PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Traf6 Khdrbs1 16079148 biogrid exp Traf6 Nrif1 16252010 biogrid exp Traf6 Prkcg 16079148 biogrid exp Traf6 Ntrk1 16246731 biogrid exp, ortho Numbl Traf6 20079715 biogrid exp, ortho Traf6 Ikbkb 16079148 biogrid exp, ortho Traf6 Sqstm1 16252010 biogrid exp, ortho Traf6 Mob1a ortho Bag2 Traf6 ortho Traf6 Actn1 ortho Traf6 Ube2s ortho Traf6 Mavs ortho Traf6 Fyn ortho Traf6 Mat2a ortho Traf6 Gxylt1 ortho Traf6 Dync1h1 ortho Traf6 Ikbke_predicted ortho Traf6 Interferon-induced protein with tetratricopeptide repeats 3, Protein Ifit3 ortho Traf6 Ptpn11 ortho Traf6 Cdc37 ortho Traf6 Tagln2 ortho Traf6 Irf4_predicted ortho Traf6 Cacybp ortho Traf6 Lat ortho Traf6 Strap ortho Traf6 Eif3s12_predicted ortho Traf6 Protein Il17ra ortho Traf6 Tlr4 ortho Traf6 Protein Heatr3 ortho Traf6 Actn4 ortho Traf6 Map2k7 ortho Traf6 LOC100365869 ortho Traf6 Rpl36 ortho Traf6 Hdac1 ortho Traf6 Dhx9_predicted ortho Traf6 Bpnt1 ortho Traf6 Rps9 ortho Traf6 Otub2_predicted ortho Protein Spop, Speckle-type POZ protein, isoform CRA_a, Spop protein Traf6 ortho Traf6 Ube2d3 ortho Traf6 Rtn4 ortho Traf6 Protein G3bp1 ortho Traf6 Wdr5 ortho Traf6 Atp2a2 ortho Traf6 Vars ortho Traf6 Esr1 ortho Traf6 Canx ortho Traf6 Tfrc ortho Traf6 Khsrp ortho Traf6 Src ortho Traf6 Nudt5 ortho Traf6 RGD1565840_predicted ortho Traf6 Pa2g4 ortho Traf6 Il17re ortho Traf6 Protein Malt1 ortho Traf6 Cd81 ortho Traf6 Psmd2 ortho Traf6 Vps52 ortho Traf6 Ube2v2 ortho Traf6 Nrcam ortho Traf6 Tgfbr2 ortho Traf6 Sra1 ortho Eif3i Traf6 ortho Limd1 Traf6 ortho Spfh1_predicted Traf6 ortho Traf6 Cav1 ortho Traf6 Hprt1 ortho Traf6 Protein Ticam2, RCG46790 ortho Traf6 Usp15 ortho Traf6 Pno1 ortho Traf6 Psmc4 ortho Traf6 Ssb ortho Traf6 Mapk8 ortho Traf6 Trim37 ortho Traf6 Hadha ortho Traf6 Protein Slirp, RCG20695, isoform CRA_b ortho Traf6 Ube2n ortho Traf6 Protein Sar1a, SAR1 gene homolog A (S. cerevisiae), isoform CRA_b, SAR1 homolog A (S. cerevisiae) ortho Traf6 Nat13 ortho Traf6 Protein RGD1565297, RCG36598 ortho Traf6 Snca ortho Traf6 Rbck1 ortho Traf6 Hspb2 ortho Traf6 Hsp90ab1 ortho Traf6 Atic ortho Traf6 Psmb3 ortho Traf6 Mif ortho Traf6 RGD1564719_predicted ortho Traf6 Tbca ortho Traf6 Htt ortho Il17rb_predicted Traf6 ortho Traf6 Ipo7_predicted ortho Traf6 Eef1a2 ortho Eda2r_predicted Traf6 ortho Traf6 Rab10 ortho Traf6 Ppp4c ortho Traf6 Cyb5a ortho Traf6 Mtco2 ortho Traf6 Eif2ak2 ortho Traf6 Atp5j2 ortho Traf6 Ubc ortho Traf6 Ak2 ortho Traf6 Protein Rangap1, RCG59652, isoform CRA_b ortho Traf6 Ptpn6 ortho Traf6 Ulk1_mapped ortho Traf6 Tax1bp1 ortho Traf6 Csf2rb ortho Traf6 Pdia6 ortho Traf6 Gdi2 ortho Traf6 Chromosome 6 open reading frame 4, isoform CRA_a, Protein Traf3ip2, Traf3 interacting protein 2 ortho Traf6 Becn1 ortho Traf6 Dcbld2 ortho Traf6 Polyribonucleotide nucleotidyltransferase 1, Protein Pnpt1 ortho Traf6 Psmb5 ortho RGD1305031 Traf6 ortho LOC682908 protein, Protein Rcc1, RCG31301, isoform CRA_a Traf6 