PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Map3k5 Ppp3cb 16648474 mint,intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Spag9 15767678 biogrid exp P Map3k5 Csf1 16267818 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Raf1 11427728 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Mapk8ip3 15767678 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Pgam5 19590015 dip exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Traf2 17015619 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G Map3k5 Ppp3r1 16648474 mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Map2k7 i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Znf622 21771788 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Dusp19 i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Rb1cc1 17015619 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Map3k6 17210579 intact exp, ortho G G G G G G G G G G Map3k5 Daxx 9743501 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Strap 19880523 innatedb exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Park7 17331951 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Akt1 11154276 innatedb,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Arrb2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Rps6ka5 ortho Map3k5 Alk ortho G G G G G Map3k5 Gna13 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Cct2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Traf1 ortho G G G Map3k5 Psmc1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Tnfrsf25, Tumor necrosis factor receptor superfamily, member 25, isoform CRA_b Map3k5 ortho G G Map3k5 Traf6 ortho G G G G G G G G G G G G G G G G G G Map3k5 Arrb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Ptk2b ortho GP G G G G G G G G G G G G G G G G G G G G G G Map3k5 Socs3 ortho G G G G G G G G G G G G G G G G G G G G G G Map3k5 Btk ortho G G G G G Map3k5 Ywhab ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Prkaa2 ortho P Map3k5 Ahcyl2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Nedd4l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Traf5 ortho G G G G G G G G G G G G G G G G Map3k5 Map3k9 ortho Map3k5 Ppp5c ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Cdkn1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Nrtn ortho G G G G G G G G G G G G G G G G G G G G G Map3k5 Map3k5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map2k3 Map3k5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Ywhah ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Map3k2 ortho Map3k5 Gstm2 ortho GP G G G G G G G G G G G G G G G G G G G G G Map3k5 Map4k4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Tnik ortho P Map3k5 Ptpn11 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Ywhaz ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Tpd52l1 ortho GP G G G G G G G G G G G G G G G G G G G G Map3k5 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Atad3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Map3k10 ortho Map3k5 Gadd45b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Pik3r1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Dusp4 ortho Map3k5 Dab2ip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Socs1 ortho Map3k5 Prkca ortho GP G G G G G G G G G G G G G G G G G G G Map3k5 Pdcd6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Eif2ak2 ortho GP G G G G G G G G G G G G G G G G G G G Map3k5 Fgfr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Mapk11 ortho G G G G G G G G Map3k5 Hsp90ab1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Map2k4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Mcrs1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Txn2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Gemin5 ortho P Map3k5 Mbp ortho GP G G G G G G G G G G G G G G G G G G G Map3k5 Gna12 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Camkk2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Psmc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Mapk13 ortho GP G G G G G G G G G G G G G G Map3k5 Map3k3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Dmd ortho GP G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Map2k6 ortho GP G G G G G G G G G G G G G G G G G G G G Map3k5 Mapk1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Map3k11 ortho G G G G G G G G G G G G G G G G G G Map3k5 Sgk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Akt2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Ern1 ortho G G G G G Map3k5 Mapk14 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 App ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Cflar ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Mapkapk5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Hspa4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Mapk9 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Dyrk1a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Sfn ortho P G G G G G G Map3k5 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Mapkapk2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Taok3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Pkn1 ortho P Map3k5 Jak1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Txn ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Psmc3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Tnnt2 ortho GP G G G G G G G G G G G Map3k5 Tnfaip3 ortho G G G Map3k5 Map4k1 ortho P G G G G G Map3k5 Stk39 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Ywhag ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Jak2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Mapk8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Prkab2 