PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Socs3 Smad3 17920684 innatedb exp G G G G G G G G G G G Socs3 Pim1 14764533 innatedb exp G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Crkl 15173187 innatedb exp G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Ido1 19088199 biogrid,dip exp G G G G G G Socs3 Tceb2 18590740,9869640,15601820 innatedb,biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Lmo4 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Nod2 23019338 biogrid exp Socs3 Nck1 15173187 innatedb exp G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Stat3 15070676 innatedb exp G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Lepr 16698021 mint,intact exp, ortho G G G G G G G G G Socs3 Tfdp1 18687693 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Il6st 10829066,16905102,23454976 innatedb,biogrid,mint,intact,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Jak1 23990909 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Acadvl 22093833 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Jak2 15143188,10882725,10545526,23454976 innatedb,biogrid,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Map1s 19027008 mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Insr 15169905 biogrid exp, ortho G G Socs3 Bcl10 15213237 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Cul5 18590740,19385048,15601820 innatedb,biogrid,intact exp, ortho Socs3 Csnk1e 15070676 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G Socs3 Epor 10882725 innatedb exp, ortho G G G G G G G G G G G G Socs3 Ptpn11 12403768 mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Tceb1 18590740,9869640,15601820 innatedb,biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Rnf7 15601820 innatedb,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Rnf31 ortho Socs3 Il2rb ortho G G G G G G Socs2 Socs3 ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Egfr ortho G G G G G G G G G G G G G G G G G Socs3 Nfkb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Ptk2b ortho G G G G G G G G G G G G G G G G G G G G Map3k5 Socs3 ortho G G G G G G G G G G G G G G G G G G G G G G Socs3 Mapk6 ortho G G G G G G G G G G G G G G G G G G G G G G Socs3 Traf6 ortho G G G G G G G G G G G G G G G G G G Socs3 Tbk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Gfra1 ortho G G G G Socs3 Lck ortho G G G G G G G G G G G G G G Socs3 Dab1 ortho G G G G Socs3 Elavl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Gab1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Rel ortho G G G G Socs3 Sh2d2a ortho G G Socs3 Cxcr4 ortho G G G G G G G G G G G Socs3 Csf1r ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Irs2 ortho G G G G G G G G G G G G G G G Socs3 Mapk8ip1 ortho G G G G G G G Socs3 Jak3 ortho G G G G G G G G G G G G G G Socs3 App ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Bik ortho G G G G G G G G G G G Socs3 Mapk11 ortho G G G G Socs3 Igf1r ortho G G G G G G G G G G G G G G G G G G G G G G G Socs3 Yes1 ortho G G G G G G G G G G G G G G G G G G G G Protein Rasa1 Socs3 ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Rpl7a ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Txndc11 ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Ar ortho G G G G G G G G G G G Socs3 Rela ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Kit ortho G G G G G G G G G G G G G G G G G G G G Socs3 Tes ortho G G G G G G G G G G G G G G G G G G G G G G G G Trdn Socs3 ortho G G G G G G G Socs3 Nfkbia ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Ppp3cb ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Hivep1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Abl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Ptk6 ortho G G G Socs3 Pin1 ortho Socs3 Prlr ortho G G G G G G G G G G G G G G Socs3 Nme4 ortho G G G G Socs3 Fgfr2 ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Etv6 ortho G G G G G G G G G G G G G G G Socs3 Cuedc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Vhl ortho G G G G G G G G G G G G G