PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Grb2 Flt3 i2d exp Erbb2 Grb2 i2d exp Abl2_mapped Grb2 8663064 biogrid exp G G G G G G G Protein Irs2, RCG43183 Grb2 12960006 biogrid exp, ortho G G G G G G G G Ptpn11 Grb2 21946312 mint,intact exp, ortho G G G G G G G G Synj2 Grb2 i2d exp, ortho Grb2 Met 12218049,7798267 biogrid,mint,intact exp, ortho G Ntrk1 Grb2 10748052 mint,intact exp, ortho Irs1 Grb2 12446583,12960006 biogrid,mint,intact exp, ortho Grb2 Shc1 12446583,9722539,9918770,12167719 biogrid,mint,intact exp, ortho Plcg1 Grb2 9281317 mint,intact exp, ortho G G G G G G G G Hnrnpk Grb2 16518874 intact exp, ortho Protein Cbl Grb2 9918770 biogrid exp, ortho Grb2 Ubc 22871113 biogrid exp, ortho Grb2 Wipf1 16990791 mint,intact exp, ortho G G G G G G G G Dnm1 Grb2 17437541 mint,intact exp, ortho G G G G G G G G Protein Cct7, RCG55994, isoform CRA_c Grb2 ortho G G G G G G G G Grb2 Rpl24 ortho G G G G G G G G Brpf3_predicted Grb2 ortho Protein Srgap3 Grb2 ortho Grb2 Nono ortho G G G G G G G G Brcc3 Grb2 ortho G G G G G G G G Grb2 Myrip ortho Grb2 Sh2b1 ortho G G G G G Cul3 Grb2 ortho G G G G G G G G RGD1306881_predicted Grb2 ortho Grb2 Pon2 ortho G G G G G G G G Protein Pnma5, RCG19945 Grb2 ortho Rab13 Grb2 ortho G G G G G G G G Mapk7 Grb2 ortho G G G G G G G G Casp2 Grb2 ortho G G G G G G G G Zmym5 Grb2 ortho Grb2 Interleukin 2 receptor, gamma, Interleukin 2 receptor, gamma (Severe combined immunodeficiency), isoform CRA_a, Protein Il2rg ortho G G G G Grb2 Lat2 ortho Csf3r_predicted Grb2 ortho Protein Tab1, RCG59826 Grb2 ortho G G G G G G G G Zfpn1a3_predicted Grb2 ortho Grb2 Actr2 ortho G G G G G G G G p27Kip1 Grb2 ortho G G G G G G G G Ptprc Grb2 ortho G G G G Cfl1 Grb2 ortho G G G G G G G G Cse1l_predicted Grb2 ortho G G G G G G G G Grb2 Myh11 ortho G G G G G G G G Protein Limch1 Grb2 ortho G G G G G G G Grb2 Khdrbs1 ortho G G G G G G G G Grb2 Mfap4 ortho Grb2 Pik3r2 ortho G G G G G G G G Rpl27a Grb2 ortho G G G G G G G G Rps8 Grb2 ortho G G G G G G G G Rps16 Grb2 ortho G G G G G G G G Pitrm1_predicted Grb2 ortho Protein Uaca Grb2 ortho G G G G G G G G Grb2 Bcar1 ortho G G G G G Rps29 Grb2 ortho Grb2 Adam15 ortho G G G G G G G G Protein Snx12 Grb2 ortho G G G G G G G G Grb2 Spryd4 ortho G G G G G G G G Hist1h4b, Hist1h4m, Hist4h4 Grb2 ortho G G G G G Grb2 Lck ortho G G G G G G G G Protein Lrrk1 Grb2 ortho Akt1 Grb2 ortho G G G G G G G G Arhgef7 Grb2 ortho G G G G G G G G Rapsn_predicted Grb2 ortho Cd2ap Grb2 ortho Protein Gltscr1 Grb2 ortho Grb2 Epor ortho G G G G G G G Il6st Grb2 ortho G G G G G G G RGD1304623_predicted Grb2 ortho G G G G G G G G Dnaja2 Grb2 ortho G G G G G G G G LOC100361515 Grb2 ortho Polr1b Grb2 ortho Aire_predicted Grb2 ortho Cdc42bpg_predicted Grb2 ortho Grb2 Psme1 ortho G G G G G G G G Ar Grb2 ortho G G G G G G G Ezr Grb2 ortho G G G G G G G G Ugdh Grb2 ortho G G G G G G G G Nefh Grb2 ortho G G G G Nckipsd_predicted Grb2 ortho Protein Plxnb1 Grb2 ortho G G G G G G Grb2 Actin-like 6A, Protein Actl6a ortho G G G G G G G G Tfap2a Grb2 ortho Grb2 Rnf10 ortho G G G G G G G G Lalba Grb2 ortho Grb2 Pnrc1 ortho G G G G G G G G Bat4 Grb2 ortho G G G G G G G G Grb2 Dok1 ortho Protein Wipf2 Grb2 ortho Tyr_mapped Grb2 ortho Grb2 Rps27 ortho Grb2 C6 ortho Grb2 Ppp3ca ortho G G G G G G G G Pkm Grb2 ortho Rpl5 Grb2 ortho Grb2 Eif3d ortho G G G G G G G G Vgf Grb2 ortho G G G G Grb2 Wdr6 ortho G G G G G G G G Grb2 Krt17 ortho RGD1307832_predicted Grb2 ortho G G G G G G G G Protein Hunk Grb2 ortho G G G G Cltc Grb2 ortho G G G G G G G G Celsr3 Grb2 ortho G G G G G G Grb2 Ik ortho G G G G G G G G Protein Pik3cg Grb2 ortho Grb2 Itpr3 ortho G G G Smarca5_predicted Grb2 ortho Grb2 Kcnma1 ortho G G G G G Protein LOC100365556 Grb2 ortho Pdcd6_predicted Grb2 ortho G G G G G G G G Tom1l1 Grb2 ortho Grb2 Pacsin1 ortho G G G G G Nkd2_predicted Grb2 ortho Grb2 Shank3 ortho G G G G G G Map1a Grb2 ortho G G G G G G G G Grb2 Hibch ortho G G G G G G G G Rpl4 Grb2 ortho G G G G G G G G RGD1561064_predicted Grb2 ortho G G G G G Grb2 Protein Rpp38, RCG55882, Ribonuclease P/MRP 38 subunit (Human) ortho Grb2 Cct5 ortho G G G G G G G G Grb2 Cct2 ortho G G G G G G G G Grb2 Krt34 ortho Shbg Grb2 ortho Rbp4 Grb2 ortho G G G G G G G Zfp521_predicted Grb2 ortho Grb2 Mapk1 ortho G G G G G G G G Psmd11 Grb2 ortho G G G G G G G G Grb2 Smu1 ortho G G G G G G G G Grb2 Ab2-292, Protein Sec62 ortho G G G G G G G G Grb2 Itgb4 ortho G G G G Htt Grb2 ortho G G G G G G G Bin1 Grb2 ortho G G G G G G G Rps15a Grb2 ortho G G G G G G G G Grb2 Actn4 ortho G G G G G G G G Grb2 Homez ortho RGD1563888_predicted Grb2 ortho G G G G G G G Grb2 Abi1 ortho G G G G G G G G Protein Sh2d5, RCG31450 Grb2 ortho Cox6a1 Grb2 ortho G G G G G G G G Ap2s1 