PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Hsp90ab1 Nod2 23019338 biogrid exp Nod2 Trpm7 24855944 intact exp Socs3 Nod2 23019338 biogrid exp Ripk2 Nod2 18775659 innatedb,i2d exp, ortho Olfm4 Nod2 20534456 dip exp, ortho Casp1 Nod2 18511561 dip exp, ortho Card9 Nod2 17187069 innatedb exp, ortho Nod2 Ndufa13 ortho Nod2 Sugt1 ortho Ripk1 Nod2 ortho Kat5 Nod2 ortho Ikbkg Nod2 ortho Rela Nod2 ortho Cad Nod2 ortho Nod2 Ankrd17 ortho Birc2 Nod2 ortho Trim27 Nod2 ortho Erbb2ip Nod2 ortho Nod1 Nod2 ortho Atg16l1 Nod2 ortho Acap1 Nod2 ortho Nod2 Nod2 ortho Nod2 Slc15a4 ortho Tle1 Nod2 ortho Ppp2r5e Nod2 ortho Nod2 Sharpin ortho Casp4 Nod2 ortho Nod2 Map3k14 ortho Oas2 Nod2 ortho Nalp1b Nod2 ortho Traf6 Nod2 ortho Trim50 Nod2 ortho Nod2 Nlrp3 ortho Birc3 Nod2 ortho Nod2 Arhgef7 ortho Mapk14 Nod2 ortho Nod2 Rbck1 ortho Ubc Nod2 ortho Slc15a3 Nod2 ortho Galnt2 Nod2 ortho Bid Nod2 ortho Cops6 Nod2 ortho Nod2 Rnf31 ortho Traf4 Nod2 ortho Nlrc4 Nod2 ortho Vim Nod2 ortho Protein Aamp Nod2 ortho Ddx58 Nod2 ortho Nod2 Trim8 ortho Protein Duox2 Nod2 ortho Xiap Nod2 ortho Nod2 Fis1 ortho Rac1 Nod2 ortho Sqstm1 Nod2 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8K3Z0 P58801 coimmunoprecipitation 15620648 association X 2 Q8K3Z0 P29452 anti bait coimmunoprecipitation 18511561 physical association X 2 Q8K3Z0 Q3UZZ4 anti bait coimmunoprecipitation 20534456 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality RIPK2 NOD2 15620648 0019 LC SOCS3 NOD2 23019338 0004 LC HSP90AB1 NOD2 23019338 0004 LC CASP1 NOD2 18511561 0006 LC RIPK2 NOD2 18775659 0007 LC OLFM4 NOD2 20534456 0006 LC NOD2 TRPM7 24855944 0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8K3Z0 P29452 NOD2 CASP1 0.21 18511561 Q923J1 Q8K3Z0 TRPM7 NOD2 0.126 24855944