PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Stam2 Aldoa 20697350 biogrid,intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Gng12 20697350 biogrid,intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Crk 20697350 biogrid,intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Ubc 16432517 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Usp8 20130268,10982817 biogrid,i2d,mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Hgs 10651905,12972556,20697350 biogrid,i2d,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Cbx5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbf1 Stam2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Ube2d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Egfr ortho GP G G G G G G G G G G G G G G G G G Stam2 Abi2 ortho Stam2 L3mbtl2 ortho Stam2 Krt8 ortho GP G G G G G G G G G G G G G G G G G G G G G Stam2 Itch ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Ube2h ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pld3 Stam2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Arrdc3 ortho Stam2 Actn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Vcp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Ints8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Tsg101 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Ube2d2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Kif15 ortho P Stam2 Tyk2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Xrcc6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Litaf ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Xpo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Phf10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Tp53bp2 ortho P Stam2 Jak3 ortho G G G G G G G G G G G G G G G Stam2 Ofd1 ortho G G G G G G G G G G G G G G G G Stam2 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Ppp1r13b ortho P Stam2 Fanci ortho G G G G G G G G G G G Stam2 Prkce ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Jak2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Sh2d4a ortho P Stam2 Sf3a3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Plekhb2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Fmr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Eps15 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Dazap2 ortho Stam2 Cog7 ortho Stam2 Mcm5 ortho P G G G G G G G G G G G G G G Stam2 Klhl42 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Stambp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Jak1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Lcp2 ortho G G G G G G G G G G G G G G Stam2 Ube2d3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Timm8a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Tmem17 ortho Stam2 Map3k1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Ubqln1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Atxn1 ortho Stam2 Tmem216 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Ptpn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Ccng1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Ptpn23 ortho GP G G G G G G G G G G G G G G G G G G G G G G Stam2 Sec31a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Napa ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Vps37c ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Nudt6 ortho G G G G G G G G G G G G G MCG17975, Protein Zfyve9 Stam2 ortho Stam2 Srp19 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Sirt4 ortho G G G G G G G G G G G G G G G G G G G G Stam2 Stam ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Fam189a2 ortho Stam2 Ogt ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Dcaf8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Xrn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Rin1 ortho G G G G G G G Stam2 Sec13 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q99LI8 O88811 - 10651905 - X 2 Q99LI8 O88811 - 10651905 - X 2 Q80U87 O88811 - 10982817 - X 2 O88811 P63072 x-ray crystallography 16432517 association X 2 O88811 P0CG50 affinity chromatography technology 22081111 physical association X 2 Q64010 O88811 affinity chromatography technology 20697350 physical association X 2 P0CG48 O88811 pull down 12972556 direct interaction X 2 P0CG48 O88811 pull down 12972556 direct interaction X 2 Q3UMA3 O88811 affinity chromatography technology 10651905 physical association X 2 Q3UMA3 O88811 two hybrid 10651905 direct interaction X 2 Q3UMA3 O88811 affinity chromatography technology 20697350 physical association X 2 A2AI52 O88811 affinity chromatography technology 20130268 physical association X 2 O88811 enzymatic study 25260751 direct interaction X 2 Q9DAS9 O88811 affinity chromatography technology 20697350 physical association X 2 P05064 O88811 affinity chromatography technology 20697350 physical association X 2 O88811 coimmunoprecipitation 12551915 association C 3 O88811 pull down 20697350 association C 5 O88811 O14964 confocal microscopy 15113837 colocalization X 2 O88811 O14964 anti bait coimmunoprecipitation 15113837 physical association X 2 Q80U87 O88811 coimmunoprecipitation 10982817 physical association X 2 Q80U87 O88811 filter binding 10982817 direct interaction X 2 O95630 O88811 coimmunoprecipitation 10982817 physical association X 2 Q99LI8 O88811 two hybrid 10651905 - X 2 Q99LI8 O88811 coimmunoprecipitation 10651905 - X 2 Q99LI8 O88811 coimmunoprecipitation 10651905 - X 2 Q99LI8 O88811 two hybrid 10651905 - X 2 Q99LI8 O88811 two hybrid 10651905 - X 2 Q99LI8 O88811 two hybrid 10651905 - X 2 Q99LI8 O88811 two hybrid 10651905 - X 2 Q99LI8 O88811 two hybrid 10651905 - X 2 Q99LI8 O88811 two hybrid 10651905 - X 2 Q99LI8 O88811 two hybrid 10651905 - X 2 Q99LI8 O88811 two hybrid 10651905 - X 2 Q99LI8 O88811 two hybrid 10651905 - X 2 Q99LI8 O88811 two hybrid 10651905 - X 2 Q99LI8 O88811 coimmunoprecipitation 10651905 - X 2 Q99LI8 O88811 coimmunoprecipitation 10651905 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Stam2 Usp8 MI:0019(coimmunoprecipitation)|MI:0096(pull down)|MI:0096(pull down)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology) 10982817,20130268 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(biogrid) UniProt_161829|MINT_85470|MINT_85471|UniProt_69463|UniProt_161830|BIOGRID_319328 prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait Stam2 Hgs MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10651905,20697350 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid) UniProt_108801|UniProt_185051|UniProt_172910|BIOGRID_321578|BIOGRID_322879|BIOGRID_321579 bait|bait|bait|prey|bait|prey prey|prey|prey|bait|prey|bait Stam2 Ubd MI:0114(x-ray crystallography) 16432517 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association) (biogrid) BIOGRID_315414 bait prey Stam2 Gng12 MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 20697350 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(intact)|(intact) BIOGRID_322878|UniProt_108801|UniProt_185051|UniProt_172910 bait|bait|bait|bait prey|prey|prey|prey Stam2 Crk MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 20697350 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(intact)|(intact) BIOGRID_322881|UniProt_108801|UniProt_185051|UniProt_172910 bait|bait|bait|bait prey|prey|prey|prey Stam2 Aldoa MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 20697350 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association) (intact)|(intact)|(intact)|(biogrid) UniProt_108801|UniProt_185051|UniProt_172910|BIOGRID_322880 bait|bait|bait|bait prey|prey|prey|prey Stam2 Ubc MI:0004(affinity chromatography technology) 22081111 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319327 bait prey

PPI - HINT Gene A Gene B PMID Method Quality STAM2 UBC 16432517 0114 LC STAM2 UBD 16432517 0114 LC STAM2 USP8 10982817,10982817 0019,0049 LC STAM2 HGS 10651905,10651905,10651905 0018,0004,0019 LC STAM2 ALDOA 20697350,20697350 0004,0096 LC STAM2 UBC 22081111 0004 LC STAM2 CRK 20697350,20697350 0004,0096 LC STAM2 USP8 20130268 0004 LC STAM2 HGS 10651905,10651905,10651905,20697350,12972556,20697350 0018,0004,0019,0004,0004,0096 LC STAM2 GNG12 20697350,20697350 0004,0096 LC