Grb2 ortho G G G G G G G G Nck1 Grb2 ortho G G G G G G G G Grb2 Map4k3 ortho G G G G G G G G Grb2 Ka30 ortho Grb2 Atp5o ortho G G G G G G G G Grb2 Hspd1 ortho G G G G G G G G Grb2 Pld1 ortho G G G G G G G Grb2 Actg1 ortho G G G G G G G G Grb2 Erbb3 ortho G LOC687424 Grb2 ortho G G G G G G G G Grb2 Dut ortho G G G G G G G G Grb2 MGC125004 ortho Grb2 RegR ortho Fibroblast growth factor receptor Grb2 ortho G G G G G G G G Grb2 Map1lc3a ortho G G G G G G G G Grb2 Scin ortho Lmna Grb2 ortho G G G G G G G G Elk3_predicted Grb2 ortho G G G G G G G G Grb2 Anxa2 ortho G G G G G G G G Cct8_predicted Grb2 ortho G G G G G G G G Grb2 Nexn ortho RGD1308918_predicted Grb2 ortho G G G G G G G G Grb2 Wipf3 ortho G G G G Was_predicted Grb2 ortho Hras Grb2 ortho G G G G G G G G Grb2 Protein Rgl2, RAB2, member RAS oncogene family-like, Ral guanine nucleotide dissociation stimulator-like 2 ortho G G G G G G G Grb2 Smad3 ortho G G G Protein Snta1, Snta1 protein Grb2 ortho G G G G G Tgfbr2 Grb2 ortho Protein Vps9d1, RGD1565149 protein Grb2 ortho G G G G G G G G Smarcc1_predicted Grb2 ortho G G G G G G G G Grb2 Cuta ortho G G G G G G G G Protein Helz Grb2 ortho G G G G G G G G Ssbp1 Grb2 ortho G G G G G G G G Grb2 Nr1h4 ortho G G Grb2 Pik3r3 ortho G Tjp1_predicted Grb2 ortho G G G G G G G G Arpc3_predicted Grb2 ortho G G G G G G G G Grb2 Kb23 ortho Protein Synm, RCG24674, isoform CRA_b Grb2 ortho G G G G G G G G Ahsg Grb2 ortho G G G G Hspb1 Grb2 ortho G G G G G G G Ctage5 Grb2 ortho G G G G G G G G Dok3 Grb2 ortho Shc2 Grb2 ortho G Grb2 Shank2 ortho G G G G G G G Serpinh1 Grb2 ortho G G G G G G G Ap2b1 Grb2 ortho G G G G G G G G Grb2 Pag1 ortho Grb2 Clpx ortho G G G G G G G G Rasa1 Grb2 ortho G G G G G G G Grb2 LIM domain only 2, Protein Lmo2 ortho Protein Ss18 Grb2 ortho G G G G G G G G RGD1310481_predicted Grb2 ortho G G G G G G G G Grb2 Med28 ortho G G G G G G G G Kcnh7 Grb2 ortho Protein Med14 Grb2 ortho Tpx2_predicted Grb2 ortho Bicd1_predicted Grb2 ortho Dhx9_predicted Grb2 ortho G G G G G G G G Arpc4_predicted Grb2 ortho G G G G G G G G RGD1562795_predicted Grb2 ortho Tyrosine-protein kinase Grb2 ortho G G G G Grb2 Lepr ortho G Chrm4 Grb2 ortho Protein Kb15, Type II keratin Kb15 Grb2 ortho Grb2 Prap1 ortho Iqgap1_predicted Grb2 ortho G G G G G G G G Protein Tal2, RCG32020 Grb2 ortho Grb2 Rit2 ortho G G G G G Grb2 Prrc2a ortho G G G G G G G G Plcg2 Grb2 ortho G Dlx4_predicted Grb2 ortho Pdgfra Grb2 ortho G G G G G G G Grb2 Protein Snx7, RCG28719, Sorting nexin 7 ortho Protein Srp14, RCG26543, isoform CRA_b, Signal recognition particle 14 Grb2 ortho G G G G G G G G Grb2 Krt1 ortho Ybx1 Grb2 ortho Gc Grb2 ortho G G G G G G G Grb2 Pdap1 ortho G G G G G G G G Grb2 Grb2 ortho G G G G G G G G Pex13_predicted Grb2 ortho G G G G G G G G Grb2 Ada ortho G G Grb2 Cdc27 ortho Rab6b_predicted Grb2 ortho G G G G G Il2rb Grb2 ortho G G G G Gstm2 Grb2 ortho G G G G G G G G Ipo7_predicted Grb2 ortho G G G G G G G G Grb2 Rims1 ortho Uqcc2 Grb2 ortho G G G G G G G G Grb2 Akap2 ortho Il7r_predicted Grb2 ortho Grb2 Nfasc ortho G G G G Grb2 Myh10 ortho G G G G G G Nfe2l2 Grb2 ortho G G G G G G G G Grb2 Cd164 ortho G G G G G G G G Grb2 Ager ortho Grb2 Celf2 ortho G Grb2 Fliih ortho G G G G G G G G Grb2 Asap1 ortho G G G G G G G Ppp5c Grb2 ortho G G G G G G G Protein Ruvbl2, RuvB-like 2 (E. coli) Grb2 ortho G G G G G G G G Hoxc8 Grb2 ortho Adrb2 Grb2 ortho G Grb2 Dlgap3 ortho Grb2 Fubp3 ortho Poly(A) binding protein, nuclear 1, isoform CRA_a, Protein Pabpn1 Grb2 ortho G G G G G G G G Grb2 Snapc3 ortho Grb2 Nfyb ortho Grb2 Eukaryotic translation initiation factor 4A1, Eukaryotic translation initiation factor 4A1, isoform CRA_c, Protein Eif4a1 ortho Npm1 Grb2 ortho Grb2 Src ortho G G G G G Prkar1a Grb2 ortho G G G G G G G G Grb2 Synj1 ortho G G G G G G G G Grb2 Golga2 ortho G G G G G G G G Grb2 Nr1h2 ortho G G G G G G G G Rpl3 Grb2 ortho G G G G G G G G Lat Grb2 ortho G G Tsks Grb2 ortho Grb2 Gmfb ortho G G G G G G G G Grb2 Tp63 ortho Grb2 Syk ortho G G G Grb2 Krt14 ortho Protein Sos2 Grb2 ortho G G G G G G G G Protein LOC100365676, Similar to Butyrate-induced transcript 1 (Predicted) Grb2 ortho G G G G G G G G Grb2 Tnk2 ortho G G G G G G Vav1 Grb2 ortho G ELK1, Potassium voltage-gated channel subfamily H member 8, RCG42928 Grb2 ortho G Grb2 Eps15 ortho G G G G G G G G Grb2 Nif3l1 ortho Protein Pcdhb10, RCG49561 Grb2 ortho Kdr Grb2 ortho G G G G G G G G Cd59 Grb2 ortho G G G G G G G G Grb2 Tcn2 ortho G G G G G G G G Grb2 Hnrnpf ortho G G G G G G G Grb2 Git1 ortho G G G G G G G G Ap2a2 Grb2 ortho G G G G G G G G Grb2 Dlgap2 ortho Eno1 Grb2 ortho G G G G G G G G Grb2 Ptpra ortho G G G G G G Drd4 Grb2 ortho Ngfr Grb2 ortho Grb2 Cd3z ortho G G Mtco1 Grb2 