PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ep300 Epc1 19359245 biogrid exp Ep300 Rarb 21722948 biogrid exp Ep300 Il9 26365427 intact exp Ep300 Bcl11b 16809611 biogrid exp Ep300 Hist3h2a 16704373 biogrid exp P Ep300 Il17f 23021777,21278738 innatedb,intact exp Ep300 Tle6 20211142 biogrid exp Ep300 Rarg 21722948 biogrid exp Ep300 Il12rb1 23021777 intact exp Ep300 Pou5f1 22036565 intact exp Ep300 Xbp1 20660350 innatedb exp Ep300 Pitx2 12464179 biogrid exp Ep300 Perp 21057544 intact exp Ep300 Mecp2 22677942 biogrid exp P Ep300 Rbp1 21722948 intact exp P Ep300 Il1r1 23021777 intact exp Ep300 Il23r 21871655 intact exp Ep300 Myocd 15601857 biogrid exp Ep300 Lefty1 22036565 intact exp Ep300 Crabp2 21722948 intact exp Ep300 Il17a 23021777,21871655,21278738 innatedb,intact exp Ep300 Il17ra 21871655 intact exp Ep300 Lefty2 22036565 intact exp Ep300 Stat2 10464260 innatedb exp, ortho P Ep300 Sele 19103749 intact exp, ortho Ep300 Foxo3 18268343,22094330 biogrid exp, ortho Ep300 Nr1h3 25962847 intact exp, ortho Ep300 Pik3r1 21057544 biogrid,i2d,intact exp, ortho P Ep300 Runx1 14752096 biogrid exp, ortho Ep300 Myod1 9659901,14749395 biogrid exp, ortho Ep300 Kat2b 9659901,9742083,20211142 biogrid,i2d exp, ortho Ep300 Vegfa 20609350 intact exp, ortho Ep300 Stat6 26365427 intact exp, ortho P Ep300 Ncoa3 15145939 innatedb exp, ortho Ep300 Foxp3 22579476 biogrid exp, ortho Ep300 Nupr1 19723804 biogrid exp, ortho Ep300 Cebpb 15878863 biogrid exp, ortho Ep300 Ifnar1 17923090 innatedb exp, ortho Ep300 Nr1h4 19883617 biogrid exp, ortho Ep300 Gata4 11481322 biogrid exp, ortho P Ep300 Ncoa1 8855229 biogrid exp, ortho Ep300 Rara 21722948 biogrid exp, ortho Ep300 Usf1 21680747 biogrid exp, ortho P Ep300 Tcf12 15189737 biogrid exp, ortho Ep300 Hes6 20609350 intact exp, ortho Ep300 Spi1 16702405,17562868 biogrid exp, ortho Ep300 Cebpa 22086955 biogrid exp, ortho Ep300 Sirt1 21454709 biogrid exp, ortho Ep300 Zbtb7b 20810990 biogrid exp, ortho Ep300 Mdm2 11715018 innatedb exp, ortho Ep300 Nfatc1 15117818 biogrid exp, ortho P Ep300 Ubtf 16582105 biogrid exp, ortho P Ep300 Kat2a 9742083 biogrid,i2d exp, ortho Ep300 Irf3 20453844 innatedb exp, ortho P Ep300 Smad7 22036565 intact exp, ortho Ep300 Etv4 14976201 biogrid exp, ortho Ep300 Chd4 15189737 biogrid exp, ortho P Ep300 Hif1a 18268343 