PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Rybp Rnf2 10369680,20471950,23395003,22496869,17070805,22325148 biogrid,i2d,intact exp Cbx2 Rybp 10369680 i2d,intact exp Rybp Eed 24457600 biogrid exp Pou5f1 Rybp 20362541,17093407 biogrid,i2d,intact exp L3mbtl2 Rybp 22770845 biogrid exp Pcgf2 Rybp 22325148 biogrid,intact exp Ywhae Rybp 16615898 intact exp Tfcp2l1 Rybp 20362541 biogrid,intact exp Nanog Rybp 23892456 biogrid,intact exp Rybp Cbx7 22325148 intact exp Rybp Pcgf1 23395003,22325148 biogrid,intact exp Rybp Pcgf6 22325148 biogrid,intact exp Rybp Rybp 22325148 biogrid,intact exp Kdm2b Rybp 23395003 biogrid exp Rybp Trpm7 24855944 intact exp Nkx2-2 Rybp 22325148 intact exp Hoxa7 Rybp 22325148 intact exp Gata4 Rybp 22325148 intact exp Cdx2 Rybp 22325148 intact exp Msx1 Rybp 22325148 intact exp Atoh1 Rybp 22325148 intact exp Ring1 Rybp 10369680,17070805,22325148 biogrid,i2d,intact exp Pax3 Rybp 22325148 intact exp

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8CCI5 P30658 - 10369680 - X 2 Q8CCI5 Q9CQJ4 - 10369680 - X 2 Q8CCI5 - 10369680 - X 2 Q8CCI5 P25490 - 10369680 - X 2 Q8CCI5 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 P59178 affinity chromatography technology 22770845 physical association X 2 Q8CCI5 P59178 affinity chromatography technology 22770845 physical association X 2 Q8CCI5 affinity chromatography technology 23395003 physical association X 2 Q8CCI5 A2RS90 affinity chromatography technology 23892456 physical association X 2 Q8CCI5 Q921E6 affinity chromatography technology 24457600 physical association X 2 Q8CCI5 affinity chromatography technology 20362541 physical association X 2 Q8CCI5 affinity chromatography technology 17093407 physical association X 2 Q8CCI5 P0CG48 pull down 17070805 direct interaction X 2 Q8CCI5 P0CG48 affinity chromatography technology 17070805 physical association X 2 Q8CCI5 Q9CQJ4 affinity chromatography technology 22496869 physical association X 2 Q8CCI5 P23798 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 O35730 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 Q99NA9 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 Q9CQJ4 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 P23798 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 P23798 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 P23798 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 Q9CQJ4 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 Q9CQJ4 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 Q8CCI5 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 Q6P1G2-4 affinity chromatography technology 23395003 physical association X 2 Q8CCI5 Q9CQJ4 affinity chromatography technology 23395003 physical association X 2 Q8CCI5 Q3UNW5 affinity chromatography technology 20362541 physical association X 2 Q8CCI5 O35730 affinity chromatography technology 17070805 physical association X 2 Q8CCI5 Q9CQJ4 affinity chromatography technology 17070805 physical association X 2 Q8CCI5 Q9CQJ4 affinity chromatography technology 20471950 physical association X 2 Q8CCI5 anti tag coimmunoprecipitation 20362541 association C 93 Q8CCI5 anti tag coimmunoprecipitation 22325148 association C 10 Q8CCI5 molecular sieving 22325148 physical association C 4 Q8CCI5 anti bait coimmunoprecipitation 22325148 association C 4 Q8CCI5 anti bait coimmunoprecipitation 22325148 association C 4 Q8CCI5 anti tag coimmunoprecipitation 23892456 association C 143 Q8CCI5 P30658 pull down 10369680 physical association X 2 Q8CCI5 