ortho G G G G G G G G Grb2 Cntnap1 ortho Atp5a1 Grb2 ortho G G G G G G G G Clu Grb2 ortho G G G G G G G G Grb2 Dld ortho G G G G G G G G Grb2 Pdgfrb ortho Glul Grb2 ortho G G G G G G G G Protein Il3ra Grb2 ortho G G G Anxa6 Grb2 ortho G G G G G G G G Grb2 Gabbr1 ortho G G G G G G G G Rps23 Grb2 ortho G G G G G G G G Map4k4_predicted Grb2 ortho G G G G G G G G Protein Ppp6r3 Grb2 ortho G G G G G G G G Protein Ppp2r3a, Protein phosphatase 2 (Formerly 2A), regulatory subunit B'', alpha, isoform CRA_a Grb2 ortho Gad1 Grb2 ortho G G G Grb2 Map2k5 ortho G G G G G G G G Grb2 Pawr ortho G G Rpl7 Grb2 ortho G G G G G G G G Grb2 Specc1l ortho Grb2 Actr3 ortho Grb2 Erbb4 ortho Rps9 Grb2 ortho Pfdn5_predicted Grb2 ortho G G G G G G G G Protein Gareml Grb2 ortho Mtnd4 Grb2 ortho Protein Pax3 Grb2 ortho Ywhag Grb2 ortho G G G G G G G G Grb2 Alas2 ortho G Apoh Grb2 ortho G G G G G Grb2 Nasp ortho G G G G G G G G Vcam1 Grb2 ortho Grb2 Hsd17b4 ortho G G G G G G G G Grb2 Map4 ortho G G G G G G G G Sh3pxd2a_predicted Grb2 ortho Grb2 Actc1 ortho Gstz1 Grb2 ortho G G G G G G G Pik3r4 Grb2 ortho G G G G G G G G Rlc-a Grb2 ortho G G G G G G G G Grb2 Arl6ip4 ortho G G G G G G G G Grb2 Cct4 ortho G G G G G G G G Hsp90ab1 Grb2 ortho G G G G G G G G LOC688297 Grb2 ortho G G G G G G G G Grb2 Ubr4 ortho G G G G G G G G Bclaf1 Grb2 ortho G G Protein Traip, RCG25586, isoform CRA_a, TRAF-interacting protein Grb2 ortho G Camk2d Grb2 ortho G G G G G G G G Protein Ly9 Grb2 ortho Mapk10 Grb2 ortho Grb2 SLP76 ortho G Grb2 Ywhaz ortho G G G G G G G G Grb2 Arhgef11 ortho Grb2 Dbn1 ortho G G G G RGD1559884_predicted Grb2 ortho Grb2 Arhgap17 ortho G G G G G G G G Dync1h1 Grb2 ortho G G G G G G G G Psap Grb2 ortho G G G G G G G G Rps25 Grb2 ortho Gstk1 Grb2 ortho G G G G G G G G Cd22_predicted Grb2 ortho Protein Arid2 Grb2 ortho Grb2 Akap6 ortho Smarcd2 Grb2 ortho G G G G G Grb2 Kcnq1 ortho G G St5_predicted Grb2 ortho G G G G G G G G Grb2 Sf3b4 ortho G G G G G G G G Lnx1_predicted Grb2 ortho G Alb Grb2 ortho G G G G G G G Scarf2_predicted Grb2 ortho G G G Grb2 Mta1 ortho G Grb2 Ros1 ortho G Grb2 Skap2 ortho G G G G G G G G Hspa1l Grb2 ortho Snrnp200 Grb2 ortho G G G G G G G G C1r Grb2 ortho G G G G Grb2 Hsp90aa1 ortho Flnb_predicted Grb2 ortho Grb2 GRB2-related adaptor protein, Protein Grap ortho Grb2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5, Ddx5, Protein Ddx5 ortho G G G G G G G G Grb2 Dnm3 ortho G G G G G G G G Ppp1ca Grb2 ortho G G G G G G G G Grb2 Slc25a4 ortho G G G G G G G G Grb2 Hgs ortho G G G G G G G G Smarcd1_predicted Grb2 ortho G G G Tsc2 Grb2 ortho G G G G G G G G Grb2 Snx3 ortho G G G G G G G G Rpl27 Grb2 ortho G G G G G G G G Grb2 Tufm ortho G G G G G G G G Grb2 Tubby-like protein ortho Grb2 Ajuba ortho G G G G Insr Grb2 ortho G G G G G G G G Grb2 Krt81 ortho Protein Rbbp6, Retinoblastoma binding protein 6, isoform CRA_a Grb2 ortho G G Hnrnpa2b1 Grb2 ortho G G G G G G G G Pnlip Grb2 ortho G G Ephb1 Grb2 ortho Stat5b Grb2 ortho G Grb2 Ptprn2 ortho G G G G G Grb2 Grip2 ortho eplin Grb2 ortho G G G G G G G G Grb2 Stambp ortho G G G G G G G G Emc7 Grb2 ortho G G G G G G G G Grb2 Id4 ortho G G G G Sema7a_predicted Grb2 ortho B2m Grb2 ortho G G G G G G G G Crybb3 Grb2 ortho G G Grb2 Dlgap1 ortho G G G G G G Sdhb Grb2 ortho G G G G G G G G Vcp Grb2 ortho G G G G G G G G Gfap Grb2 ortho G G G G G G Grb2 Serine hydroxymethyltransferase ortho G G G G Grb2 Sit1 ortho Brca2 Grb2 ortho Protein Tcerg1 Grb2 ortho G G G G G G G G Grb2 Grb7 ortho G G G Grb2 Dlst ortho G G G G G G G G Grb2 Babam1 ortho G G G G G G G G Actb Grb2 ortho RGD1563878_predicted Grb2 ortho Usp6nl_predicted Grb2 ortho Grb2 Tubb5 ortho G G G G G G G G Grb2 Krt7 ortho G G Ppp3cb Grb2 ortho G G G G G G G G Grb2 Eef1g ortho G G G G G G G G Gja1 Grb2 ortho G G G G G G G G Grb2 Grwd1 ortho G G G G G G G G Grb2 Protein Stard10, START domain containing 10, isoform CRA_b, StAR-related lipid transfer (START) domain containing 10 ortho G G G G G G G Grb2 Dctn2 ortho G G G G G G G G Grb2 Il5ra ortho Grb2 Dlgap4 ortho G G G G G G Grb2 Brd8 ortho G G G G G G G Eef1a1 Grb2 ortho G G G G G G G G Phactr2 Grb2 ortho Grb2 Mepe ortho G Grb2 Sp1 ortho G G G G G G G G Grb2 Krt4 ortho G Grb2 Krt18 ortho G G G G G G Grb2 Nxph3 ortho G Protein Zfp637, RCG30169, isoform CRA_b, Zfp637 protein Grb2 ortho G G G G G G G G Grb2 Myh9 ortho G G G G G G G G Grb2 Cblb ortho G G G G G G G LOC100361758 Grb2 ortho G G G G G Rras Grb2 ortho G G G G G G G G Sell Grb2 ortho G G Impdh2 Grb2 ortho G G G G G G G G Grb2 Protein Krt36, Type I hair keratin KA31 ortho Esr1 Grb2 ortho Grb2 Enpp3 ortho G G G LOC100909609 Grb2 ortho Stk32c_predicted Grb2 ortho G G G G Grb2 Rac1 ortho G G G G G G G G Protein Shc4 