biogrid exp, ortho Ep300 Ifnar2 17923090 innatedb exp, ortho Ep300 Notch1 i2d exp, ortho Ep300 Kdm3a 20609350 intact exp, ortho P Ep300 Ctnnb1 11050151 innatedb exp, ortho P Ep300 Yy1 17220375 biogrid exp, ortho P Ep300 Snip1 15378006 intact exp, ortho Ep300 Tp53 10706102,22666487,21057544,25117711 biogrid,i2d,intact exp, ortho Ep300 Creb1 17525731 biogrid exp, ortho P Ep300 Atf2 10327051 biogrid exp, ortho Ep300 Rela 12672795,20211142,24019758,23999430 biogrid,i2d,dip exp, ortho P Ep300 Hoxb4 ortho Ep300 Hoxb1 ortho Ep300 Kdm1a ortho P Ep300 Zbtb48 ortho Ep300 Ahr ortho Ep300 Kctd5 ortho Ep300 G protein pathway suppressor 2, MCG22494, isoform CRA_b, Protein Gps2 ortho Ep300 Nr3c1 ortho P Ep300 Dync1i1 ortho P Ep300 Tcf7l2 ortho Ep300 Rps6kb2 ortho P Ep300 Ube2i ortho P Ep300 Tcf3 ortho Ep300 Cebpd ortho Ep300 Mef2d ortho Ep300 Rps6ka5 ortho Ep300 Mitf ortho Ep300 Srf ortho Ep300 Pparg ortho Ep300 Maged1 ortho P Ep300 Hist2h2ab ortho P Ep300 Prdx4 ortho P Ep300 Rel ortho Ep300 Hipk2 ortho Ep300 Sirt2 ortho P Ep300 Atg7 ortho P Ep300 AL022818 ortho P Ep300 Gtf3c1 ortho P Ep300 Fbxo25 ortho Ep300 Neurod1 ortho Ep300 Gaa ortho P Ep300 Pla2g4a ortho Ep300 Bmi1 ortho Ep300 Sertad1 ortho Ep300 Sepp1 ortho P Ep300 Arntl ortho Ep300 Cops6 ortho P Ep300 Morf4l1 ortho P Ep300 Nabp2 ortho Ep300 Mef2a ortho Ep300 Mapk14 ortho P Ep300 Pck2 ortho Ep300 Polb ortho P Ep300 Sub1 ortho P Ep300 Mcm2 ortho P Ep300 Skp2 ortho Ep300 Nfkb1 ortho P Ep300 Igbp1 ortho P Ep300 Mre11a ortho Ep300 Khdrbs1 ortho P Ep300 Orc2 ortho Ep300 Hnrnpu ortho P Ep300 Rbbp5 ortho Ep300 Spib ortho Ep300 Pou3f2 ortho Ep300 E2f5 ortho Ep300 Uncharacterized protein C3orf62 homolog ortho Ep300 Mybl2 ortho Ep300 Yap1 ortho P Ep300 Rps26 ortho P Ep300 Ilf3 ortho P Ep300 Ascc1 ortho P Ep300 Tfe3 ortho Ep300 Prkca ortho P Ep300 Ruvbl2 ortho P Ep300 Ddx24 ortho Ep300 Mapt ortho P Ep300 Crebbp ortho P Ep300 Tnk2 ortho Ep300 Bmf ortho Ep300 Zbtb49 ortho Ep300 Mtf1 ortho Ep300 Thra ortho Ep300 Cited4 ortho Ep300 Prox1 ortho Ep300 Vhl ortho Ep300 Etv1 ortho Ep300 Ncoa2 ortho Ep300 Vps18 ortho P Ep300 Hist2h2ac ortho P Ep300 Ccnb2 ortho Ep300 Ddb2 ortho Ep300 Tbp ortho Ep300 Myc ortho Ep300 Tnf ortho Ep300 Srebf1 ortho Ep300 Calcoco1 ortho Ep300 Tcf4 ortho Ep300 Dna2 ortho P Ep300 Plscr1 ortho Ep300 Abl1 ortho Ep300 Cdx2 