P30658 pull down 10369680 direct interaction X 2 Q8CCI5 P30658 pull down 10369680 direct interaction X 2 Q8CCI5 molecular sieving 22325148 physical association C 3 Q8CCI5 anti tag coimmunoprecipitation 22325148 association C 3 Q8CCI5 anti bait coimmunoprecipitation 22325148 association C 3 Q8CCI5 anti bait coimmunoprecipitation 22325148 association C 3 Q8CCI5 anti tag coimmunoprecipitation 22325148 association C 6 Q8CCI5 anti tag coimmunoprecipitation 20362541 association C 45 Q8CCI5 anti bait coimmunoprecipitation 22325148 association C 5 Q8CCI5 anti tag coimmunoprecipitation 22325148 association C 5 Q8CCI5 anti tag coimmunoprecipitation 22325148 association C 10 Q8CCI5 O35730 pull down 10369680 direct interaction X 2 Q8CCI5 Q9CQJ4 anti bait coimmunoprecipitation 10369680 physical association X 2 Q8CCI5 O35730 anti bait coimmunoprecipitation 10369680 physical association X 2 Q8CCI5 Q9CQJ4 anti bait coimmunoprecipitation 10369680 physical association X 2 Q8CCI5 P25490 pull down 10369680 physical association X 2 Q8CCI5 Q8ST83 pull down 10369680 physical association X 2 Q8CCI5 O35730 two hybrid 10369680 physical association X 2 Q8CCI5 P25490 pull down 10369680 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Pou5f1 Rybp MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 17093407,20362541 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(intact)|(intact)|(biogrid)|(biogrid)|(intact) UniProt_170695|UniProt_107196|UniProt_107195|BIOGRID_313920|BIOGRID_314252|UniProt_170681 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey Rybp Pcgf6 MI:0071(molecular sieving)|MI:0004(affinity chromatography technology) 22325148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_174817|BIOGRID_320769 bait|bait prey|prey Rybp Eed MI:0027(cosedimentation)|MI:0004(affinity chromatography technology) 16615898,24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association) (intact)|(biogrid) UniProt_167137|BIOGRID_331808 neutral component|prey neutral component|bait L3mbtl2 Rybp MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22770845 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_328083|BIOGRID_328051 bait|bait prey|prey Tfcp2l1 Rybp MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 20362541 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association) (intact)|(intact)|(biogrid) UniProt_170696|UniProt_107197|BIOGRID_314043 bait|bait|bait prey|prey|prey Rybp Pcgf1 MI:0071(molecular sieving)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22325148,23395003 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_174817|BIOGRID_329743|BIOGRID_320771 bait|prey|bait prey|bait|prey Cbx2 Rybp MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 10369680 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_66132|UniProt_39077|UniProt_66128|UniProt_160382|UniProt_160385|UniProt_66131|UniProt_160386 prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait Ring1 Rybp MI:0071(molecular sieving)|MI:0027(cosedimentation)|MI:0096(pull down)|MI:0096(pull down)|MI:0027(cosedimentation)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down) 10369680,16615898,17070805,22325148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|(intact) UniProt_174817|UniProt_167137|UniProt_66127|UniProt_160381|UniProt_167133|BIOGRID_316004|BIOGRID_320768|UniProt_160378|UniProt_160380 prey|neutral component|prey|prey|neutral component|prey|prey|bait|bait bait|neutral component|bait|bait|neutral component|bait|bait|prey|prey Pcgf2 