Grb2 ortho Protein Spry4, RCG49355 Grb2 ortho Grb2 Actn1 ortho G G G G G G G G Grb2 Sirpa ortho G G G G G G G G Shc3 Grb2 ortho Grb2 Pik3r1 ortho G Grb2 Coronin ortho G G G G G G G G Protein Cnot1, RCG39079 Grb2 ortho G G G G G G G G Grb2 Hadhb ortho G G G G G G G G Grb2 Snx17 ortho G G G G G G G G Ywhab Grb2 ortho G G G G G G G G Grb2 Inppl1 ortho G G G G G G G G Grb2 Tspan2 ortho G G G G G G G G Rps14 Grb2 ortho Ptpn1 Grb2 ortho G G Usp34 Grb2 ortho G G G G G G G G Grb2 Rab8b ortho G G G G G G Grb2 Psen1 ortho G G G G G G G G Protein Krt82, Type II keratin Kb22 Grb2 ortho Rps11 Grb2 ortho G G G G G G G G Grb2 Sh2d4a ortho G G G G G Protein Pdia2 Grb2 ortho Grb2 Nrif1 ortho G G G G G G G G Grb2 Hnrpr ortho G G G G G G G G Grb2 Rps6ka1 ortho G G G G Grb2 Cntfr ortho G G G G G G G Ruvbl1 Grb2 ortho G G G G G G Grb2 Foxj1 ortho G Grb2 Lax1 ortho Grb2 Tsg101 ortho G G G G G G G G Grb2 Fyn ortho G G G G G Mical1 Grb2 ortho Grb2 Trim39 ortho Krt85 Grb2 ortho Bad Grb2 ortho G G G G G G G G Grb2 Cct3 ortho G G G G G G G G Flna_predicted Grb2 ortho G G G G G G G Grb2 Ddx39b ortho G G G G G G G G Protein Clnk Grb2 ortho Grb2 Lmo7 ortho G G G G G G G G Drd3 Grb2 ortho G Csk Grb2 ortho G G G G G G G G Dlg4 Grb2 ortho G G G G G G Fh Grb2 ortho G G G G G G G G Grb2 Arhgap20 ortho Elavl4 Grb2 ortho G G G G G G G G Rps20 Grb2 ortho Rpl31 Grb2 ortho Copb1 Grb2 ortho G G G G G G G G Grb2 Cd72 molecule, Protein Cd72 ortho NEWGENE_1304700 Grb2 ortho G G G G G G G G Grb2 Sh2b2 ortho G Grb2 Aes ortho G G G G G G G G Protein Zmat1, RCG38044, isoform CRA_b Grb2 ortho Grb2 Sptbn1 ortho G G G G G G G G Grb2 Protein Tmx1, Thioredoxin domain containing 1 ortho G G G G G G G G Grb2 Casc3 ortho Protein Mylk Grb2 ortho G G G G G G G G Grb2 Krt73 ortho Grb2 ABI family, member 3, ABI gene family, member 3, isoform CRA_b, Protein Abi3 ortho Aebp1 Grb2 ortho G G G G Grb2 Slc24a1 ortho S100a8 Grb2 ortho G Protein Arhgap32 Grb2 ortho G G G G G G Nckap1 Grb2 ortho G G G G G G G G Grb2 Jak2 ortho G Grb2 Blnk ortho Ephb6 Grb2 ortho Vasp Grb2 ortho G G G G G G G G Grb2 Cnksr1 ortho Atp5b Grb2 ortho G G G G G G G G Ikbke_predicted Grb2 ortho Spry3 Grb2 ortho Grb2 Igf2bp1 ortho Egf Grb2 ortho Cat Grb2 ortho G G G G G G G G Grb2 Actinin alpha 3, isoform CRA_a, Protein Actn3, Skeletal muscle-specific alpha-actinin 3 ortho G Grb2 Ilf3 ortho G G G G G G G G Grb2 Nap1l5 ortho G G G G G Grb2 Khsrp ortho G G G G G G G G Tnfrsf1a Grb2 ortho G G G G G G G G Protein Ddx6, RCG58047 Grb2 ortho G G G G G G G Grb2 Hcn2 ortho G G G G G G G G Protein Sos1, Son of sevenless homolog 1 (Drosophila) Grb2 ortho G G G G G G G G Grb2 Rims2 ortho Grb2 Cfh ortho G G G G G G G Grb2 Fcgr2 ortho G G G G G Faslg Grb2 ortho G G G G Dnm2 Grb2 ortho G G Grb2 Pabpc1 ortho G G G G G G G G Grb2 Crbn ortho Tub Grb2 ortho Grb2 Golim4 ortho Grb2 E74-like factor 2, E74-like factor 2, isoform CRA_a, Protein Elf2 ortho G G G G G G G G Ptpre Grb2 ortho G G Grb2 HLA-B associated transcript 8, rat orthologue, Protein Ehmt2 ortho G G G G G G G G Pold1 Grb2 ortho G Cd300lb Grb2 ortho Grb2 Cttn ortho G G G G G G G G Engulfment and cell motility 2, ced-12 homolog (C. elegans), isoform CRA_b, Protein Elmo2 Grb2 ortho G G G G G G G Signal recognition particle 9 kDa protein, SRP9 Grb2 ortho G G G G G G G G Grb2 F2rl2 ortho G Grb2 Hnrnpd ortho G G G G G G G G Integrin, alpha 6, isoform CRA_b, Protein Itga6 Grb2 ortho G G G G G G Grb2 Bre ortho G G G G G G G G Grb2 Cyp4f3 ortho Protein Dock5 Grb2 ortho Safb Grb2 ortho G G G G G G Grb2 Tuba4a ortho G G G G G G G G Grb2 Ptpn6 ortho G G G G Cfl2_predicted Grb2 ortho G G G G G G G G Protein Snrpd2, RCG54604, Small nuclear ribonucleoprotein D2 Grb2 ortho G G G G G G G G Grb2 Mog ortho G G G G Dab2 Grb2 ortho G G G G G G G G Protein Ubash3b Grb2 ortho Eef2 Grb2 ortho G G G G G G G G Grb2 Adam17 ortho G G G G G G G G Pdpk1 Grb2 ortho G Apcs Grb2 ortho G G G G G G G G Grb2 Luzp1 ortho G G G G Grb2 Pak2 ortho G G G G G G G G Grb2 Sh3kbp1 ortho G G G G G G G G Grb2 Rbbp7 ortho G G G G G G G G Grb2 Fgfr1 ortho G G G G G G G G Ap2a1_predicted Grb2 ortho Rpl36 Grb2 ortho Csn2 Grb2 ortho Ksr1_predicted Grb2 ortho Ppp1cb Grb2 ortho G G G G G G G G Nr5a1 Grb2 ortho Grb2 Psmd10 ortho G G G G G G G G Efs_predicted Grb2 ortho G G G G Grb2 Pdlim7 ortho G G G Grb2 Arpc1a ortho G G G G G G G G Protein Shb Grb2 ortho G G G G G G G G Paics Grb2 ortho RGD1308106_predicted Grb2 ortho Grb2 Neu3 ortho Syn1 Grb2 ortho G G G G G G G G Protein Arap1 Grb2 ortho G G G G G G G G Grb2 Ywhah ortho G G G G G G G G Grb2 Hmgn3 ortho G G G G G G G G Grb10 Grb2 ortho G G G G G G G Protein LOC682102 Grb2 ortho Gpc1 Grb2 ortho G G G G G G G G Protein Golga3, RCG21481, isoform CRA_b Grb2 ortho Grb2 