ortho Ep300 Strap ortho P Ep300 Mapk8 ortho P Ep300 Btrc ortho Protein Prdm2 Ep300 ortho Ep300 E2f4 ortho Ep300 Satb1 ortho Ep300 Gata2 ortho Ep300 Dyrk1b ortho Ep300 Maf ortho Ep300 Hdac1 ortho P Ep300 MCG3834, Protein Zbtb16, Zinc finger and BTB domain containing 16 ortho Ep300 Jdp2 ortho Ep300 Klf15 ortho Ep300 Npas2 ortho Ep300 Mybbp1a ortho P Ep300 Terf1 ortho Ep300 Klf4 ortho Ep300 Usf2 ortho P Ep300 Ing2 ortho Ep300 Smarca4 ortho Ep300 Ing4 ortho Ep300 Tgs1 ortho Ep300 Pcna ortho P Ep300 Plk1 ortho Ep300 Map9 ortho Ep300 Tp73 ortho Ep300 Eid1 ortho Ep300 Tp63 ortho Ep300 Fbxl5 ortho Ep300 Nbn ortho Ep300 Lef1 ortho Ep300 Nr2f2 ortho Ep300 Gtf3c5 ortho P Ep300 Traf2 ortho Ep300 Gtf2b ortho P Ep300 Mapk1 ortho P Ep300 Fhl1 ortho P Ep300 Tff1 ortho Ep300 Senp3 ortho Ep300 Irf5 ortho Ep300 Anapc2 ortho P Ep300 Cd2 ortho Ep300 Brd7 ortho Ep300 Ep300 ortho P Ep300 Ube2d1 ortho Ep300 Ppargc1a ortho Ep300 Pml ortho P Ep300 Hoxb7 ortho Ep300 Anapc7 ortho P Ep300 Cfh ortho P Ep300 Pak2 ortho P Ep300 Myb ortho Ep300 Tacc2 ortho P Ep300 Msh6 ortho P Ep300 Xpa ortho Ep300 Pax8 ortho Ep300 Gabpa ortho P Ep300 Cited1 ortho Ep300 Smad2 ortho P Ep300 Gata6 ortho Ep300 Cdkn1a ortho Ep300 Hnf1a ortho P Ep300 Ing5 ortho Ep300 Acsm5 ortho Ep300 Hmgn1 ortho Ep300 Mdc1 ortho P Ep300 Cdc16 ortho P Ep300 Klf5 ortho Ep300 Banp ortho Ep300 Mcm4 ortho P Ep300 Ppp1r13l ortho Ep300 Map2k1 ortho P Ep300 Noxa1 ortho Ep300 Trip4 ortho P Ep300 Ss18 ortho P Ep300 Cltc ortho P Ep300 Elf3 ortho Ep300 Med23 ortho P Ep300 Fgfr1 ortho Ep300 Ldha ortho P Ep300 Ss18l1 ortho Ep300 Esr1 ortho Ep300 Tcl1a ortho Ep300 Kat5 ortho Ep300 Ncor2 ortho P Ep300 Zbtb33 ortho Ep300 Hand2 ortho Ep300 Taf1b ortho Ep300 Gpbp1 ortho Ep300 Cdh1 ortho Ep300 Fn1 ortho P Ep300 Crtc2 ortho Ep300 Sav1 ortho Ep300 Bag6 ortho P Ep300 Chuk ortho Ep300 Mef2c ortho Ep300 Maml1 ortho Ep300 Commd1 ortho P Ep300 Sp1 ortho P Ep300 Actb ortho P Ep300 Hoxb3 ortho Ep300 Krt18 ortho P Ep300 Ppp1r13b ortho P Ep300 Terf2 ortho Ep300 Epas1 ortho Ep300 Ripk1 ortho P Ep300 Nup98 ortho Ep300 Grip1 ortho Ep300 Epo ortho Ep300 Ing1 ortho Ep300 Protein Herc1 ortho P Ep300 Mcm3 ortho P Ep300 Dao ortho Ep300 Rpl27 ortho P Ep300 Protein Mn1 ortho Ep300 Hdac2 ortho Ep300 Stat5b ortho P Ep300 Nap1l4 ortho P Ep300 Hps6 ortho Ep300 Akt1 ortho P Ep300 