Rybp MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving) 22325148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) BIOGRID_320779|BIOGRID_320781|BIOGRID_320766|BIOGRID_320772|UniProt_174817|UniProt_174815|UniProt_174854|UniProt_174851|UniProt_174819|UniProt_174856|UniProt_174812|UniProt_174852|UniProt_174857|UniProt_174816|UniProt_174853 bait|prey|bait|prey|prey|prey|prey|prey|bait|bait|neutral component|prey|bait|bait|prey prey|bait|prey|bait|bait|bait|bait|bait|prey|prey|neutral component|prey|prey|prey|prey Nanog Rybp MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 23892456 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_177306|BIOGRID_331308 bait|bait prey|prey Kdm2b Rybp MI:0004(affinity chromatography technology) 23395003 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_329736 bait prey Rybp Rnf2 MI:0071(molecular sieving)|MI:0027(cosedimentation)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0027(cosedimentation)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving) 10369680,16615898,17070805,20471950,22325148,22496869,23395003 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(biogrid)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_174817|UniProt_167137|BIOGRID_316005|UniProt_160379|UniProt_160377|BIOGRID_320482|BIOGRID_320782|BIOGRID_320788|BIOGRID_329739|BIOGRID_319383|BIOGRID_320770|UniProt_174813|UniProt_174815|UniProt_174854|UniProt_174851|UniProt_167133|UniProt_174812|UniProt_174856|UniProt_174852 bait|neutral component|bait|bait|prey|prey|bait|prey|prey|prey|bait|neutral component|bait|bait|bait|neutral component|neutral component|prey|prey prey|neutral component|prey|prey|bait|bait|prey|bait|bait|bait|prey|neutral component|prey|prey|prey|neutral component|neutral component|prey|bait

PPI - HINT Gene A Gene B PMID Method Quality RING1 RYBP 10369680,10369680,10369680 0006,0018,0096 LC YWHAE RYBP 16615898 0027 LC RYBP CBX7 22325148 0071 LC RING1 RYBP 10369680,17070805,10369680,22325148,10369680,22325148 0006,0004,0018,0004,0096,0007 LC POU5F1 RYBP 20362541,17093407,20362541 0004,0004,0007 LC PCGF2 RYBP 22325148,22325148,22325148 0006,0004,0007 LC CBX2 RYBP 10369680 0096 LC L3MBTL2 RYBP 22770845 0004 LC TFCP2L1 RYBP 20362541,20362541 0004,0007 LC KDM2B RYBP 23395003 0004 LC NANOG RYBP 23892456,23892456 0007,0004 LC RYBP RYBP 22325148 0004 LC RYBP PCGF1 22325148,22325148,23395003 0004,0007,0004 LC RYBP EED 24457600 0004 LC RYBP TRPM7 24855944 0006 LC RYBP PCGF6 22325148,22325148 0004,0007 LC RYBP RNF2 10369680,17070805,22325148,22325148,22325148,20471950,23395003,22496869 0006,0004,0004,0006,0007,0004,0004,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8CCI5 P59178 RYBP L3MBTL2 0.21 22770845 Q8CCI5 P62259 RYBP YWHAE 0.081 16615898 Q8R023 Q8CCI5 PCGF1 RYBP 0.396 22325148,23395003 Q8ST83 Q8CCI5 PHO RYBP 0.21 10369680 Q8VDS3 Q8CCI5 CBX7 RYBP 0.126 22325148 Q8CCI5 P0CG48 RYBP UBC 0.454 17070805 Q8CCI5 Q6P1G2 RYBP KDM2B 0.21 23395003 Q8CCI5 Q8CCI5 RYBP RYBP 0.155 22325148 Q8CCI5 Q3UNW5 RYBP TFCP2L1 0.236 20362541 Q8CCI5 Q80Z64 RYBP NANOG 0.236 23892456 Q99NA9 Q8CCI5 PCGF6 RYBP 0.236 22325148 Q8CCI5 P25490 RYBP YY1 0.454 10369680 Q8CCI5 O35730 RYBP RING1 0.772 22325148,17070805,10369680 Q8CCI5 P23798 RYBP PCGF2 0.554 22325148 Q8CCI5 P20263 RYBP POU5F1 0.332 17093407,20362541 Q9CQJ4 Q8CCI5 RNF2 RYBP 0.863 22325148,17070805,22496869,20471950,10369680,23395003 Q8CCI5 P30658 RYBP CBX2 0.623 10369680 Q921E6 Q8CCI5 EED RYBP 0.126 24457600 Q923J1 Q8CCI5 TRPM7 RYBP 0.126 24855944