 GRAP2 0.623 12176364 Q9H3S7 O89100 PTPN23 GRAP2 0.74 19523899 P40818 O89100 USP8 GRAP2 0.702 19523899,12773374,12176364 Q8WV28 O89100 BLNK GRAP2 0.454 12176364,12773374 Q6PB44 O89100 PTPN23 GRAP2 0.671 19523899 O89100 O35601 GRAP2 FYB 0.623 12176364 Q13094 O89100 LCP2 GRAP2 0.902 19523899,17010654,12773374,16511262 P29353 O89100 SHC1 GRAP2 0.569 9872323 Q92918 O89100 MAP4K1 GRAP2 0.309 15100220 Q8WWW8 O89100 GAB3 GRAP2 0.309 12773374 Q9UQC2 O89100 GAB2 GRAP2 0.21 12176364 Q9QUN3 O89100 BLNK GRAP2 0.554 12176364,15102471 Q9QYY0 O89100 GAB1 GRAP2 0.309 12176364 P70218 O89100 MAP4K1 GRAP2 0.671 15100220 Q3TTA7 O89100 CBLB GRAP2 0.126 27474268