PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Socs4 Cul5 19385048 biogrid exp, ortho Tceb1 Socs4 ortho G G G G G Socs4 Socs4 ortho G G G G G Mdfic Socs4 ortho G G G G G Kit Socs4 ortho G G G G Nr4a1 Socs4 ortho G G G G G Socs4 Ppapdc2 ortho L-lactate dehydrogenase Socs4 ortho Frs3 Socs4 ortho G G Socs4 Mpp5 ortho G G G G G Tnk2 Socs4 ortho G G G G G Grb2 Socs4 ortho G G G G G Egfr Socs4 ortho G G Socs4 Lect1 ortho Pik3r3 Socs4 ortho Socs4 Pink1 ortho G G G G G Vwf Socs4 ortho G G G G Socs4 Spry1 ortho G G G G G Socs4 Rbp7 ortho G G G Jak2 Socs4 ortho G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q91ZA6 Q15369-2 biochemical 19385048 association X 2 Q91ZA6 Q15370-2 biochemical 19385048 association X 2 Q91ZA6 Q15370-2 x-ray crystallography 19385048 association X 2 Q91ZA6 Q15369-2 x-ray crystallography 19385048 association X 2 Q91ZA6 Q15369-2 pull down 19385048 direct interaction X 2 Q91ZA6 Q15370-2 pull down 19385048 direct interaction X 2 Q91ZA6 Q9D5V5 pull down 19385048 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B TCEB1 Socs4 MI:0401(biochemical)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0401(biochemical) 19385048 taxid:9606(Homo sapiens) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0407(direct interaction)|MI:0914(association)|MI:0914(association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_319447|BIOGRID_160974|BIOGRID_161006|BIOGRID_319423|BIOGRID_160998|BIOGRID_319455 prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait TCEB2 Socs4 MI:0401(biochemical)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0401(biochemical) 19385048 taxid:9606(Homo sapiens) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0914(association)|MI:0407(direct interaction)|MI:0914(association)|MI:0914(association)|MI:0914(association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_161014|BIOGRID_160990|BIOGRID_319463|BIOGRID_319431|BIOGRID_319439|BIOGRID_160982 prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait Socs4 Cul5 MI:0401(biochemical) 19385048 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_319471 prey bait

PPI - HINT Gene A Gene B PMID Method Quality SOCS4 CUL5 19385048 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q91ZA6 Q15370 SOCS4 TCEB2 0.416 19385048 Q91ZA6 Q15369 SOCS4 TCEB1 0.416 19385048 Q9D5V5 Q91ZA6 CUL5 SOCS4 0.183 19385048