Pld2 ortho G G G Coro1b Grb2 ortho Mybpc2_predicted Grb2 ortho G G G Grb2 Dnaja3 ortho G G G G G G G G Grb2 Olig1 ortho G G G Panx2 Grb2 ortho Grb2 Amy1a ortho G Grb2 Pls3 ortho G G G G G G G G Grb2 Rpl10 ortho Grb2 Protein Ugp2, UDP-glucose pyrophosphorylase 2, UDP-glucose pyrophosphorylase 2, isoform CRA_b ortho G G G G G G G G Grb2 Bcl2-associated athanogene 3, Protein Bag3, RCG40209, isoform CRA_b ortho G G G G G G G G Gapdh Grb2 ortho G G G G G G G G Rb1 Grb2 ortho G G G G G G Ap1b1 Grb2 ortho G G G G G G G G Protein Pnma2, RCG52129 Grb2 ortho Tcp1 Grb2 ortho G G G G G G G G Clta Grb2 ortho G G G G G G G G RGD1307782 Grb2 ortho Cd28 Grb2 ortho LOC100362620 Grb2 ortho G G Gstp1 Grb2 ortho G G G G G G G G Grb2 Sde2 ortho G G G G G G G G Grb2 Hnrpu ortho G G G G G G G G Grb2 Protein Specc1, Sperm antigen with calponin homology and coiled-coil domains 1 ortho Magi2 Grb2 ortho Snx8_predicted Grb2 ortho Zbtb7b_predicted Grb2 ortho Grb2 Protein Tmod3, RCG25684, isoform CRA_a, Tropomodulin 3 ortho G G G G G G G G Socs4_predicted Grb2 ortho Grb2 Skap1 ortho Hipk3 Grb2 ortho Pak1 Grb2 ortho G G G G G G G G Adrb1 Grb2 ortho Grb2 Hexb ortho G G G G G G G G Protein Trim41 Grb2 ortho G G G G G G G G Hp Grb2 ortho G G G G G G Plec Grb2 ortho G G G G G G G G Dusp15_predicted Grb2 ortho Cd44 Grb2 ortho G G G G Psmd13 Grb2 ortho G G G G G G G G LOC361120 Grb2 ortho Protein Ap4s1 Grb2 ortho G G G G G G G G Map2 Grb2 ortho G G G G G G Hspa5 Grb2 ortho G G G G G G G G Protein Cd19 Grb2 ortho Protein Lmx1a Grb2 ortho MOB1, Mps One Binder kinase activator-like 2A (Yeast), MOB1, Mps One Binder kinase activator-like 2B (Yeast) (Predicted), isoform CRA_a, Protein Mob3a Grb2 ortho G G G G G G G Pias3 Grb2 ortho G G G G G G G G Kinesin-like protein Grb2 ortho G S100a6 Grb2 ortho G G G G G G G G Grin1 Grb2 ortho G G G G Grb2 Atad3 ortho G G G G G G G G Ppara Grb2 ortho Mertk Grb2 ortho G G G G Grb2 Cldn3 ortho G G G Grb2 Clasp2 ortho G G G G G G G Grb2 Tceal8 ortho G G G G G G G G Grb2 Krt5 ortho Protein Sh3bp1 Grb2 ortho G Aunip Grb2 ortho RGD1311045_predicted Grb2 ortho Grb2 Psmc2 ortho G G G G G G G G Ncl Grb2 ortho G G G G G G G G Protein Sh3bp2 Grb2 ortho Mapk9 Grb2 ortho G G Pik3c2b_predicted Grb2 ortho Pogz_predicted Grb2 ortho G G G G G G G Hspa9 Grb2 ortho Protein Radil, RCG42648, isoform CRA_a Grb2 ortho G G G Grb2 Ccl28 ortho G G G G G Protein Myh14 Grb2 ortho Extl1_predicted Grb2 ortho G Grb2 Fam110a ortho LOC684111 Grb2 ortho LOC100910240 Grb2 ortho G G G G G G Grb2 Rxra ortho Protein Dag1 Grb2 ortho G G G G G G G G Pde4d Grb2 ortho G G G G G G Grb2 Flt4 ortho Grb2 Khdrbs2 ortho Grb2 2,3-bisphosphoglycerate mutase, Protein Bpgm ortho G G G G G G G Grb2 Rbm4b ortho G G G G G G G G Dapk3 Grb2 ortho G G G G G G G G Sparcl1 Grb2 ortho G G G G G G G G Grb2 Apc ortho Ackr3 Grb2 ortho G G G G G G Snag1_predicted Grb2 ortho G G G G G G G G Grb2 Tubb4b ortho G G G G G G G G Mllt4 Grb2 ortho G G G G G G G G Ppie Grb2 ortho G G G G G G G G Grb2 Krt19 ortho G Histone H2B Grb2 ortho Grb2 Synpo ortho G G Grb2 Arhgap9_predicted ortho Frs2_predicted Grb2 ortho Grb2 Eif4a3 ortho G G G G G G G G Ret Grb2 ortho G G G Polyhomeotic-like 2 (Drosophila), Protein Phc2 Grb2 ortho G G G G G G G G Eps8 Grb2 ortho Grb2 Mprip ortho G G G G G G G G Grb2 Krt32 ortho Grb2 Krt8 ortho G G G G G G Grb2 Tlr9 ortho Dars Grb2 ortho G G G G G G G G Grb2 Slc25a5 ortho Grb2 Myl6 ortho Grb2 Capzb ortho G G G G G G G G Grb2 Dynll1 ortho Grb2 Hsph1 ortho G G G G G G G G Csrp1 Grb2 ortho G G G G G G G G Grb2 Arpc5 ortho G G G G G G G G Grb2 Eef1d ortho G G G G G G G G Grb2 Wdr1 ortho G G G G G G G G Esd Grb2 ortho G G G G G G G G Grb2 Rpl14 ortho G G G G G G G G App Grb2 ortho G G G G G G G G Cpne2 Grb2 ortho G G G G Grb2 LOC317380 ortho Grb2 Inpp5d ortho G G G G G G G G Grb2 RelA ortho G G G G G G G G Grb2 Ambp ortho G Igf1r Grb2 ortho G G G G G G G G Protein Pkp4 Grb2 ortho G G G G G G Grb2 Uba1 ortho G G G G G G G G Protein Nadk, RCG30800 Grb2 ortho G G G G G G G G Trim14 Grb2 ortho Grb2 Gab2 ortho Grb2 Mapk12 ortho G G G G G G G G Nup98 Grb2 ortho G G G G G G G G Grb2 Atp6v1e1 ortho G G G G G G G G Slc25a3 Grb2 ortho G G G G G G G G Prmt5_predicted Grb2 ortho G G G G G G G G Grb2 Dnajb11 ortho G G G G G G G G Grb2 Cyth2 ortho G G G G G G G G Grb2 Pdcd6ip ortho G G G G G G G G Ptk2 Grb2 ortho G G G G G G G G Grb2 Prkab1 ortho G G G G G G G G Nkx2-1 Grb2 ortho G G G G Grb2 Gsn ortho G G G G G G G G Grb2 Protein Tnfrsf14, Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator) ortho G G Grb2 Ptprs ortho G G G G G G G G Ash1l_predicted Grb2 ortho G G G G G G G G Grb2 Rai14 ortho G G G Flnc Grb2 ortho G G G G Prnp Grb2 ortho G G G G G G G G Grb2 COP9 (Constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana), COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), Protein Cops5 ortho G G G G G G G G Grb2 Krt15 ortho G G Ms4a2 Grb2 ortho G Ppp1r9b Grb2 ortho G G G G G G G G Alox5 Grb2 ortho G Errfi1 Grb2 ortho G G G G G G G Grb2 Myo1b ortho G G G G Grb2 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14, Protein Psmd14, Psmd14 protein, RCG26455, isoform CRA_b ortho Cckbr Grb2 ortho G Hnrnpa1 Grb2 ortho G G G G G G G Grb2 Inter alpha-trypsin inhibitor, heavy chain 4, Inter alpha-trypsin inhibitor, heavy chain 4, isoform CRA_a, Protein Itih4 ortho G G G G G Rpl18a Grb2 ortho G G G G G G G G Rpl13 Grb2 ortho Protein Acap1 Grb2 ortho G Protein RGD1307830 Grb2 ortho Ppm1b Grb2 ortho G G G G G G G G Ocrl Grb2 ortho Chrnd Grb2 ortho Grb2 Ptbp1 ortho G G G G G G G G Sh2d1a Grb2 ortho Phgdh Grb2 ortho G G G G G G G Rab11a Grb2 ortho G G G G G G G G Grb2 Protein Rdh11, Retinol dehydrogenase 11 (All-trans/9-cis/11-cis) ortho G G G G G G G G Protein Pygo1 Grb2 ortho Luc7l2_predicted Grb2 ortho G G G G G G G G S100a9 Grb2 ortho G Protein Ckap5 Grb2 ortho G G G G G G G G Grb2 Mlxipl ortho G G G Grb2 Ets variant 6, Protein Etv6 ortho Grb2 Pik3cb ortho Shkbp1 Grb2 ortho G G G G G Ppp2r2a Grb2 ortho G G G G G G G G Rin3_predicted Grb2 ortho G G G G Grb2 Crk ortho G G G G G G G G Slc1a2 Grb2 ortho Dctn1 Grb2 ortho G G G G G G G G Pdia4 Grb2 ortho G G G G G G G G Cblc Grb2 ortho Grb2 Ap2m1 ortho G G G G G G G G Grb2 Ube2i ortho G G G G G G G G Gpr45_predicted Grb2 ortho Rars Grb2 ortho G G G G G G G G Ly6d_predicted Grb2 ortho LOC680177 protein, Protein Prr22 Grb2 ortho Protein Vav3 Grb2 ortho Rpl23 Grb2 ortho G G G G G G G G Grb2 Socs1 ortho Grb2 Slco2a1 ortho G G DNA-directed RNA polymerase Grb2 ortho G G G G G G G G Map4k1_predicted Grb2 ortho G Sptan1 Grb2 ortho G G G G G G G G Gpr2_predicted Grb2 ortho Grb2 munc-18c ortho G G G G G G G G Grb2 Tubb3 ortho G G G G G Grb2 Itch ortho Protein Peak1, Similar to RIKEN cDNA C230081A13 (Predicted) Grb2 ortho Grb2 Actg2 ortho Irf5_predicted Grb2 ortho Tp53 Grb2 ortho G G G G G G G G Pbxip1 Grb2 ortho Ywhae Grb2 ortho G G G G G G G G Grb2 Epn2 ortho G G G G G G G G Grb2 Protein Smarcd3, RCG24403, isoform CRA_a, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 ortho G G G G Grb2 Pxn ortho G G G G G G G G Qdpr Grb2 ortho G G G G G G G G Grb2 Protein Spry2, Sprouty homolog 2 (Drosophila) ortho G G G G Protein Mycbp, RCG31143 Grb2 ortho Grb2 Slc23a1 ortho G G G G Grb2 Shroom2 ortho G G G G G G G G Grb2 Wasf1 ortho Trim27 Grb2 ortho G G G G G G G G Grb2 LOC683746 ortho Syp Grb2 ortho G G G G G G G G Grb2 Hematopoietic cell specific Lyn substrate 1, Protein Hcls1, RCG52681 ortho Grb2 Nf2 ortho G G G G G G G G Protein Vav2 Grb2 ortho G G G G Ghr Grb2 ortho G G G Tyrosine-protein phosphatase non-receptor type Grb2 ortho G G G G Grb2 Hnrnph2 ortho Grb2 Kcnn1 ortho Rps3 Grb2 ortho G G G G G G G G Grb2 Bcl2a1 ortho G G RGD1306656_predicted Grb2 ortho Grb2 Lzts2 ortho G G G G G G G G Grb2 Drg1 ortho Vim Grb2 ortho G G G G G G G G Grb2 Thrap3 ortho G G G G G G G G Grb2 Zkscan3 ortho Rps5 Grb2 ortho G G G G G G G G Grb2 Hspa8 ortho Grb2 Kirrel ortho Fabp1 Grb2 ortho G G G G Matr3 Grb2 ortho G G G G G G G G Cast Grb2 ortho G G G G G G G G Tf Grb2 ortho Grb2 Myo1c ortho G G G G G G G G Grb2 Ly6g6f ortho Grb2 Myo1a ortho Nek8 Grb2 ortho Grb2 Frs3 ortho G G G Rpl18 Grb2 ortho G G G G G G G G Rps28 Grb2 ortho Agt Grb2 ortho G G G G G G Fabp5 Grb2 ortho G G G G G G G G Grb2 Tppp3 ortho G G G G RGD1559449_predicted Grb2 ortho G G G G G G G G Rpl21 Grb2 ortho Grb2 Htra1 ortho G G G G G G G G Grb2 Ywhaq ortho G G G G G G G G Rit1_predicted Grb2 ortho G G G G G Grb2 Fscn1 ortho RGD1311593_predicted Grb2 ortho G G G G G G G G Grb2 Grap2 ortho Gcdh_predicted Grb2 ortho G G G G G G G G Grb2 Hdgfrp3 ortho G G G G RGD1563421_predicted Grb2 ortho Grb2 Ptk2b ortho G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P06748 P62994 - 8633037 - X 2 P30530 P62994 - 9178760 - X 2 P30530 P62994 - 9178760 - X 2 P30530 P62994 - 9178760 - X 2 P62994 P00813 - 9299436 - X 2 P62994 P00813 - 9299436 - X 2 P62994 Q9Z1I0 - 9704577 - X 2 P62994 Q9Z1I0 - 9710602 - X 2 P62994 - 9764818 - X 2 P62994 P00813 - 9299436 - X 2 P62994 - 9764818 - X 2 P62994 - 9764818 - X 2 P62994 - 9516488 - X 2 P62994 - 9764818 - X 2 Q63429 P62994 affinity chromatography technology 22871113 physical association X 2 P62994 Q05193 affinity chromatography technology 9259551 physical association X 2 P62994 G3V8S2 affinity chromatography technology 9722539 physical association X 2 P62994 G3V8S2 affinity chromatography technology 9918770 physical association X 2 P62994 Q9QX70 affinity chromatography