Gtf3c2 ortho Ep300 Ash2l ortho P Ep300 Hbp1 ortho Ep300 Ets2 ortho Ep300 Hnrnpul1 ortho P Ep300 Smad1 ortho P Ep300 Tnip2 ortho Ep300 Cbx8 ortho Ep300 Nanog ortho Ep300 Protein N4bp2 ortho P Ep300 Cobl ortho Ep300 Vdr ortho Ep300 Pax6 ortho Ep300 Bub1b ortho Ep300 Smad5 ortho Ep300 Eef2 ortho P Ep300 Npm1 ortho P Ep300 Atf5 ortho Ep300 Bcl3 ortho Ep300 Irf1 ortho Ep300 Kpna2 ortho P Ep300 Ybx1 ortho P Ep300 Pin1 ortho P Ep300 Tbx21 ortho Ep300 Ccna2 ortho Ep300 Ctbp2 ortho P Ep300 Ascl2 ortho Ep300 Cited2 ortho Ep300 Klf8 ortho Ep300 Fos ortho Ep300 Sox4 ortho Ep300 Tinagl1 ortho Ep300 Nutm1 ortho Ep300 Cdk2 ortho P Ep300 Klf2 ortho Ep300 Itih3 ortho P Ep300 Npy5r ortho Ep300 Hoxb6 ortho Ep300 Zeb1 ortho Ep300 Aurkb ortho Ep300 Pold2 ortho P Ep300 Map3k1 ortho Ep300 Rad50 ortho P Ep300 Brms1 ortho Ep300 Stat3 ortho P Ep300 Eef1a1 ortho P Ep300 Mpg ortho Ep300 Nr3c2 ortho Ep300 Prmt1 ortho P Ep300 E2f1 ortho Ep300 Prkcb ortho P Ep300 Nfatc2 ortho Ep300 Pdhx ortho P Ep300 Ddx5 ortho P Ep300 Klf13 ortho Ep300 Hdac3 ortho P Ep300 Mcm5 ortho P Ep300 Nfyb ortho Ep300 Trerf1 ortho Ep300 Cttn ortho P Ep300 Tal1 ortho Ep300 Sumo2 ortho P Ep300 Crtc1 ortho Ep300 Ncor1 ortho P Ep300 Ptgs2 ortho Ep300 Fosl1 ortho Ep300 Mdm4 ortho Ep300 Ercc8 ortho Ep300 Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4a, Hist4h4 ortho P Ep300 Cdt1 ortho Ep300 Smad3 ortho Ep300 Wdr59 ortho P Ep300 Atxn3 ortho P Ep300 Ppara ortho Ep300 Bcl6 ortho Ep300 Tsnax ortho P Ep300 Pgr ortho Ep300 Cebpg ortho Ep300 Ets1 ortho Ep300 Prkaa1 ortho P Ep300 Dek ortho P Ep300 Immt ortho P Ep300 Lcp2 ortho Ep300 Rb1 ortho Ep300 Fosl2 ortho Ep300 Dido1 ortho P Ep300 Cd44 ortho Ep300 Protein Taf15, TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor ortho P Ep300 S100a8 ortho Ep300 Mapre1 ortho P Ep300 Ran ortho P Ep300 Ddit3 ortho Ep300 Polr2a ortho Ep300 Tsg101 ortho P Ep300 Ubqln1 ortho P Ep300 Junb ortho Ep300 Smad4 ortho P Ep300 Neil2 ortho Ep300 Foxo1 ortho Ep300 Atf4 ortho Ep300 Klf11 ortho Ep300 Msto1 ortho Ep300 Hist1h2ab, Hist1h2ac, Hist1h2ad, Hist1h2ae, Hist1h2ag, Hist1h2ai, Hist1h2an, Hist1h2ao ortho P Ep300 Dyrk1a ortho P Ep300 Pelp1 ortho P Ep300 Ilf2 ortho P Ep300 Ddx17 ortho P Ep300 Dtx1 ortho Ep300 Irf2 ortho Ep300 Fosb ortho Ep300 Pkm ortho P Ep300 Ascl1 ortho Ep300 Parp1 ortho P Ep300 