PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Prlr Fyn i2d exp G G G G Pde4a Fyn i2d exp Fyn Ubc 14531861 biogrid exp, ortho Dlg4 Fyn i2d exp, ortho G G G G Gnb2l1 Fyn i2d exp, ortho G G G G G Htr6 Fyn 17189269 mint exp, ortho Fyn Cblb 9890970 i2d,mint,intact exp, ortho G G G G G Fyn Bcar1 11181827 biogrid exp, ortho G G Dnm1 Fyn i2d exp, ortho G G G G G Med28 Fyn ortho G G G G G Fyn Tmem132a ortho Il2rb Fyn ortho G G Cse1l_predicted Fyn ortho G G G G G Traf6 Fyn ortho Cdk5 Fyn ortho G G G G G Fyn Rims2 ortho Fyn Akap6 ortho LOC687009 Fyn ortho Fyn Rps27 ortho Snx8_predicted Fyn ortho Protein Traip, RCG25586, isoform CRA_a, TRAF-interacting protein Fyn ortho G Psmd2 Fyn ortho G G G G G Protein Snx12 Fyn ortho G G G G G Fyn Psmc4 ortho G G G G G Wasf1 Fyn ortho Rps20 Fyn ortho Ccdc8 Fyn ortho G Fyn Prkcq ortho G G G G G Cd48 Fyn ortho G G G G G Cntnap1 Fyn ortho Shc1 Fyn ortho Fyn Slc24a1 ortho Map2 Fyn ortho G G G G Cd226_predicted Fyn ortho Snca Fyn ortho G G G G RGD1562292_predicted Fyn ortho Protein Sh3bp2 Fyn ortho Cdcp1_predicted Fyn ortho Rasa1 Fyn ortho G G G G G Fyn Cacna1f ortho Fyn Prpsap1 ortho G G G G G Gucy2e Fyn ortho G Fyn Prx ortho Fyn Sphk1 ortho G Protein Rpp38, RCG55882, Ribonuclease P/MRP 38 subunit (Human) Fyn ortho Sema5a Fyn ortho G G G G G Protein Sh3bp1 Fyn ortho G Cd44 Fyn ortho G G Gad1 Fyn ortho G G G Fyn Nmt1 ortho G G G G G Fyn Map3k12 ortho G G G G G RGD1563878_predicted Fyn ortho Nfasc Fyn ortho G G G Fyn Fcgr2 ortho G G G G Fyn Ptprs ortho G G G G G Plcg2 Fyn ortho G Fyn Abi1 ortho G G G G G Cd4 Fyn ortho G G G G G Ribosomal protein S6 kinase Fyn ortho G G G G G Hsp90ab1 Fyn ortho G G G G G Fyn Il1b ortho G G Hck Fyn ortho G G G G G Rps15a Fyn ortho G G G G G Cd36 Fyn ortho G G Dlgap3 Fyn ortho B29/Ig-beta/CD79b, Cd79b molecule, immunoglobulin-associated beta, Protein Cd79b Fyn ortho G Fyn Flot2 ortho G G G G G Fyn Cd55 ortho G Fyn Rtn4 ortho G G G G G Itpr1 Fyn ortho G G G G G Kcna4 Fyn ortho Pdss2 Fyn ortho G G G G Hnrnpk Fyn ortho LOC301114 Fyn ortho Integrin beta Fyn ortho G G Dlgap1 Fyn ortho G G G G Kpnb1 Fyn ortho G G G G G Cblc Fyn ortho Fyn Runx3 ortho G Protein Sos2 Fyn ortho G G G G G Snrpd1_predicted Fyn ortho Met Fyn ortho Fyn Mapre1 ortho G G G G G Fyn Xrcc1 ortho G G G G G Flnc Fyn ortho G G G Asap1 Fyn ortho G G G G Fyn Itgb4 ortho G G G Prdx6 Fyn ortho G G G G G Grin2a Fyn ortho Cyp4f3 Fyn ortho Mos Fyn ortho Ppp1r12b_predicted Fyn ortho G Hnrpr Fyn ortho