technology 12218049 physical association X 2 P62994 G3V8S2 affinity chromatography technology 12167719 physical association X 2 P35570 P62994 affinity chromatography technology 12960006 physical association X 2 P35570 P62994 affinity chromatography technology 12960006 physical association X 2 P62994 F1MAL5 affinity chromatography technology 12960006 physical association X 2 P62994 F1MAL5 affinity chromatography technology 12960006 physical association X 2 P62994 affinity chromatography technology 9918770 physical association X 2 P62994 E9PT20 affinity chromatography technology 8663064 physical association X 2 P62994 affinity chromatography technology 7953556 physical association X 2 P62994 P29353-5 affinity chromatography technology 7953556 physical association X 2 P62994 coimmunoprecipitation 72012467 association C 3 P62994 Q9QX70 anti bait coimmunoprecipitation 7798267 association X 2 P62994 Q9Z1I0 anti bait coimmunoprecipitation 7798267 association X 2 P62994 coimmunoprecipitation 10660596 association C 3 P62994 pull down 16518874 association C 51 Q6IN36 P62994 anti bait coimmunoprecipitation 16990791 physical association X 2 Q5M824 P62994 coimmunoprecipitation 12446583 physical association X 2 P62994 Q14118 enzyme linked immunosorbent assay 10903901 direct interaction X 2 P62994 Q07889 coimmunoprecipitation 11726515 physical association X 2 P62994 P35235 coimmunoprecipitation 12531430 association X 2 P62994 P35235 coimmunoprecipitation 12531430 association X 2 P62994 P18545 pull down 16357825 direct interaction X 2 P62994 P18545 two hybrid 16357825 physical association X 2 P62994 P21575 pull down 17437541 physical association X 2 P62994 P21575 pull down 17437541 physical association X 2 P62994 P21575 competition binding 17437541 physical association X 2 P62994 P11274 coimmunoprecipitation 7529874 association X 2 P62994 Q13094 pull down 7706237 direct interaction X 2 P62994 Q9QX70 coimmunoprecipitation 7798267 physical association X 2 P62994 P22681 coimmunoprecipitation 8621719 physical association X 2 P62994 P22681 pull down 8621719 direct interaction X 2 P62994 P22681 pull down 8662998 direct interaction X 2 P62994 P22681 coimmunoprecipitation 8662998 physical association X 2 P62994 P10686 coimmunoprecipitation 9281317 association X 2 P62994 P10686 coimmunoprecipitation 9281317 association X 2 P62994 Q13094 pull down 9716598 direct interaction X 2 P62994 P22681 coimmunoprecipitation 9716598 physical association X 2 P62994 Q13094 coimmunoprecipitation 9716598 physical association X 2 P62994 P11274 coimmunoprecipitation 9826659 physical association X 2 Q9NZQ3 P62994 pull down 11509578 direct interaction X 2 Q9NZQ3 P62994 coimmunoprecipitation 11509578 physical association X 2 O43426 P62994 phage display 11292345 direct interaction X 2 O43426 P62994 pull down 11292345 direct interaction X 2 P35570 P62994 coimmunoprecipitation 12446583 physical association X 2 Q16190 P62994 coimmunoprecipitation 11726515 physical association X 2 Q16190 P62994 experimental interaction detection 11726515 association X 2 P41499 P62994 anti bait coimmunoprecipitation 21946312 physical association X 2 P62994 P35739 pull down 10748052 association X 2 P62994 P35739 coimmunoprecipitation 10748052 association X 2 P62994 P35739 pull down 10748052 association X 2 P62994 P35739 two hybrid 10748052 physical association X 2 P62994 P35739 two hybrid 10748052 physical association X 2 P62994 P35739 coimmunoprecipitation 10748052 association X 2 P62994 A8K3M3 pull down 12023880 physical association X 2 P62994 P29353 coimmunoprecipitation 7798267 physical association X 2 P62994 P29353 pull down 8084588 association X 2 P62994 P27986 coimmunoprecipitation 8621719 physical association X 2 P62994 P29353 coimmunoprecipitation 8621719 physical association X 2 P62994 P29353 coimmunoprecipitation 8662998 physical association X 2 P62994 P27986 coimmunoprecipitation 8662998 physical association X 2 P62994 P00533 coimmunoprecipitation 8662998 physical association X 2 P62994 A8K3M3 pull down 8940134 physical association X 2 P62994 A8K3M3 pull down 8940134 physical association X 2 P62994 P29353 coimmunoprecipitation 9083103 association X 2 P08487 P62994 pull down 9281317 association X 2 P08487 P62994 pull down 9281317 association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Irs1 Grb2 MI:0434(phosphatase assay)|MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0434(phosphatase assay) 12446583,12960006 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(biogrid)|(intact) MINT_68893|BIOGRID_335867|BIOGRID_335869|UniProt_181612 bait|prey|bait|bait prey|bait|prey|prey Grb2 Irs2 MI:0415(enzymatic study)|MI:0415(enzymatic study) 12960006 