Mcm3ap ortho Ep300 Prdm6 ortho Ep300 Rps6ka3 ortho P Ep300 Nedd1 ortho Ep300 Crx ortho Ep300 Stat1 ortho P Ep300 Hoxb2 ortho Ep300 Hspa5 ortho P Ep300 Cnot4 ortho Ep300 Stat5a ortho P Ep300 Jmy ortho Ep300 Tp53bp2 ortho P Ep300 Sox9 ortho Ep300 Carm1 ortho P Ep300 Cask ortho P Ep300 Tp53bp1 ortho P Ep300 Bcas2 ortho P Ep300 Set ortho P Ep300 Nr4a1 ortho Ep300 Pax5 ortho Ep300 App ortho P Ep300 Jund ortho Ep300 Smarca2 ortho P Ep300 Ercc5 ortho Ep300 Protein Magea4 ortho Ep300 Tgfb1i1 ortho Ep300 Plg ortho P Ep300 Suv39h1 ortho Ep300 Cxxc1 ortho Ep300 Nfya ortho Ep300 Ccnt1 ortho Ep300 Ctbp1 ortho P Ep300 Clock ortho Ep300 Acta1 ortho P Ep300 Wdr5 ortho P Ep300 Rxra ortho P Ep300 Rbm14 ortho P Ep300 Xrcc6 ortho Ep300 Recql4 ortho Ep300 Hoxa10 ortho Ep300 Ppard ortho Ep300 Fbxw2 ortho Ep300 Fbxw8 ortho Ep300 Mgmt ortho P Ep300 Gorasp1 ortho P Ep300 Ccne1 ortho Ep300 Greb1 ortho Ep300 Pck1 ortho P Ep300 Rad23a ortho P Ep300 Ubc ortho P Ep300 Atxn7 ortho Ep300 Hdac6 ortho P Ep300 Znf148 ortho P Ep300 Rps6kb1 ortho P Ep300 Ppp2ca ortho P Ep300 Ctf1 ortho Ep300 Prkdc ortho P Ep300 Klf1 ortho Ep300 Pias3 ortho Ep300 Kmt2d ortho P Ep300 Zbtb17 ortho Ep300 Dbp ortho Ep300 Rere ortho Ep300 Runx2 ortho Ep300 Pou2f2 ortho Ep300 Fbxo3 ortho Ep300 Atr ortho P Ep300 Smarcd1 ortho Ep300 Grb2 ortho P Ep300 Runx3 ortho Ep300 Thpo ortho Ep300 Ccnd1 ortho Ep300 Esr2 ortho Ep300 Wdr82 ortho P Ep300 Map3k5 ortho P Ep300 Prkcd ortho P Ep300 Sp3 ortho Ep300 Gata5 ortho Ep300 Egr1 ortho Ep300 Zac1 ortho Ep300 Snai1 ortho Ep300 Sumo3 ortho P Ep300 Pcbd1 ortho P Ep300 Hist1h2bb ortho P Ep300 Mta1 ortho Ep300 Brca1 ortho Ep300 Srebf2 ortho Ep300 Serpina5 ortho Ep300 Nr1i3 ortho Ep300 Twist1 ortho Ep300 Nfkbia ortho P Ep300 Fhl2 ortho P Ep300 Zfpm2 ortho Ep300 Hoxd10 ortho Ep300 Cdc20 ortho Cad Ep300 ortho P Ep300 Tfap2a ortho Ep300 Olig2 ortho Ep300 Jun ortho Ep300 Golga2 ortho P Ep300 Hist1h1d ortho P Ep300 Alx1 ortho Ep300 Cdk1 ortho Ep300 Ddb1 ortho P Ep300 Acta2 ortho P Ep300 Sphk1 ortho Ep300 Gopc ortho Ep300 Anxa2 ortho P Ep300 Zc3h12a ortho Ep300 Ar ortho Ep300 Fen1 ortho P Ep300 Arnt ortho Ep300 Irf7 ortho P Ep300 Snw1 ortho P Ep300 Emb ortho P Ep300 Kat6a ortho Ep300 Elk1 ortho Ep300 Nap1l1 ortho P Ep300 Decr2 ortho P Ep300 Tgfbr1 ortho Ep300 Setd2 ortho Ep300 Hoxb9 ortho Ep300 Hoxd4 ortho