G G G G G Rdx Fyn ortho G G G G G Sdc3 Fyn ortho G G G G G Slc25a5 Fyn ortho Protein Tmem181, RGD1566403 protein Fyn ortho Fyn Prkch ortho G G Rras Fyn ortho G G G G G Ptpn5 Fyn ortho G G G Fyn Fgr ortho G Tnfrsf1a Fyn ortho G G G G G Fyn Casp8 ortho G Add2 Fyn ortho G Was_predicted Fyn ortho Protein Pax3 Fyn ortho Pde4d Fyn ortho G G G G Brpf3_predicted Fyn ortho Fyn Sh3bp5 ortho G G G G G Fyn Gtf3a ortho Fyn Flot1 ortho G G G G G Fyn Sh3kbp1 ortho G G G G G Fyn RegR ortho Rin3_predicted Fyn ortho G G Lck Fyn ortho G G G G G Cntfr Fyn ortho G G G G G RGD1304792_predicted Fyn ortho Atp5b Fyn ortho G G G G G Nck1 Fyn ortho G G G G G Fyn Fas ortho Fyn Ikbkg ortho Fyn Sf3b4 ortho G G G G G Prkce Fyn ortho G G G G G Ltbp2 Fyn ortho Fyn Mcam ortho G G G G G Fyn Hcn4 ortho UPF0415 protein C7orf25 homolog Fyn ortho G G G G G Fyn Ptprf ortho G G G G Fyn Wnk1 ortho G G G G G Suv39h1 Fyn ortho G G G G G Slc16a1 Fyn ortho G G G G G Srpk2_predicted Fyn ortho G G G G G Epha3 Fyn ortho RGD1560634_predicted Fyn ortho Cd3d Fyn ortho Map4k1_predicted Fyn ortho G Oxsr1_predicted Fyn ortho G G G G G Dlgap2 Fyn ortho Protein Arhgap32 Fyn ortho G G G G Fyn Jup ortho G G G G G Cnn1 Fyn ortho Enabled homolog (Drosophila), Protein Enah Fyn ortho G G G G G Mag Fyn ortho G G G G G Fyn Mapk13 ortho G Havcr2 Fyn ortho Ptpn11 Fyn ortho G G G G G Grin2b Fyn ortho Chrna7 Fyn ortho G G G G G RGD1564487_predicted Fyn ortho Fyn Cct5 ortho G G G G G Myh9 Fyn ortho G G G G G Ywhab Fyn ortho G G G G G Fyn Pxn ortho G G G G G Insr Fyn ortho G G G G G Fyn Khdrbs1 ortho G G G G G Tubby-like protein Fyn ortho Cd8a Fyn ortho Fyn Trim39 ortho Neural cell expressed, developmentally down-regulated 9, Protein Nedd9, RCG44232, isoform CRA_b Fyn ortho G G G G G LOC686765 Fyn ortho G G G G G Ptpra Fyn ortho G G G G Fyn Atxn1 ortho G Rbfox2 Fyn ortho G G G G G Fyn Src ortho G G G G Kcna5 Fyn ortho RGD1563607_predicted Fyn ortho Hras Fyn ortho G G G G G Mknk1 Fyn ortho G G G G G Amd1 Fyn ortho G G G G G Irs1 Fyn ortho Cckbr Fyn ortho G Cdc27 Fyn ortho Fyn Pik3r2 ortho G G G G G Dok4_predicted Fyn ortho Fyn Cdh1 ortho G Dnm3 Fyn ortho G G G G G Fyn RGD1306344 ortho Sp1 Fyn ortho G G G G G Raf1 Fyn ortho G G G G G Cnn3 Fyn ortho G G G G G Fyn Erythrocyte protein band 4.1-like 3, isoform CRA_d, Protein Epb41l3, Type II brain 4.1 ortho G G G G G Map4k4_predicted Fyn ortho G G G G G Flna_predicted Fyn ortho G G G G G Il7r_predicted Fyn ortho Cav1 Fyn ortho G G G G G