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_335870|BIOGRID_335868 prey|bait bait|prey Ntrk1 Grb2 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 10748052 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact) MINT_79769|MINT_79768|MINT_79767|UniProt_181460|UniProt_181456|UniProt_181455|MINT_79444|UniProt_181459|UniProt_181458|MINT_79446|MINT_79445|UniProt_181457 unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role Grb2 Cbl MI:0004(affinity chromatography technology) 9918770 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_335963 prey bait Grb2 Shc1 MI:0004(affinity chromatography technology)|MI:0434(phosphatase assay)|MI:0004(affinity chromatography technology)|MI:0434(phosphatase assay)|MI:0415(enzymatic study) 12167719,12446583,9722539,9918770 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(biogrid)|(intact)|(biogrid) BIOGRID_333840|MINT_68740|BIOGRID_335962|UniProt_181611|BIOGRID_335223 prey|prey|prey|prey|prey bait|bait|bait|bait|bait Plcg1 Grb2 MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation) 9281317 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (intact)|MI:0471(mint)|MI:0471(mint)|(intact) UniProt_186886|MINT_79734|MINT_79729|UniProt_186887 unspecified role|unspecified role|unspecified role|unspecified role unspecified role|unspecified role|unspecified role|unspecified role Grb2 Egfr MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation) 7798267 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|(intact) UniProt_186779|MINT_86175|UniProt_133700 prey|prey|prey bait|bait|bait Ptpn11 Grb2 MI:0006(anti bait coimmunoprecipitation) 21946312 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (intact) UniProt_185181 prey bait Grb2 Wipf1 MI:0096(pull down)|MI:0096(pull down) 16990791 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_84070|UniProt_184287 null|null bait|bait Grb2 Ubc MI:0004(affinity chromatography technology) 22871113 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_336428 prey bait Grb2 Grb2 MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation) 9281317 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) MI:0471(mint)|MI:0471(mint)|(intact)|(intact) MINT_79735|MINT_79730|UniProt_186889|UniProt_186888 unspecified role|unspecified role|unspecified role|unspecified role unspecified role|unspecified role|unspecified role|unspecified role Dnm1 Grb2 MI:0405(competition binding)|MI:0405(competition binding)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0405(competition binding) 10,17437541 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|MI:0471(mint) MINT_71866|MINT_71865|UniProt_183606|UniProt_183608|UniProt_183605|MINT_71864 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality SYNJ2 GRB2 11498538 0047 LC ERBB2 GRB2 13679576 0019 LC PLCG1 GRB2 9281317 0019 LC DNM1 GRB2 17437541,17437541 0405,0096 LC IRS1 GRB2 12446583 0019 LC NTRK1 GRB2 10748052,10748052,10748052 0019,0096,0018 LC GRB2 SHC1 12446583 0019 LC GRB2 EGFR 7798267,7798267 0019,0006 LC CBL GRB2 9918770 0004 LC ABL1 GRB2 8663064 0004 LC IRS2 GRB2 12960006 0004 LC DNM1 GRB2 11877424,17437541,17437541 0004,0405,0096 LC IRS1 GRB2 12960006 0004 LC NTRK1 GRB2 10748052,10748052,10748052 0019,0096,0018 LC PTPN11 GRB2 21946312 0006 LC HNRNPK GRB2 16518874 0096 LC GRB2 SHC1 12167719,9722539,7798267,9918770 0004,0004,0006,0004 LC GRB2 WIPF1 16990791 0006 LC GRB2 FLT3 8183574 0004 LC GRB2 EGFR 12218049,7798267,7798267 0004,0019,0006 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P62994 P22681 GRB2 CBL 0.765 8621719,9716598,8662998 P62994 O43295 GRB2 SRGAP3 0.21 25819436 P62994 P61980 GRB2 HNRNPK 0.126 16518874 Q63429 P62994 UBC GRB2 0.126 22871113 P62994 P08487 GRB2 PLCG1 0.21 9281317 Q6IN36 P62994 WIPF1 GRB2 0.21 16990791 P62994 P10686 GRB2 PLCG1 0.21 9281317 P62994 P06213 GRB2 INSR 0.21 7953556 P62994 P11274 GRB2 BCR 0.376 9826659,7529874 P62994 P18545 GRB2 PDE6G 0.523 16357825 Q16190 P62994 BCR/ABL GRB2 0.376 11726515 P62994 O43426 GRB2 SYNJ1 0.523 11292345 P62994 P35739 GRB2 NTRK1 0.765 10748052 Q9NZQ3 P62994 NCKIPSD GRB2 0.454 11509578 Q13094 P62994 LCP2 GRB2 0.623 7706237,9716598 P62994 P29353 GRB2 SHC1 0.757 8662998,9083103,7798267,8084588,8621719,7953556 Q5M824 P62994 SHC1 GRB2 0.61 12167719,12446583,9722539,9918770 P62994 P27986 GRB2 PIK3R1 0.376 8621719,8662998 P62994 P41499 GRB2 PTPN11 0.21 21946312 Q14118 P62994 DAG1 GRB2 0.309 10903901 Q9QX70 P62994 EGFR GRB2 0.21 7798267 Q07889 P62994 SOS1 GRB2 0.21 11726515 P62994 P21575 GRB2 DNM1 0.376 17437541 P62994 P00533 GRB2 EGFR 0.21 8662998 P62994 P18031 GRB2 PTPN1 0.507 12023880,8940134 Q05193 P62994 DNM1 GRB2 0.21 9259551 P62994 P35570 GRB2 IRS1 0.507 12446583,12960006 P62994 P35235 GRB2 PTPN11 0.21 12531430