ortho Map3k5 Mink1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Ahsa1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Dapk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Cul1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Tulp3 ortho G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Igf1r ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Glrx ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Myc ortho G G G G G G G G G G G G G G G G G G G Map3k5 Map4k5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Mapkapk3 ortho Map3k5 Cib1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Gspt1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Hsp90aa1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Tnfsf13b ortho G G G G G G G Map3k5 Taok2 ortho Map3k5 Traf3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k4 Map3k5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Bax ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Birc5 ortho G G G G G G G G G G G Ep300 Map3k5 ortho P Map3k5 Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Psmc5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Pink1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Ywhae ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Psmc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Cdc25a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Fas ortho G G G G G G G G G G G G G G G Map3k5 Crebbp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q3UKR0 O35099 affinity chromatography technology 9743501 physical association X 2 P39429 O35099 pull down 17015619 direct interaction X 2 P39429 O35099 pull down 17015619 direct interaction X 2 Q99LX0 O35099 affinity chromatography technology 17331951 physical association X 2 O35099 Q9ESN9-3 affinity chromatography technology 15767678 physical association X 2 A0A024R384 O35099 enzymatic study 17331951 direct interaction X 2 Q9ESK9 O35099 pull down 17015619 direct interaction X 2 Q9ESK9 O35099 pull down 17015619 direct interaction X 2 O35099 affinity chromatography technology 15767678 physical association X 2 O35099 coimmunoprecipitation 15782121 association C 4 O35099 P70196 anti bait coimmunoprecipitation 15864310 association X 2 O35099 Q8BX10 anti bait coimmunoprecipitation 19590015 physical association X 2 O35099 pull down 16267818 association C 41 Q63810 O35099 pull down 16648474 physical association X 2 Q63810 O35099 two hybrid 16648474 physical association X 2 Q63810 O35099 pull down 16648474 physical association X 2 P29067 O35099 coimmunoprecipitation 11090355 physical association X 2 P48453 O35099 inferred by author 16648474 genetic interaction X 2 P48453 O35099 genetic interference 16648474 genetic interaction X 2 Q9WTR2 O35099 anti bait coimmunoprecipitation 17210579 physical association X 2 O35099 P31750 anti bait coimmunoprecipitation 11154276 physical association X 2 O35099 Q91VY9 anti bait coimmunoprecipitation 21771788 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Map3k5 Ppp3r1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 16648474 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_167641|UniProt_167642|UniProt_167639 bait|prey|prey prey|bait|bait Map3k5 Map3k6 MI:0018(two hybrid) 17210579 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_166570 bait prey Map3k5 Ppp3cb MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 16648474 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0208(genetic interaction)|MI:0208(genetic interaction) (intact)|(intact) UniProt_167640|UniProt_167643 neutral component|neutral component neutral component|neutral component Map3k5 Akt1 MI:0424(protein kinase assay) 11154276 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_160613 prey bait Map3k5 Park7 MI:0004(affinity chromatography technology) 17331951 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_323153 bait prey Map3k5 Spag9 MI:0004(affinity chromatography technology) 15767678 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_327647 prey bait Map3k5 Znf622 MI:0006(anti bait coimmunoprecipitation) 21771788 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_172151 prey bait Map3k5 Traf2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17015619 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_322558|BIOGRID_322557 prey|bait bait|prey Map3k5 Rb1cc1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17015619 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_322555|BIOGRID_322553 bait|prey prey|bait Map3k5 Mapk8ip3 MI:0004(affinity chromatography technology) 15767678 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_327646 prey bait Map3k5 Daxx MI:0004(affinity chromatography technology) 9743501 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_312180 bait prey

PPI - HINT Gene A Gene B PMID Method Quality MAP3K5 HSP90AB1 15782121 0019 LC MAP3K5 AKT1 15782121 0019 LC MAP3K5 TRAF6 15864310,15864310 0006,0019 LC MAP3K5 PPP3R1 16648474,16648474 0018,0096 LC MAP3K5 DAXX 9743501 0004 LC MAP3K5 CSF1 16267818 0096 LC MAP3K5 TAL1 19346495 0007 LC MAP3K5 AKT1 11154276,11154276 0006,0007 LC MAP3K5 TRAF2 17015619 0096 LC MAP3K5 PPP3CB 16648474 0363 LC MAP3K5 TRAF6 15864310,15864310 0006,0019 LC MAP3K5 SHANK3 27507650 0004 LC MAP3K5 SPAG9 15767678 0004 LC MAP3K5 PPP3R1 16648474,16648474 0018,0096 LC MAP3K5 PGAM5 19590015 0006 LC MAP3K5 ZNF622 21771788 0006 LC MAP3K5 PARK7 17331951 0004 LC MAP3K5 RAF1 11427728 0007 LC MAP3K5 RB1CC1 17015619 0096 LC MAP3K5 MAPK8IP3 15767678 0004 LC MAP3K5 MAP3K6 17210579 0006 LC MAP3K5 STRAP 19880523 0007 LC