Eif2s3 Fyn ortho G G G G G Fyn F2rl2 ortho G DEAD (Asp-Glu-Ala-Asp) box polypeptide 41, Protein Ddx41, RCG24134 Fyn ortho Protein Cd19 Fyn ortho Cd3z Fyn ortho G MGC125004 Fyn ortho Kdm1a Fyn ortho G G G G G Nkx2-1 Fyn ortho G G G Fyn Stk17b ortho G G Pre-mRNA processing factor 8, isoform CRA_a, Protein Prpf8 Fyn ortho G G G G G Ccnl2 Fyn ortho G G G G G Fyn Arhgef11 ortho Fasn Fyn ortho G G G G G Grb10 Fyn ortho G G G G G Synj2 Fyn ortho Histone H2B Fyn ortho Fyn Ctnnb1 ortho G G G G G Dab2 Fyn ortho G G G G G Fyn Wipf1 ortho G G G G G Lyn Fyn ortho G G Fyn Snx17 ortho G G G G G Lat Fyn ortho G Protein Clnk Fyn ortho Fyn Fam110a ortho Protein Il3ra Fyn ortho G Kdr Fyn ortho G G G G G Yes1 Fyn ortho Stat3 Fyn ortho G G G G G Fyn Socs1 ortho Pink1_predicted Fyn ortho G G G G G Protein Tnfrsf9, Similar to T-cell antigen 4-1BB-mouse, isoform CRA_a, Tumor necrosis factor receptor superfamily, member 9 Fyn ortho Protein Cct7, RCG55994, isoform CRA_c Fyn ortho G G G G G Fyn Shroom2 ortho G G G G G RGD1563421_predicted Fyn ortho Prkcd Fyn ortho G G G G G Celsr3 Fyn ortho G G G G G Fyn Hexa ortho G G G G G Fyn Adam15 ortho G G G G G Fyn LOC683746 ortho Slc25a3 Fyn ortho G G G G G Gpr45_predicted Fyn ortho Grb2 Fyn ortho G G G G G Fyn Ddx1 ortho G G G G G Cma1 Fyn ortho G Fyn Crk ortho G G G G G Fyn Csf2rb ortho G G Stk4_predicted Fyn ortho G G G G G Fyn Orc1 ortho Fyn Cct3 ortho G G G G G Thoc4 Fyn ortho G G G G G E2f7 Fyn ortho Sec61a1 Fyn ortho G G G G G Dlgap4 Fyn ortho G G G G G Ywhaq Fyn ortho G G G G G Fyn C6 ortho Fyn Unc119 ortho G G G G G Uhrf2_predicted Fyn ortho G G G G G Protein Sos1, Son of sevenless homolog 1 (Drosophila) Fyn ortho G G G G G Skap1 Fyn ortho Ywhae Fyn ortho G G G G G RGD1307595_predicted Fyn ortho G G G G G Ash1l_predicted Fyn ortho G G G G G Protein Wnk2 Fyn ortho G G G Tdrd1_predicted Fyn ortho Protein Cbl Fyn ortho Pecam1 Fyn ortho G G Fyn Protein Sphk2, RCG53912, isoform CRA_a, Sphingosine kinase 2 ortho G G G G G Protein Son Fyn ortho G G G G G Cdk1 Fyn ortho G Vav1 Fyn ortho G Protein Ckap5 Fyn ortho G G G G G Fyn Skap2 ortho G G G G G Prkcz Fyn ortho G G G Sema7a_predicted Fyn ortho Protein Pax7 Fyn ortho Kctd5 Fyn ortho Fyn Hematopoietic cell specific Lyn substrate 1, Protein Hcls1, RCG52681 ortho Gpr2_predicted Fyn ortho Fyn Syk ortho G Protein Med14 Fyn ortho Tnf Fyn ortho RGD1307832_predicted Fyn ortho G G G G G Hsp90aa1 Fyn ortho Ncam1 Fyn ortho G G G ifitm3 Fyn ortho G G G G G