PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ube2n Ywhae 16615898 intact exp P Ikbkg Ube2n 18635759 biogrid exp P Ube2n Tax1bp1 20185725 innatedb,biogrid exp P Map3k1 Ube2n 18635759 biogrid exp Ube2n Dlg4 19455133 intact exp P Got1 Ube2n 15627969 intact exp P Ube2n Rnf41 19483718 biogrid exp Tcf3 Ube2n 22354994 biogrid exp Ripk2 Ube2n 17947236 innatedb exp P Cd40 Ube2n 18635759 innatedb,biogrid exp Ube2n Tlr4 19898473 innatedb,biogrid exp Ube2n Hsd3b4 16615898 intact exp Ube2n Map3k7 19898473 innatedb,biogrid exp P Ube2n Eed 24457600 innatedb,biogrid exp Ube2n Ube2v2 11406273,12039045 biogrid,i2d exp, ortho P Ube2n Traf6 19136968,20185725,21765415 innatedb,biogrid,intact exp, ortho Ube2n Stub1 16307917 intact exp, ortho P Ube2n Ube2v1 11406273,12039045 biogrid,i2d exp, ortho P Traf2 Ube2n 20185725,21765415 innatedb,biogrid,intact exp, ortho Ubc Ube2n 20185725 biogrid exp, ortho P Ube2n Rnf8 21706008 biogrid exp, ortho Tp53 Ube2n 17000756 biogrid exp, ortho Ube2n Tnfaip3 20185725 innatedb,biogrid exp, ortho Ube2n Chfr 21706008 biogrid exp, ortho Ube2n Hgs ortho P Ube2n Herc2 ortho P Ube2n Gga2 ortho P Ube2n Ripk1 ortho P Ube2n Appl1 ortho P Rad23b Ube2n ortho P Ube2n Rnf182 ortho Ube2n Arih2 ortho P Ube2n Rbck1 ortho P Ube2n Rnf128 ortho Ube2n Gripap1 ortho P Ube2n Rnf122 ortho Ube2n Trim11 ortho Ube2d1 Ube2n ortho Ube2n Cuedc1 ortho Ube2n Vasp ortho P Ube2n Phgdh ortho P Ube2n F12 ortho Ube2n Rnf168 ortho Ube2n Aspdh ortho Ube2n Mfn2 ortho Ube2n Trim23 ortho Ube2n March5 ortho P Ube2n Rnf152 ortho Ube2n Sh3rf2 ortho Ube2n Ube2n ortho P Ube2n Cblb ortho Ube2n Trim50 ortho Ube2n Fh ortho P Mdm2 Ube2n ortho Brca1 Ube2n ortho Ikbkb Ube2n ortho P Ube2n Ankrd13a ortho P Ube2n Faf2 ortho P Ube2n Creld1 ortho P Dnajb6 Ube2n ortho P Ube2n Znrf3 ortho Ube2n Bcl10 ortho Ube2n Cnot4 ortho Ube2n Mfsd6 ortho Ube2n Protein Znrf4, Zinc and ring finger 4 ortho Ube2n Rnf167 ortho Ube2n Thra ortho Ube2n Rnf130 ortho Ube2n Mib1 ortho P Ube2n Park2 ortho Ube2d3 Ube2n ortho P Ube2n Uba1 ortho P Ube2n Txndc17 ortho P Ube2n Epn1 ortho P Ube2n Rnf126 ortho Ube2n Slc9b2 ortho Ube2n Rbp2 ortho P Ube2n Trim33 ortho Ube2n Mib2 ortho Ube2n Sh3rf1 ortho Ube2n Amfr ortho Birc7 Ube2n ortho Ube2n Neurl1 ortho Ube2n Mkrn3 ortho Ube2n Birc2 ortho Ube2n Aurka ortho Ube2n Dennd6b ortho Ube2n Usp14 ortho P Ube2n Fkbp6 ortho Ube2n Riok3 ortho P Ube2n Nme2 ortho P Ube2n Dzip3 ortho Ube2n Cdc5l ortho P Ube2n Chuk ortho Ube2n Malt1 ortho Ube2n Ube2a ortho P Ube2n Zdhhc5 ortho Rad23a Ube2n ortho P Rnf165 Ube2n ortho Ube2n Atp6v1h ortho P Krt36 Ube2n ortho P Ube2n Ubl5 ortho P Ube2n Cep85 ortho Ube2n Znrf1 ortho Vhl Ube2n ortho Ppia Ube2n ortho P Ube2n Peli2 ortho Ube2n Mid2 ortho Bard1 Ube2n ortho Ube2n Trim17 ortho Ube2n Ints3 ortho P Ube2n Fam188a ortho P Fn1 Ube2n ortho P Ube2n Peli1 ortho Ube2n Nedd4l ortho P Ube2n Lrsam1 ortho P Rc3h2 Ube2n ortho P Ube2n Acaca ortho P Ube2n Ube2e2 ortho P Ube2n Nudt6 