PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Asb4 Irs4 21955513 biogrid exp G G Hsp90aa1 Asb4 ortho G G G G G G G G Ddb1 Asb4 ortho G G G G G G G G Tubb2a Asb4 ortho G G G G G G G G Id2 Asb4 ortho G G G G G G G G Asb4 Asb4 ortho G G G G G G G G Gps1 Asb4 ortho G G G G G G G G Ube2d1 Asb4 ortho G G G G G G G G Hspb8 Asb4 ortho G G G G G G G Dnajb5 Asb4 ortho G G G G G G G G Rit1 Asb4 ortho G G G G G G G G Cul4a Asb4 ortho G G G G G G G G Cul2 Asb4 ortho G G G G G G G G Hspd1 Asb4 ortho G G G G G G G G Cul5 Asb4 ortho Asb7 Asb4 ortho G Farsa Asb4 ortho G G G G G G G Hspb1 Asb4 ortho G G G G G G G G Stub1 Asb4 ortho G G G G G G G G Dnajb4 Asb4 ortho G G G G G G G G Hif1an Asb4 ortho Tfrc Asb4 ortho G G G G G G G G Tubb4a Asb4 ortho G G G G G Rps27l Asb4 ortho G G G G G G G G Rnf7 Asb4 ortho G G G G G G G G Hsp90ab1 Asb4 ortho G G G G G G G G Tubb3 Asb4 ortho G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9Z0Y7 Q9WV71 affinity chromatography technology 21955513 physical association X 2 Q9Z0Y7 Q9WV71 affinity chromatography technology 21955513 physical association X 2 Q9WV71 Q13098-5 affinity chromatography technology 17276034 physical association X 2 O14654 Q9WV71 affinity chromatography technology 21955513 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Asb4 Irs4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21955513 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_319232|BIOGRID_319233 prey|bait bait|prey

PPI - HINT Gene A Gene B PMID Method Quality ASB4 IRS4 21955513 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9WV71 O14654 ASB4 IRS4 0.21 21955513 Q9Z0Y7 Q9WV71 IRS4 ASB4 0.376 21955513 Q9WV71 Q13098 ASB4 GPS1 0.21 17276034