PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ywhae Pard6b 16615898 intact exp G G G G G G G G G G Cdc42 Pard6b 10934474 intact exp G G G G G G G G G G Llgl2 Pard6b 12725730 innatedb exp, ortho G G G G G G G G G G Prkci Pard6b 12725730 innatedb exp, ortho G G G G G G G G G G Pard3 Pard6b 12725730 innatedb exp, ortho G G G G G G G G G G Llgl1 Pard6b 12725730 innatedb,i2d exp, ortho G G G G G G G G G G Ift22 Pard6b ortho G G G G G G G G G G Pard6b Prosc ortho G G G G G G G G G G Cdca3 Pard6b ortho G G G G G G G Ccnk Pard6b ortho G G Rhoj Pard6b ortho G G G G G G G G G G Rassf8 Pard6b ortho G G G G G G G G P4ha1 Pard6b ortho G G G G G G G G G G Iars2 Pard6b ortho G G G G G G G G G G Ppp1ca Pard6b ortho G G G G G G G G G G Prkd1 Pard6b ortho G G G G G Mrpl55 Pard6b ortho G G G G G G G G G G Agps Pard6b ortho Dr1 Pard6b ortho G G G G G G G G G G Gmcl1 Pard6b ortho G G G G G G G G G G Rhoq Pard6b ortho G G G G G G G G G G Dlgap4 Pard6b ortho G G G G G G G G G G Robo1 Pard6b ortho G G G G Mknk1 Pard6b ortho G G G G G G G G G G Eefsec Pard6b ortho G G G G G G G G G Ywhah Pard6b ortho G G G G G G G G G G Dmbt1 Pard6b ortho G G G G G G Avl9 Pard6b ortho G G G G G G G G G G Prkcg Pard6b ortho Myo10 Pard6b ortho G G G G G G G G G G Robo2 Pard6b ortho Ptpn14 Pard6b ortho Golga2 Pard6b ortho G G G G G G G G G G Lrch3 Pard6b ortho Inpp5b Pard6b ortho G G G G G G G G G G Cep76 Pard6b ortho Ankrd32 Pard6b ortho G G G G G G G G G Npm1 Pard6b ortho G G G G G G G G G G Rbm10 Pard6b ortho Foxm1 Pard6b ortho G G G G Pnma1 Pard6b ortho Psmd5 Pard6b ortho G G G G G G G G G G Tp53bp2 Pard6b ortho Recql5 Pard6b ortho G G G G G G G G G Ywhab Pard6b ortho G G G G G G G G G G Wdr83 Pard6b ortho G G G G G G G G G G Pard6b Pard6a ortho G G G G G G Pard6b Pard6g ortho G G G G G G G G G G Hectd3 Pard6b ortho G G G G G G G G G G Gns Pard6b ortho G G G G G G G G G G Pard3b Pard6b ortho G G G G G G G Clptm1 Pard6b ortho G G G G G G G G G G Rnf170 Pard6b ortho Icam5 Pard6b ortho G Kiaa2013 Pard6b ortho G G G G G G G G G G Eme1 Pard6b ortho Phka1 Pard6b ortho G G G G G G G G G Wwc1 Pard6b ortho G G G G G G G G G G Zzef1 Pard6b ortho Cog8 Pard6b ortho G G G G G G G G G Ubr2 Pard6b ortho G G G G G G G G Vps28 Pard6b ortho G G G G G G G G G G Msantd4 Pard6b ortho G G G G G G G G G G Pard6b Epb41l4b ortho G G G G G G G G G G Rac1 Pard6b ortho G G G G G G G G G G Ptprd Pard6b ortho G G G G G G G G G G Kbtbd6 Pard6b ortho Pard6b Mpp5 ortho G G G G G G G G G G Pard6b Arl10 ortho Pard6b Htra1 ortho G G G G G G G G G G Prkcz Pard6b ortho G G G G G G G G G Ywhaz Pard6b ortho G G G G G G G G G G Golim4 Pard6b ortho G G G G G G G G G G Aggf1 Pard6b ortho G G G G G G G G G G App Pard6b ortho G G G G G G G G G G MCG9018, Protein Kbtbd7 Pard6b ortho Ltn1 Pard6b ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9JK83 anti tag coimmunoprecipitation 10934474 association C 4 Q9JK83 coimmunoprecipitation 11532031 association C 4 Q9JK83 coimmunoprecipitation 11257119 association C 4 Q9JK83 coimmunoprecipitation 11532031 association C 6 Q9JK83 anti bait coimmunoprecipitation 16638806 association C 3 Q9JK83 A0A024RAE4 two hybrid 10934474 physical association X 2 Q9JK83 A0A024RAE4 coimmunoprecipitation 10934474 physical association X 2 Q9JK83 A0A024RAE4 two hybrid 10934474 physical association X 2 Q9JK83 A0A024RAE4 anti tag coimmunoprecipitation 12606577 physical association X 2 Q9JK83 A0A024RAE4 x-ray crystallography 12606577 direct interaction X 2 Q9JK83 A0A024RAE4 fluorescent resonance energy transfer 12606577 direct interaction X 2 Q8TEW0 Q9JK83 coimmunoprecipitation 10934474 physical association X 2 Q8TEW0 Q9JK83 pull down 10934474 physical association X 2 Q12799 Q9JK83 two hybrid 10934474 physical association X 2 Q12799 Q9JK83 two hybrid 10934474 physical association X 2 Q9JK83 coimmunoprecipitation 10934474 association C 4

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9JK83 P60766 PARD6B CDC42 0.21 10934474 Q9JK83 P62259 PARD6B YWHAE 0.081 16615898 Q9JK83 F5GZI3 PARD6B PARD3 {ECO:0000313|ENSEMBL:ENSP00000444429} 0.126 26496610 Q9JK83 Q12799 PARD6B TCP10 0.309 10934474 Q9JK83 Q15334 PARD6B LLGL1 0.236 26496610 Q9JK83 Q13625 PARD6B TP53BP2 0.236 26496610 Q9JK83 Q05513 PARD6B PRKCZ 0.236 26496610 Q9JK83 Q02833 PARD6B RASSF7 0.236 26496610 Q9JK83 P62266 PARD6B RPS23 0.236 26496610 Q9JK83 P61353 PARD6B RPL27 0.236 26496610 Q9JK83 P45880 PARD6B VDAC2 0.236 26496610 Q9JK83 P41743 PARD6B PRKCI 0.236 26496610 Q9JK83 Q8NHQ8 PARD6B RASSF8 0.236 26496610 Q9JK83 Q8IXQ5 PARD6B KLHL7 0.236 26496610 Q9JK83 Q6P1M3 PARD6B LLGL2 0.236 26496610 Q9JK83 Q8TEW0 PARD6B PARD3 0.523 26496610,10934474 Q9JK83 P60953 PARD6B CDC42 0.858 12606577,10934474