PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Hist2h2be Rnf8 21706008 biogrid exp Tpp1 Rnf8 22101936 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf8 Ube2v1 21706008 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hist2h2ac Rnf8 21706008 biogrid exp, ortho Ube2n Rnf8 21706008 biogrid exp, ortho Kdm4a Rnf8 ortho Ube2d2 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Orc2 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf8 Usp16 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mre11a Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Sept7 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Homez Rnf8 ortho Pnma2 Rnf8 ortho Wrap53 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G Sept8 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad50 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G H2afx Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Xrcc5 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Atm Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnfrsf1a Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brca1 Rnf8 ortho G G G G G G G G G G G G G Rnf8 Bcl10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Chd4 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mgmt Rnf8 ortho G G Cep44 Rnf8 ortho Pcna Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf8 Tmem79 ortho G G G G G G G G G G G Jmjd1c Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Exosc2 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mcph1 Rnf8 ortho Rnf8 Chek2 ortho G G G G G G G G G G G G G G G G G G G G Ubc Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53bp1 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Herc2 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbfox2 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Blm Rnf8 ortho G G G G G G Ube2d1 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpsa Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf8 Ube2w ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc85b Rnf8 ortho Rxra Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2e1 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vcp Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf8 Ube2e2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf8 Ube2v2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf8 Sept3 ortho G G G G G G G G G G G G G G G G Ube2e3 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf8 Rnf8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdc1 Rnf8 ortho Rnf8 Mad1l1 ortho G G G Rnf8 Nbn ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnf Rnf8 ortho Rnf8 Yeats4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8VC56 O89023 affinity chromatography technology 22101936 physical association X 2 Q8VC56 O89023 enzymatic study 22101936 direct interaction X 2 Q8VC56 O89023 affinity chromatography technology 22101936 physical association X 2 Q8VC56 Q96AP0 anti tag coimmunoprecipitation 22101936 physical association X 2 Q8VC56 Q96AP0 anti tag coimmunoprecipitation 22101936 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality TPP1 RNF8 22101936,22101936 0415,0004 LC HIST2H2AC RNF8 21706008 0415 LC HIST2H2BE RNF8 21706008 0415 LC TPP1 RNF8 22101936,22101936 0415,0004 LC UBE2N RNF8 21706008 0096 LC RNF8 UBE2V1 21706008 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8VC56 P61089 RNF8 UBE2N 0.309 21706008 Q8VC56 Q64523 RNF8 HIST2H2AC 0.309 21706008 Q8VC56 Q64524 RNF8 HIST2H2BE 0.309 21706008 Q9CZY3 Q8VC56 UBE2V1 RNF8 0.309 21706008 Q8VC56 O89023 RNF8 TPP1 0.569 22101936