G G G G G G G G Socs3 Il12rb2 ortho G Socs3 Met ortho G G G G G G G G G G G G G G G G G G G G G G G Socs3 Pkm ortho G G G G G G G G G G G G G G G G G G G G G G G Socs3 Axl ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Irs1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Snai1 ortho G G G Socs3 Tfr2 ortho G G G G G G G Socs3 Ptk2 ortho G G G G G G G G G G G G G G G G G G G G G G G Socs3 Csf3r ortho G G G G G G G Socs3 Pdpk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Tnfsf10 ortho G G G G G Socs3 Ghr ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Rbmx ortho G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Nono ortho G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P61969 O35718 - 15677447 - X 2 O35718 - 15677447 - C 5 P62869 O35718 pull down 18590740 direct interaction X 2 P62869 O35718 affinity chromatography technology 9869640 physical association X 2 P62869 O35718 pull down 9869640 direct interaction X 2 O35718 Q9D5V5 pull down 18590740 direct interaction X 2 O35718 pull down 23990909 direct interaction X 2 O35718 Q6PDI9 unspecified method 23454976 direct interaction X 2 O35718 Q15369-2 biochemical 19385048 association X 2 O35718 Q15369-2 x-ray crystallography 19385048 association X 2 O35718 Q15369-2 pull down 19385048 direct interaction X 2 O35718 Q9D5V5 pull down 19385048 direct interaction X 2 P15208 O35718 affinity chromatography technology 15169905 physical association X 2 Q9Z0H7 O35718 affinity chromatography technology 15213237 physical association X 2 P83940 O35718 pull down 18590740 direct interaction X 2 P83940 O35718 affinity chromatography technology 9869640 physical association X 2 P83940 O35718 pull down 9869640 direct interaction X 2 P50544 O35718 affinity chromatography technology 22093833 physical association X 2 O35718 affinity chromatography technology 23019338 physical association X 2 O35718 affinity chromatography technology 23019338 physical association X 2 O35718 G5E852 pull down 23454976 direct interaction X 2 O35718 G5E852 x-ray crystallography 23454976 association X 2 O35718 G5E852 affinity chromatography technology 15143188 physical association X 2 O35718 Q15370-2 biochemical 19385048 association X 2 O35718 Q15370-2 x-ray crystallography 19385048 association X 2 O35718 Q15370-2 pull down 19385048 direct interaction X 2 O35718 P28776 pull down 19088199 direct interaction X 2 O35718 P28776 affinity chromatography technology 19088199 physical association X 2 O35718 Q6PDI9 isothermal titration calorimetry 16905102 direct interaction X 2 O35718 Q6PDI9 x-ray crystallography 16905102 direct interaction X 2 O35718 pull down 23454976 - C 4 O35718 pull down 23454976 - C 4 O35718 x-ray crystallography 23454976 physical association C 3 O35718 molecular sieving 23454976 physical association C 3 O35718 x ray scattering 23454976 physical association C 3 O35718 ion exchange chromatography 23454976 physical association C 3 O35718 P28776 anti tag coimmunoprecipitation 19088199 physical association X 2 O35718 G5E852 pull down 23454976 physical association X 2 O35718 G5E852 pull down 23454976 physical association X 2 O35718 Q8C052 anti bait coimmunoprecipitation 19027008 physical association X 2 O35718 anti bait coimmunoprecipitation 15601820 association C 5 O35718 P35235 pull down 12403768 association X 2 O35718 P35235 surface plasmon resonance 12403768 association X 2 O35718 P48356 two hybrid 16698021 physical association X 2 O35718 Q66K74 anti bait coimmunoprecipitation 19027008 physical association X 2 Q00560 O35718 isothermal titration calorimetry 16905102 direct interaction X 2 Q00560 O35718 isothermal titration calorimetry 16905102 direct interaction X 2 Q00560 O35718 x-ray crystallography 16905102 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Socs3 Tceb2 MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15601820,18590740,9869640 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid) UniProt_164465|BIOGRID_325572|BIOGRID_315427|BIOGRID_315415 bait|bait|bait|bait prey|prey|prey|prey