LOC317380 Fyn ortho Fyn Npvf ortho G G G Srpk1 Fyn ortho G G G G G Fyn Tsnax ortho G G G G G LOC498335 Fyn ortho G Dhx9_predicted Fyn ortho G G G G G Fyn Hcn2 ortho G G G G G Eps15 Fyn ortho G G G G G Fyn Pik3r3 ortho G Brca2 Fyn ortho Ptprz1 Fyn ortho G G G G Cltc Fyn ortho G G G G G Plcg1 Fyn ortho G G G G G Gnb1 Fyn ortho G G G G G Csk Fyn ortho G G G G G Fyn Ctla4 ortho Fyn Cdc37 ortho G G G G G Frk Fyn ortho Cd2ap Fyn ortho Fyn Pik3r1 ortho G Fyn Nphs1 ortho Brd8 Fyn ortho G G G G G Cckar Fyn ortho Fyn Lrwd1 ortho G G G G G Fyn Xrcc5 ortho G G G LOC687711 Fyn ortho G G G G G Fyn trp6A ortho Ptk2 Fyn ortho G G G G G Tuba4a Fyn ortho G G G G G Protein Tmem185a Fyn ortho G G G G Klrk1 Fyn ortho G G G G G Slc25a11 Fyn ortho G G G G G Galr3 Fyn ortho Scarf2_predicted Fyn ortho G Fyn Rpl10 ortho Tyrosine-protein phosphatase non-receptor type Fyn ortho G Ctnnd1_predicted Fyn ortho G G G G G Ms4a1_predicted Fyn ortho Protein Pdia2 Fyn ortho Tnk2 Fyn ortho G G G G G Ptpre Fyn ortho G G Fyn Cd3g ortho G G Sh2d1a Fyn ortho Tcp1 Fyn ortho G G G G G Nckipsd_predicted Fyn ortho Dok3 Fyn ortho Fyn Ythdc1 ortho G G G G G Fyn SLP76 ortho G Lymphotoxin B receptor, Lymphotoxin beta receptor (TNFR superfamily, member 3), Protein Ltbr Fyn ortho G G G G G Fyn Cd244 ortho Dlx4_predicted Fyn ortho Sit1 Fyn ortho Dok1 Fyn ortho Plaur Fyn ortho G Itch Fyn ortho Fyn Ntrk2 ortho G G G Cd2 Fyn ortho Fyn Cntn1 ortho G G G Gstz1 Fyn ortho G G G G Protein Vav2 Fyn ortho G Grin1 Fyn ortho G G G Jak2 Fyn ortho G Fyn Rims1 ortho Fyn Mepe ortho G Fyn Trpv4 ortho Ptp4a3_predicted Fyn ortho G G G G Atp1a1 Fyn ortho G G G G G Fyn Pdcd6ip ortho G G G G G Faslg Fyn ortho G G Rpl18a Fyn ortho G G G G G Sdhb Fyn ortho G G G G G Hoxc8 Fyn ortho Dnaja1 Fyn ortho G G G G G Thy1 Fyn ortho G G G G G Fyn Shank3 ortho G G G G Cast Fyn ortho G G G G G Stip1 Fyn ortho G G G G G Sfxn4_predicted Fyn ortho G G G G Protein Gpr63, RCG54778 Fyn ortho Cnr1 Fyn ortho G G G G Ankrd12_predicted Fyn ortho Fyn Gabbr1 ortho G G G G G Fyn Sh2b2 ortho Tyro3 Fyn ortho G G G RGD1563523_predicted Fyn ortho Protein Ndfip2 Fyn ortho G G G G G Casp3 Fyn ortho G G Nr3c1 Fyn ortho G G G G G Fibroblast growth factor receptor Fyn ortho G G G G G Fyn Tnnt1 ortho Eno1 Fyn ortho G G G G G Pold1 Fyn ortho G Atad3 Fyn ortho G G G G G Tyrosine-protein kinase Fyn ortho G Ptprc Fyn ortho G G Tom1l1 Fyn ortho Abl2_mapped Fyn ortho G G G G G Rps11 Fyn ortho G G G G G Protein Bcl3, RCG53730 Fyn ortho