ortho Ube2n Bag3 ortho P Ube2n Ascc2 ortho P Ube2n Dtx1 ortho Ube2n Stambpl1 ortho P Ube2n Dnajb2 ortho P Ube2n Peli3 ortho Ube2e1 Ube2n ortho P Protein Fam184a Ube2n ortho Ube2k Ube2n ortho P Ube2n Hip1 ortho P Ube2n Dtl ortho Ube2n Pccb ortho P Ube2n Ufd1l ortho P Ube2n Trim27 ortho Ube2n Shprh ortho P Ube2n Card14 ortho P Slc2a4 Ube2n ortho Nfx1 Ube2n ortho P Ube2n Sardh ortho P Ube2n Mylip ortho Ube2n Arf4 ortho P Ube2n Pja2 ortho Ube2n Elavl1 ortho P Ube2n Cadps2 ortho P Ldhb Ube2n ortho P Ube2n Rfwd3 ortho Ube2n Idh3a ortho P Ube2n Trim21 ortho Ube2n Trim25 ortho P Ube2n Pc ortho P Ube2n Cab39 ortho P Impact Ube2n ortho Ube2n Pinx1 ortho Cd74 Ube2n ortho P Ube2n Topors ortho Vps33b Ube2n ortho P Ube2n Dcun1d2 ortho Ube2n Apex2 ortho Mid1 Ube2n ortho Ube2n Hip1r ortho P Ube2n Trim32 ortho P Ube2n Dcun1d1 ortho P Ube2n Rnf103 ortho Ube2n Rnf111 ortho Ube2n Calcium-transporting ATPase ortho P Ube2n Trim72 ortho Ube2n Tspan17 ortho Ube2n Siah1a ortho Ube2n Hbs1l ortho P Ube2n Rnf43 ortho Ube2n March7 ortho Ube2n Rnf115 ortho Ube2n Otub2 ortho Ube2n Trim28 ortho P Ube2n Rnf11 ortho Ube2n Isg15 ortho P Kif1c Ube2n ortho P Ube2n Xiap ortho Ube2n Smurf1 ortho Hspb1 Ube2n ortho P Hsp90aa1 Ube2n ortho P Ube2n Epha1 ortho Ube2n Bfar ortho Ube2n Znrf2 ortho P Ube2n Atxn3 ortho P Ube2n Hltf ortho P Ube2n Snw1 ortho P Ube2n Prkab1 ortho P Rnf5 Ube2n ortho Ube2n Ikbke ortho Ube2n Actr2 ortho P Tnf Ube2n ortho Ube2n Gnpnat1 ortho P Ube2n Rnf4 ortho Ube2n Acox1 ortho P Rnf13 Ube2n ortho Ube2n Rhbdd1 ortho Ube2n Pcca ortho P Ube2n D17Wsu92e ortho Ube2n Nbn ortho Ube2n Trim39 ortho Ube2n Poli ortho Vcam1 Ube2n ortho P Birc3 Ube2n ortho Ube2n Acot13 ortho P Ube2n Arih1 ortho P Ube2n Hadh ortho P Ube2n Rnf135 ortho Ube2n Rnf34 ortho Ldhc Ube2n ortho P Lgals1 Ube2n ortho P Ube2n Tmem189 ortho Ube2n Bap1 ortho Ube2n Ankrd13d ortho P Ube2n Cdk2 ortho P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q569Y6 P61089 - 12039045 - X 2 P61089 Q4VBX4 - 12039045 - X 2 P39429 P61089 affinity chromatography technology 20185725 physical association X 2 P39429 P61089 affinity chromatography technology 21765415 physical association X 2 Q549C9 P61089 affinity chromatography technology 17000756 physical association X 2 P61089 pull down 25260751 direct interaction X 2 P61089 affinity chromatography technology 18635759 physical association X 2 P61089 E9PVV2 affinity chromatography technology 22354994 physical association X 2 P61089 Q921E6 affinity chromatography technology 24457600 physical association X 2 P61089 Q3TBB9 affinity chromatography technology 20185725 physical association X 2 P61089 affinity chromatography technology 18635759 physical association X 2 Q569Y6 P61089 two hybrid 11406273 direct interaction X 2 Q569Y6 P61089 two hybrid 12039045 direct interaction X 2 P0CG48 P61089 pull down 12039045 direct interaction X 2 P61089 Q4VBX4 two hybrid 11406273 direct interaction X 2 P61089 A0M8W4 