Socs3 Insr MI:0004(affinity chromatography technology) 15169905 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324060 bait prey Socs3 Lepr MI:0018(two hybrid)|MI:0018(two hybrid) 16698021 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_166882|MINT_81479 prey|prey bait|bait Socs3 Tceb1 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 15601820,18590740,9869640 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association) (biogrid)|(biogrid)|(biogrid)|(intact) BIOGRID_325571|BIOGRID_315416|BIOGRID_315428|UniProt_164465 bait|bait|bait|bait prey|prey|prey|prey Socs3 Ido1 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19088199 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(biogrid) DIP_824|BIOGRID_319478|BIOGRID_319479 -|prey|prey -|bait|bait Socs3 Socs3 MI:0096(pull down)|MI:0096(pull down) 19088199 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0465(dip) DIP_826|DIP_823 -|- -|- Socs3 Ptpn11 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 12403768 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (intact)|(intact)|MI:0471(mint)|MI:0471(mint) UniProt_163588|UniProt_163587|MINT_79857|MINT_79856 unspecified role|unspecified role|unspecified role|unspecified role unspecified role|unspecified role|unspecified role|unspecified role Socs3 Nod2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23019338 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_325030|BIOGRID_325031 prey|bait bait|prey Socs3 Map1s MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19027008 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|(intact) MINT_68829|UniProt_97840|UniProt_168985 prey|prey|prey bait|bait|bait Socs3 Cul5 MI:0401(biochemical)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation) 15601820,18590740,19385048 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0914(association) (biogrid)|(biogrid)|(intact) BIOGRID_319470|BIOGRID_325573|UniProt_164465 prey|bait|bait bait|prey|prey Socs3 Bcl10 MI:0004(affinity chromatography technology) 15213237 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322562 prey bait Socs3 Il6st MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography) 16905102 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0465(dip)|(intact)|(intact) MINT_84211|MINT_84212|MINT_84213|UniProt_167564|DIP_316|UniProt_167563|UniProt_167562 neutral component|bait|bait|bait|-|bait|neutral component neutral component|prey|prey|prey|-|prey|neutral component Socs3 Acadvl MI:0018(two hybrid) 22093833 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_318861 prey bait Socs3 Jak2 MI:0004(affinity chromatography technology) 15143188 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315436 prey bait

PPI - HINT Gene A Gene B PMID Method Quality SOCS3 PIM1 14764533,14764533 0007,0423 LC SOCS3 PTPN11 12403768,12403768 0096,0107 LC SOCS3 LEPR 16698021 0018 LC SOCS3 LMO4 15677447 0019 LC SOCS3 TCEB1 18590740,18590740 0096,0114 LC SOCS3 IL6ST 10829066,10829066,16905102,16905102 0107,0004,0065,0114 LC SOCS3 JAK2 23454976,23454976 0096,0114 LC SOCS3 PIM1 14764533,14764533 0007,0423 LC SOCS3 EPOR 10882725 0007 LC SOCS3 INSR 15169905 0004 LC SOCS3 IDO1 19088199,19088199,19088199 0096,0004,0007 LC SOCS3 PTPN11 12403768,12403768 0096,0107 LC SOCS3 STAT4 20620946 0007 LC SOCS3 CRKL 15173187 0007 LC SOCS3 ACADVL 22093833 0004 LC SOCS3 JAK1 23990909 0096 LC SOCS3 STAT6 20620946 0007 LC SOCS3 TCEB2 15601820,9869640,15601820,18590740,9869640,9869640 0006,0096,0007,0096,0004,0007 LC SOCS3 TCEB1 15601820,9869640,15601820,18590740,18590740,9869640 0006,0096,0007,0096,0114,0004 LC SOCS3 IL6ST 10829066,10829066 0107,0004 LC SOCS3 TFDP1 18687693 0007 LC SOCS3 JAK2 10545526,23454976,15143188,10882725,23454976 0007,0096,0004,0007,0114 LC SOCS3 SMAD3 17920684 0007 LC SOCS3 MAP1S 19027008 0006 LC SOCS3 NOD2 23019338 0004 LC SOCS3 CUL5 15601820,15601820,18590740,19385048 0006,0007,0096,0096 LC SOCS3 CSNK1E 15070676 0007 LC SOCS3 RNF7 15601820,15601820 0006,0007 LC SOCS3 BCL10 15213237,15213237 0007,0004 LC