PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Mdm4 Usp7 20697359 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Tp53 19573810,21730132,11953423,20697359 biogrid,intact,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Mdm2 17616658,22666487,19573810,21730132,20697359,25117711 biogrid,intact,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Ubc 20697359 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Ywhag 24190973,21148311 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Cdkn1a 21148311 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Rps20 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Cd160 ortho G G G G G G G Mdm4 Mre11a ortho G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Abl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Tp73 ortho G Mdm4 Lrsam1 ortho Mdm4 Hsp90ab1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Rfwd2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Tp63 ortho G G G G G G G Mdm4 Ppp1cc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Rad54b ortho Mdm4 Smarca2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG19772, Protein Trim55 Mdm4 ortho Mdm4 Atm ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Prkaa1 ortho Mdm4 Ppp1cb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Mnat1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Psmd2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 E2f1 ortho G G G G G Mdm4 Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Psmc5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Ppp1ca ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Mdm4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Mkrn3 ortho Mdm4 Ube2d3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Sfn ortho G G G G G G G G Mdm4 Trim46 ortho G G G G G G G G G G G Mdm4 Rpl37 ortho Mdm4 Rps15 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Smad3 ortho G G G G G G G G G G G G G G G Mdm4 Rb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Capn7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Uncharacterized protein C1orf111 homolog ortho Ep300 Mdm4 ortho Mdm4 Usp22 ortho G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Nbn ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kpna3 Mdm4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Chek1 Mdm4 ortho G G G G G G G G G G G G G G G Mdm4 Smad4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Bcl2 ortho G G G G G G G G G G G G G G G Mdm4 Cdkn2a ortho Mdm4 Arf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Akt1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Ywhah ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 App ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Prkcd ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Ppard ortho Mdm4 Ywhaz ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Ube2d2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Ube2d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Rad50 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Csnk1a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Casp3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Usp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Ywhab ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Chek2 ortho G G G G G G G G G G G G G G G G G G G G Mdm4 Hsp90aa1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Cdk1 ortho G G G G G G G G G G G G G G G G G G G G G Mdm4 Ywhae ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Uba1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Daxx Mdm4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O35618 P23804 pull down 17616658 direct interaction X 2 O35618 P23804 affinity chromatography technology 19573810 physical association X 2 O35618 P0CG50 affinity chromatography technology 20697359 physical association X 2 O35618 P23804 affinity chromatography technology 20697359 physical association X 2 O35618 P23804 affinity chromatography technology 21730132 physical association X 2 O35618 P23804 affinity chromatography technology 22666487 physical association X 2 O35618 affinity chromatography technology 20697359 physical association X 2 Q00987 O35618 enzymatic study 21572037 direct interaction X 2 O35618 P61077-3 pull down 21572037 direct interaction X 2 O35618 P61982 affinity chromatography technology 24190973 physical association X 2 O35618 P62258 pull down 19573810 direct interaction X 2 O35618 P61982 affinity chromatography technology 21148311 physical association X 2 O35618 P04637-7 enzymatic study 21572037 direct interaction X 2 Q549C9 O35618 affinity chromatography technology 19573810 physical association X 2 Q549C9 O35618 affinity chromatography technology 20697359 physical association X 2 Q549C9 O35618 affinity chromatography technology 21730132 physical association X 2 P39689 O35618 affinity chromatography technology 21148311 physical association X 2 K7PPA8 O35618 coimmunoprecipitation 8895579 physical association X 2 O35618 P23804 anti bait coimmunoprecipitation 21730132 physical association X 2 Q549C9 O35618 anti bait coimmunoprecipitation 21730132 physical association X 2 O35618 anti bait coimmunoprecipitation 19573810 physical association C 3 O35618 anti bait coimmunoprecipitation 20697359 physical association C 3 O35618 anti bait coimmunoprecipitation 25117711 association C 3 O35618 pull down 19573810 physical association C 3 O35618 pull down 19573810 physical association C 3 O35618 anti bait coimmunoprecipitation 20697359 physical association C 3 O35618 P23804 anti bait coimmunoprecipitation 20697359 physical association X 2 O35618 P23804 anti bait coimmunoprecipitation 20697359 physical association X 2 Q93009 O35618 anti bait coimmunoprecipitation 15916963 physical association X 2 P23804-2 O35618 anti bait coimmunoprecipitation 20697359 physical association X 2 P23804-2 O35618 anti bait coimmunoprecipitation 20697359 physical association X 2 O35618 anti bait coimmunoprecipitation 15916963 association C 3 O35618 anti bait coimmunoprecipitation 20697359 physical association C 3

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Mdm4 Tp53 MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19573810,20697359,21730132 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(biogrid)|(biogrid) UniProt_170436|UniProt_108995|UniProt_173075|BIOGRID_318822|BIOGRID_319620 bait|prey|prey|prey|bait prey|bait|bait|bait|prey Mdm4 Usp7 MI:0004(affinity chromatography technology) 20697359 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_318826 prey bait Mdm4 Cdkn1a MI:0004(affinity chromatography technology) 21148311 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_318868 bait prey Mdm4 Ubc MI:0004(affinity chromatography technology) 20697359 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_318821 prey bait Mdm4 Mdm2 MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0428(imaging technique)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 17616658,19573810,20697359,21730132,22666487 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(intact)|(biogrid)|(intact)|(intact)|(intact) UniProt_170436|UniProt_108995|UniProt_173075|BIOGRID_320353|BIOGRID_319619|UniProt_173073|BIOGRID_318824|UniProt_173080|UniProt_173079|BIOGRID_322449|UniProt_173074|UniProt_108994|UniProt_108993 bait|prey|prey|prey|bait|bait|bait|bait|bait|prey|bait|bait|bait prey|null|null|bait|prey|null|prey|null|null|bait|null|null|null Mdm4 Ywhag MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21148311,24190973 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_333089|BIOGRID_318869 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality MDM4 TP53 11953423,25981963,20697359,20697359,21730132,21730132,19573810,19573810 0004,0004,0004,0006,0006,0004,0006,0004 LC MDM4 UBC 20697359 0004 LC MDM4 MDM2 17616658,25117711,20697359,20697359,25981963,21730132,22666487,21730132,19573810,19573810 0096,0006,0004,0006,0004,0006,0004,0004,0006,0004 LC MDM4 CDKN1A 21148311 0004 LC MDM4 YWHAG 24190973,21148311 0004,0004 LC MDM4 USP7 20697359 0004 LC