Ep300 Tada3 ortho Ep300 Zbtb8a ortho Ep300 Rora ortho Ep300 Apex1 ortho P Ep300 Ttc5 ortho Ep300 Anapc5 ortho P Ep300 Znf76 ortho Ep300 Eid2 ortho P Ep300 Max ortho P Ep300 Auts2 ortho Ep300 Hist1h3b, Hist1h3c, Hist1h3d, Hist1h3e, Hist1h3f, Hist2h3b, Hist2h3c1, Hist2h3c2 ortho P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants B2RWS6 P26450 anti bait coimmunoprecipitation 21057544 physical association X 2 B2RWS6 Q8BIZ6 anti bait coimmunoprecipitation 15378006 physical association X 2 B2RWS6 P02340 anti bait coimmunoprecipitation 21057544 physical association X 2 B2RWS6 P02340 cross-linking study 25117711 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality EP300 TP53 25117711 0030 LC EP300 ATF2 10327051 0401 LC EP300 UBTF 16582105 0415 LC EP300 RELA 20211142 0018 HT EP300 HIST3H2A 16704373 0415 LC EP300 KAT2B 20211142 0018 HT EP300 NUPR1 19723804,19723804,19723804 0018,0428,0096 LC EP300 TLE6 20211142 0018 HT EP300 MECP2 22677942 0415 LC EP300 NFATC1 15117818 0004 LC EP300 TP53 21057544,10706102,22666487,21057544 0004,0004,0004,0006 LC EP300 UBC 16704373 0004 LC EP300 MYOD1 14749395,9659901 0004,0004 LC EP300 RARA 21722948 0004 LC EP300 ATF2 10327051 0401 LC EP300 SPI1 16702405,17562868 0004,0004 LC EP300 RARG 21722948 0004 LC EP300 RARB 21722948 0004 LC EP300 PIK3R1 21057544,21057544 0004,0006 LC EP300 CEBPB 15878863 0004 LC EP300 ETV4 14976201 0004 LC EP300 STAT6 26365427 0006 LC EP300 CEBPA 22086955 0004 LC EP300 NCOA1 8855229,8855229 0004,0096 LC EP300 PITX2 12464179 0004 LC EP300 YY1 17220375 0004 LC EP300 CREB1 17525731,17525731 0428,0096 LC EP300 NOTCH1 12391150 0004 LC EP300 RUNX1 14752096 0004 LC EP300 RELA 24019758,23999430,12672795 0006,0004,0004 LC EP300 GATA4 11481322,11481322 0004,0096 LC EP300 NR1H4 19883617 0004 LC EP300 USF1 21680747 0004 LC EP300 HIF1A 18268343,18268343 0004,0428 LC EP300 TCF12 15189737 0004 LC EP300 ZBTB7B 20810990 0004 LC EP300 CHD4 15189737 0004 LC EP300 SNIP1 15378006 0006 LC EP300 EPC1 19359245 0004 LC EP300 MYOCD 15601857 0004 LC EP300 SIRT1 21454709 0004 LC EP300 FOXP3 22579476 0004 LC EP300 BCL11B 16809611 0004 LC EP300 KAT2B 9742083,9659901 0096,0004 LC EP300 KAT2A 9742083 0096 LC EP300 NUPR1 19723804,19723804,19723804 0018,0428,0096 LC EP300 FOXO3 22094330,18268343 0004,0428 LC EP300 NR1H3 25962847 0006 LC