Protein G3bp1 Fyn ortho G G G G G LOC100909609 Fyn ortho Protein Dag1 Fyn ortho G G G G G Rplp1 Fyn ortho Hcrtr2 Fyn ortho G G G G Fyn Xpo1 ortho G G G G G Tsks Fyn ortho Fyn Dcc ortho Mapk7 Fyn ortho G G G G G Pdgfrb Fyn ortho Fyn Pak2 ortho G G G G G Fyn Dcbld2 ortho Aire_predicted Fyn ortho Fyn Fyn ortho G G G G G Nek8 Fyn ortho GRB2-related adaptor protein, Protein Grap Fyn ortho Ptk2b Fyn ortho G Efs_predicted Fyn ortho G G G Snx3 Fyn ortho G G G G G Kcna2 Fyn ortho G Fyn Pag1 ortho Ick Fyn ortho G G G G G Protein Pkd1 Fyn ortho Fyn Fcer2a ortho Limk1 Fyn ortho ATP-binding cassette, sub-family E (OABP), member 1, Protein Abce1 Fyn ortho G G G G G Dusp15_predicted Fyn ortho Nr5a1 Fyn ortho Raver1 Fyn ortho G Pld2 Fyn ortho G G G Mybbp1a Fyn ortho G G G G G Cd300lb Fyn ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q62844 Q8K4S7 - 12231245 - X 2 Q62844 - 11943848 - X 2 Q62844 - 7935483 - X 2 P31016 Q62844 - 9892651 - X 2 P31016 Q62844 - 9892651 - X 2 Q62844 - 8761480 - X 2 Q62844 - 8402898 - X 2 Q62844 Q63767 affinity chromatography technology 11181827 physical association X 2 Q62844 Q63767 enzymatic study 11181827 direct interaction X 2 Q63429 Q62844 affinity chromatography technology 14531861 physical association X 2 Q62844 coimmunoprecipitation 9079653 association C 3 Q62844 coimmunoprecipitation 10708762 association C 4 Q62844 Q8K4S7 anti bait coimmunoprecipitation 9890970 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Fyn Cblb MI:0096(pull down)|MI:0096(pull down) 9890970 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_186957|MINT_71837 prey|prey bait|bait Htr6 Fyn MI:0018(two hybrid) 10 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) MI:0471(mint) MINT_71836 bait prey Fyn Bcar1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11181827 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_335011|BIOGRID_337629 prey|bait bait|prey Fyn Ubc MI:0004(affinity chromatography technology) 14531861 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334680 bait prey

PPI - HINT Gene A Gene B PMID Method Quality DLG4 FYN 9892651,9892651 0019,0004 LC RACK1 FYN 11943848,11943848,11943848 0018,0047,0019 LC FYN BCAR1 11181827,11181827 0415,0004 LC FYN CBLB 12231245,12231245 0019,0045 LC DNM1 FYN 8402898 0004 LC DLG4 FYN 9892651,9892651 0019,0004 LC HTR6 FYN 17189269 0006 LC PDE4A FYN 8761480 0004 LC FYN UBC 14531861 0004 LC FYN BCAR1 11181827,11181827 0415,0004 LC FYN CBLB 9890970 0006 LC