ortho Traf6 Eif4e ortho Traf6 Nlrx1 ortho Traf6 Protein Atp6v1a, RCG52629 ortho Traf6 Nfatc2ip ortho Traf6 Cnp ortho Traf6 Dnaja1 ortho Traf6 Olr921 ortho Traf6 Nudt21 ortho Traf6 Myd88 ortho Traf6 Aldoa ortho Psmd13 Traf6 ortho Traf6 Baculoviral IAP repeat-containing 2, Protein Birc2 ortho Prkcsh_predicted Traf6 ortho Tollip Traf6 ortho Traf6 Dcxr ortho Traf6 Tram1 ortho Traf6 RGD1310121_predicted ortho Traf6 Hif1a ortho Traf6 Rpl35 ortho Traf6 Kras ortho Traf6 Protein Rnf126, Ring finger protein 126 ortho Traf6 Atm_mapped ortho Traf6 Ikbkg ortho Traf6 Lgmn ortho Traf6 Traf3_predicted ortho Traf6 RGD1564010_predicted ortho Traf6 Atxn3 ortho Traf6 Sae1 ortho Traf6 Xiap ortho Traf6 Antisecretory factor, Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 4, isoform CRA_a, Protein Psmd4 ortho Traf6 Gnai3 ortho Traf6 Lgals7 ortho Traf6 App ortho Traf6 Protein Rnf41, Ring finger protein 41 ortho Protein Trmt112, Similar to RIKEN cDNA 0610038D11 (Predicted), isoform CRA_b, Uncharacterized protein Traf6 ortho Traf6 Psma1 ortho Traf6 Nedd8 ortho Traf6 Protein Psmd8 ortho Traf6 Nasp ortho Traf6 Paics ortho Traf6 Parp1 ortho Traf6 Stambp ortho Traf6 Pnp ortho Traf6 Tgfbr1 ortho Traf6 Irf1 ortho Traf6 Ngfr ortho Traf6 Pcna ortho Traf6 Protein Il17rd ortho Traf6 Protein Tubb6, Tubulin, beta 6 ortho Traf6 Protein Rptor ortho Traf6 Pxn ortho Traf6 Npm1 ortho Traf6 Tufm ortho Traf6 Protein LOC100360606, RCG48022, isoform CRA_a ortho Traf6 Hras ortho Traf6 Protein Msr1 ortho Traf6 Ech1 ortho Traf6 LOC687813 ortho Traf6 Mtpn ortho Traf6 Capzb ortho Traf6 Mapre1 ortho Traf6 Tnfsf11 ortho Traf6 Foxg1 ortho Traf6 Tank ortho Uba2 Traf6 ortho Traf6 Protein Ruvbl2, RuvB-like 2 (E. coli) ortho Traf6 ICSBP ortho Traf6 Hspe1 ortho Traf6 Rap1a ortho Traf6 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 6, Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 6, isoform CRA_a, Protein Psmd6 ortho Traf6 Phb2 ortho Traf6 Glud1 ortho Traf6 CD40 molecule, TNF receptor superfamily member 5, Protein Cd40, Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a ortho Traf6 Copg1 ortho Traf6 Ecsit ortho Traf6 Fhl1 ortho Traf6 Psen2 ortho Traf6 Fastkd2 ortho Traf6 Psmc5 ortho Traf6 Map3k7 ortho Traf6 Eif1a ortho Traf6 Rnf114 ortho Traf6 Hspa8 ortho Protein Traf7, Traf7 protein Traf6 ortho Traf6 Psmd1 ortho Traf6 Runx1 ortho Traf6 Uba52 ortho Traf6 Sept9 ortho Traf6 Traf3ip1 ortho Traf6 Psmc3 ortho Traf6 Hspa1l ortho Traf6 Bri3 binding protein, Protein Bri3bp, Similar to BRI3-binding protein ortho Traf6 Gmfb ortho Traf6 Trim17 ortho Traf6 Stat3 ortho Traf6 Fabp5 ortho Traf6 Psen1 ortho Traf6 Sumo1 ortho Traf6 Nap1l1 ortho Traf6 Rcn2 ortho Traf6 Psma3 ortho Esd Traf6 ortho Traf6 Clip4 ortho Traf6 Tars ortho Traf6 Ripk1_predicted ortho Traf6 Rab11a ortho Traf6 Tlr3 ortho Cul1_predicted Traf6 ortho Traf6 Fscn1 ortho Traf6 Plekho1 ortho Traf6 Tnfrsf1b ortho Traf6 Ap2a1_predicted ortho Traf6 Traf2_predicted ortho Traf6 Tmem109 ortho Traf6 Ube2d2b