pull down 12039045 direct interaction X 2 P61089 Q4VBX4 two hybrid 12039045 direct interaction X 2 P61089 P70196 affinity chromatography technology 20185725 physical association X 2 P61089 Q3UKC1 affinity chromatography technology 20185725 physical association X 2 P61089 P0CG50 affinity chromatography technology 20185725 physical association X 2 P61089 Q9QUK6 affinity chromatography technology 19898473 physical association X 2 P61089 affinity chromatography technology 19898473 physical association X 2 P61089 P70196 affinity chromatography technology 21765415 physical association X 2 P61089 O88522 affinity chromatography technology 18635759 physical association X 2 P61089 anti bait coimmunoprecipitation 18635759 association C 5 P61089 anti bait coimmunoprecipitation 18635759 association C 7 P61089 anti bait coimmunoprecipitation 18635759 association C 4 P61089 anti bait coimmunoprecipitation 18635759 association C 9 P61089 cosedimentation 16615898 colocalization C 1216 P61089 anti bait coimmunoprecipitation 21765415 association C 7 P61089 x-ray crystallography 16307917 physical association C 3 P61089 anti bait coimmunoprecipitation 21765415 association C 7 P61089 anti tag coimmunoprecipitation 19455133 association C 226 P61089 affinity chromatography technology 15627969 association C 16

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ube2n Ube2v2 MI:0018(two hybrid)|MI:0096(pull down) 11406273,12039045 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_325450|BIOGRID_315410 prey|prey bait|bait Tp53 Ube2n MI:0096(pull down) 17000756 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_312472 bait prey Ube2n Tax1bp1 MI:0004(affinity chromatography technology) 20185725 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_318882 prey bait Ube2n Eed MI:0027(cosedimentation)|MI:0004(affinity chromatography technology) 16615898,24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association) (intact)|(biogrid) UniProt_167137|BIOGRID_332391 neutral component|prey neutral component|bait Ikbkg Ube2n MI:0027(cosedimentation)|MI:0004(affinity chromatography technology) 16615898,18635759 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association) (intact)|(biogrid) UniProt_167134|BIOGRID_319915 neutral component|bait neutral component|prey Ube2n Map3k7 MI:0004(affinity chromatography technology) 19898473 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319314 prey bait Ube2n Tlr4 MI:0004(affinity chromatography technology) 19898473 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319302 prey bait Ubc Ube2n MI:0004(affinity chromatography technology) 20185725 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_318886 prey bait Ube2n Ube2v1 MI:0096(pull down)|MI:0018(two hybrid) 11406273,12039045 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_315409|BIOGRID_325451 prey|prey bait|bait Traf2 Ube2n MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0424(protein