PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus App Senp2 ortho G G G G G G G Senp2 Cdk5rap2 ortho G G G G G G G Nup107 Senp2 ortho Sumo3 Senp2 ortho G G G G G G G Syne4 Senp2 ortho Axin1 Senp2 ortho G G G G G G G Sumo2 Senp2 ortho G G G G G G G Elavl4 Senp2 ortho G G G G G G G Hnrnpk Senp2 ortho Protein Rangap1, RCG59652, isoform CRA_b Senp2 ortho G G G G G G G Ikbkg Senp2 ortho Fundc1 Senp2 ortho G G G G G G G LOC100361515 Senp2 ortho Fzr1_predicted Senp2 ortho G G G G G G G Nup153 Senp2 ortho G G G G G G G Tmem17 Senp2 ortho Trim63 Senp2 ortho Smad2 Senp2 ortho G G G G G G G LOC293551 Senp2 ortho G G G G G G G Nup43 Senp2 ortho G G G G G G G LOC688109 Senp2 ortho Mdm2_predicted Senp2 ortho G G G G Sumo1 Senp2 ortho G G G G G G G Tpd52_predicted Senp2 ortho Tmem216 Senp2 ortho G G G G G G G Daxx Senp2 ortho G G G G G G G Agtrap Senp2 ortho G G G G Hipk2_predicted Senp2 ortho G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9EQE1 P55854 pull down 17428805 direct interaction X 2 Q9EQE1 P55854 enzymatic study 17428805 direct interaction X 2 Q9EQE1 P61956-2 pull down 17428805 direct interaction X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9EQE1 P55854 SENP2 SUMO3 0.523 17428805 Q9EQE1 P61956 SENP2 SUMO2 0.309 17428805