PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ewsr1 Kdm5d 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G Nfe2 Kdm5d 20211142 biogrid exp G G G G Kdm5d Zbtb9 20211142 biogrid exp Kdm5d Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q62240 two hybrid 20211142 direct interaction X 2 Q62240 Q61545 two hybrid 20211142 direct interaction X 2 Q62240 Q8CDC7 two hybrid 20211142 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Nfe2 Kdm5d MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313404 bait prey Kdm5d Zbtb9 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313555 bait prey Ewsr1 Kdm5d MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313054 bait prey

PPI - HINT Gene A Gene B PMID Method Quality NFE2 KDM5D 20211142 0018 HT EWSR1 KDM5D 20211142 0018 HT KDM5D ZBTB9 20211142 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q62240 Q61545 KDM5D EWSR1 0.183 20211142 Q8CDC7 Q62240 ZBTB9 KDM5D 0.183 20211142 Q62240 Q07279 KDM5D NFE2 0.183 20211142