kinase assay)|MI:0424(protein kinase assay) 20185725,21765415 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(biogrid)|(intact)|(intact) BIOGRID_319667|BIOGRID_318876|UniProt_113516|UniProt_171878 bait|bait|bait|bait prey|prey|prey|prey Tcf3 Ube2n MI:0004(affinity chromatography technology) 22354994 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320656 bait prey Ube2n Tnfaip3 MI:0004(affinity chromatography technology) 20185725 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_318887 bait prey Ube2n Traf6 MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0424(protein kinase assay)|MI:0424(protein kinase assay) 20185725,21765415 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(biogrid)|(intact)|(intact) BIOGRID_318870|BIOGRID_319659|UniProt_113517|UniProt_171879 prey|prey|prey|prey bait|bait|bait|bait Cd40 Ube2n MI:0004(affinity chromatography technology) 18635759 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319904 bait prey

PPI - HINT Gene A Gene B PMID Method Quality RIPK2 UBE2N 17947236 0256 LC UBE2N YWHAE 16615898 0027 LC UBE2N HSD3B4 16615898 0027 LC UBE2N UBE2V1 12039045,11406273 0018,0018 LC UBE2N UBE2V2 12039045,11406273 0018,0018 LC UBE2N STUB1 16307917 0114 LC IKBKG UBE2N 18635759 0004 LC TP53 UBE2N 17000756 0004 LC GOT1 UBE2N 15627969 0004 LC UBC UBE2N 20185725 0004 LC TCF3 UBE2N 22354994 0004 LC CD40 UBE2N 18635759 0004 LC TRAF2 UBE2N 20185725,21765415,21765415,20185725 0007,0006,0004,0004 LC MAP3K1 UBE2N 18635759 0004 LC UBE2N TRAF6 19136968,20185725,21765415,20185725,21765415 0096,0007,0004,0004,0006 LC UBE2N TAX1BP1 20185725,20185725 0007,0004 LC UBE2N TNFAIP3 20185725,20185725 0007,0004 LC UBE2N MAP3K7 19898473 0004 LC UBE2N DLG4 19455133 0007 LC UBE2N CHFR 21706008 0096 LC UBE2N RNF41 19483718 0096 LC UBE2N RNF8 21706008 0096 LC UBE2N EED 24457600 0004 LC UBE2N DLGAP1 27507650 0004 LC UBE2N TLR4 19898473 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P61089 P15806 UBE2N TCF3 0.126 22354994 P61089 P0CG50 UBE2N UBC 0.21 20185725 Q15819 P61089 UBE2V2 UBE2N 0.309 12039045 Q60769 P61089 TNFAIP3 UBE2N 0.21 20185725 Q61767 P61089 HSD3B4 UBE2N 0.081 16615898 Q62073 P61089 MAP3K7 UBE2N 0.21 19898473 P62259 P61089 YWHAE UBE2N 0.081 16615898 Q8VC56 P61089 RNF8 UBE2N 0.309 21706008 P61089 O88522 UBE2N IKBKG 0.21 18635759 Q810L3 P61089 CHFR UBE2N 0.309 21706008 Q8BH75 P61089 RNF41 UBE2N 0.309 19483718 P61089 P02340 UBE2N TP53 0.21 17000756 P61089 P05201 UBE2N GOT1 0.21 15627969 Q9CZY3 P61089 UBE2V1 UBE2N 0.523 11406273,12039045 Q9D2M8 P61089 UBE2V2 UBE2N 0.523 11406273,12039045 Q62108 P61089 DLG4 UBE2N 0.236 19455133 P61089 P39429 UBE2N TRAF2 0.376 20185725,21765415 P70196 P61089 TRAF6 UBE2N 0.569 19136968,20185725,21765415 Q921E6 P61089 EED UBE2N 0.126 24457600 Q9D415 P61089 DLGAP1 UBE2N 0.126 27507650 P61089 P27512 UBE2N CD40 0.21 18635759 Q9QUK6 P61089 TLR4 UBE2N 0.21 19898473 Q3UKC1 P61089 TAX1BP1 UBE2N 0.21 20185725