PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ctnnb1 Map2k5 15102471 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nap1l4 Map2k5 15102471 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lancl2 Map2k5 15102471 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fiz1 Map2k5 15102471 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dync1h1 Map2k5 15102471 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Znf516 Map2k5 15102471 intact exp Nap1l1 Map2k5 15102471 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k2 Map2k5 19903815,12912994 innatedb,i2d,intact exp, ortho Map2k5 Pard6a 12813044 innatedb,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Map2k5 19903815,15102471 innatedb,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map2k5 Map2k5 15102471 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k3 Map2k5 15102471,12912994 i2d,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Map2k5 12813044 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sirt3 Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Grb2 Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Golgb1 Map2k5 ortho Protein Kidins220 Map2k5 ortho Xrcc6 Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nfkb1 Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bad Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gch1 Map2k5 ortho G G G G G G G G G G G G G G G G G G G G Hsp90ab1 Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Asrgl1 Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkar1a Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gsk3b Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map2k5 Mapk7 ortho G G G G G G G G G G G Rpl28 Map2k5 ortho Kiaa1124 Map2k5 ortho Lnx2 Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stambp Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sptb Map2k5 ortho G G G G G G G G G G Prkcz Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G Tnnt2 Map2k5 ortho G G G G G G G G G G G G G G Trim37 Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nxf1 Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhaz Map2k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc40 Map2k5 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9WVS7 Q61084 - 12912994 - X 2 Q9WVS7 Q61084 - 12912994 - X 2 Q9WVS7 - 12912994 - X 2 Q9WVS7 - 12813044 - X 2 Q9WVS7 - 11073940,12912994 - X 2 Q9WVS7 Q61084 coimmunoprecipitation 12912994 association X 2 Q61083 Q9WVS7 pull down 12912994 physical association X 2 Q61083 Q9WVS7 coimmunoprecipitation 12912994 physical association X 2 Q61083 Q9WVS7 coimmunoprecipitation 12912994 physical association X 2 Q61083 Q9WVS7 pull down 12912994 physical association X 2 Q9WVS7 Q61084 pull down 12912994 physical association X 2 Q9WVS7 Q61084 coimmunoprecipitation 12912994 physical association X 2 Q9WVS7 Q61084 coimmunoprecipitation 12912994 physical association X 2 Q9WVS7 Q61084 pull down 12912994 physical association X 2 Q9WVS7 Q61084 two hybrid 15102471 physical association X 2 Q9WVS7 A2RSB1 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 Q61084 two hybrid 15102471 physical association X 2 Q9WVS7 Q61084 two hybrid 15102471 physical association X 2 Q9WVS7 Q61084 two hybrid 15102471 physical association X 2 Q9WVS7 Q61084 two hybrid 15102471 physical association X 2 Q9WVS7 Q61084 two hybrid 15102471 physical association X 2 Q9WVS7 Q61084 two hybrid 15102471 physical association X 2 Q9WVS7 Q61084 two hybrid 15102471 physical association X 2 Q9WVS7 Q61084 two hybrid 15102471 physical association X 2 Q9WVS7 Q61084 two hybrid 15102471 physical association X 2 Q9WVS7 Q61084 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9WVS7 P28656 two hybrid 15102471 physical association X 2 Q9JJK2 Q9WVS7 two hybrid 15102471 physical association X 2 Q64337 Q9WVS7 two hybrid 15102471 physical association X 2 Q64337 Q9WVS7 two hybrid 15102471 physical association X 2 Q64337 Q9WVS7 two hybrid 15102471 physical association X 2 Q9WVS7 Q02248 two hybrid 15102471 physical association X 2 Q9WVS7 Q3TRV0 two hybrid 15102471 physical association X 2 Q9WVS7 Q3TRV0 two hybrid 15102471 physical association X 2 Q9WVS7 Q9JHU4 two hybrid 15102471 physical association X 2 Q9WVS7 Q7TSH3 two hybrid 15102471 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality NAP1L1 MAP2K5 15102471 0018 LC CTNNB1 MAP2K5 15102471 0018 LC MAP3K2 MAP2K5 11073940,12912994,12912994,12912994,12912994 0018,0018,0019,0004,0096 LC MAP3K3 MAP2K5 12912994,12912994,12912994,15102471 0096,0004,0019,0018 LC SQSTM1 MAP2K5 19903815,19903815,15102471 0096,0107,0018 LC NAP1L4 MAP2K5 15102471 0018 LC ZNF516 MAP2K5 15102471 0018 LC DYNC1H1 MAP2K5 15102471 0018 LC LANCL2 MAP2K5 15102471 0018 LC FIZ1 MAP2K5 15102471 0018 LC MAP2K5 PARD6A 12813044,12813044 0018,0019 LC MAP3K2 MAP2K5 12912994,12912994,12912994,19903815,12912994 0018,0019,0004,0096,0096 LC MAP3K3 MAP2K5 12912994,12912994,12912994 0096,0004,0019 LC SQSTM1 MAP2K5 19903815,19903815 0096,0107 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9WVS7 Q9JHU4 MAP2K5 DYNC1H1 0.183 15102471 Q9WVS7 Q9JJK2 MAP2K5 LANCL2 0.183 15102471 Q9WVS7 Q9WTJ4 MAP2K5 FIZ1 0.183 15102471 Q9WVS7 Q61083 MAP2K5 MAP3K2 0.507 12912994 Q9WVS7 Q02248 MAP2K5 CTNNB1 0.183 15102471 Q9WVS7 Q64337 MAP2K5 SQSTM1 0.183 15102471 Q9WVS7 Q78ZA7 MAP2K5 NAP1L4 0.183 15102471 Q9WVS7 Q7TSH3 MAP2K5 ZNF516 0.183 15102471 Q9WVS7 Q61084 MAP2K5 MAP3K3 0.597 12912994,15102471 Q9WVS7 P28656 MAP2K5 NAP1L1 0.183 15102471