ortho Traf6 Usp7 ortho Traf6 Il1rap ortho Tubb4 Traf6 ortho Traf6 Irak2 ortho Traf6 Pebp1 ortho Traf6 Flna_predicted ortho Traf6 Kpnb1 ortho Traf6 Irf5_predicted ortho Traf6 Pfkp ortho Traf6 Tnfrsf17_predicted ortho Traf6 Uchl1 ortho Traf6 Cblb ortho Traf6 Sec11a ortho Traf6 Traf6 ortho Traf6 Il1r1 ortho Traf6 Ube2d2 ortho Traf6 Map2k1 ortho Traf6 Arrb2 ortho Traf6 Nr0b2 ortho Traf6 Shc1 ortho Capza1 Traf6 ortho Traf6 Atp6v1e1 ortho Traf6 Tlr9 ortho Traf6 Sarm1_predicted ortho Traf6 Actg1 ortho Traf6 Set ortho Traf4_predicted Traf6 ortho Traf6 Hyou1 ortho Traf6 Tab2 ortho Traf6 Protein Ripk2, RCG54865 ortho Traf6 Vdac2 ortho Traf6 Ppm1g ortho Traf6 Rragc_predicted ortho Traf6 Sdcbp ortho Traf6 Hsp90aa1 ortho Traf6 Psma4 ortho Traf6 Calr ortho Traf6 Dnd1 ortho Traf6 Yes1 ortho Peli3_predicted Traf6 ortho Traf6 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14, Protein Psmd14, Psmd14 protein, RCG26455, isoform CRA_b ortho Traf6 Psmb2 ortho Traf6 Il1b ortho Traf6 Psmd7_predicted ortho Traf6 Rps11 ortho Traf6 Mtor ortho Traf6 Lrrc59 ortho Traf6 Cyld ortho Traf6 E3 ubiquitin-protein ligase ortho Traf6 Protein Zmynd11 ortho Traf6 Itgb1 ortho Traf6 Rab7a ortho Traf6 Psmc2 ortho Traf6 Eif2s1 ortho LOC686323 protein, Protein Trip6, RCG21591, isoform CRA_a Traf6 ortho Traf6 Tifa ortho Traf6 Psma6 ortho Traf6 Syk ortho Traf6 Ptges3 ortho Traf6 Prep ortho Traf6 Protein Npepps ortho Traf6 Prmt1 ortho Protein Rhoc, Ras homolog gene family, member C Traf6 ortho Traf6 Bcl10 ortho Traf6 Kcnq1 ortho Traf6 Jak2 ortho Traf6 Akr1b1 ortho Traf6 Pink1_predicted ortho Traf6 Trafd1 ortho Traf6 Usp2 ortho Traf6 Sdccag8 ortho Traf6 Tnfrsf19 ortho Traf6 Tomm20 ortho Traf6 Tmbim6 ortho Traf6 Eef1d ortho Traf6 Ppp4r1 ortho Traf6 Protein Mrto4, RCG31507, isoform CRA_a ortho March5_predicted Traf6 ortho Traf6 Map3k8 ortho Traf6 Tomm70a ortho Traf6 RGD1307595_predicted ortho Traf6 Hspa9 ortho Traf6 Ube2m_predicted ortho Traf6 Akt1 ortho Traf6 Trim25 ortho Traf6 Protein Tjp2, Tight junction protein 2 ortho Traf6 Ddb1 ortho Traf6 Card15_predicted ortho Traf6 Rac1 ortho Traf6 Actr3 ortho Traf6 Ppp2cb ortho Traf6 Sphk1 ortho Traf6 Map4k4_predicted ortho Traf6 Protein Stub1, STIP1 homology and U-Box containing protein 1, isoform CRA_b ortho Traf6 Protein Fblim1 ortho Traf6 Map3k14_predicted ortho Traf6 Protein Otud7b, RCG51753 ortho Traf6 Csnk1g1 ortho Traf6 Gsto1 ortho Traf6 Psmb4 ortho Sept11 Traf6 ortho Traf6 Aprt ortho Usp4 Traf6 ortho Traf6 Eef2 ortho Traf6 LOC299827 ortho Traf6 Protein Ern1 ortho Traf6 Dupd1 ortho Ctps Traf6 ortho Traf6 Arrb1 ortho Traf6 Protein Ubox5, Similar to Rnf37-pending protein, U-box domain containing 5 ortho Traf6 Hspa4l ortho Traf6 Usp34 ortho Traf6 Protein Tarsl2, Threonyl-tRNA synthetase-like 2 ortho Traf6 Cs ortho Traf6 Interferon regulatory factor 7, Protein Irf7 ortho Traf6 Rsad2 ortho Traf6 Fancd2 ortho Traf6 Park7 ortho Traf6 Tubb2b ortho Traf6 Protein Cbl ortho Traf6 Rpl18a ortho Traf6 Apex1 ortho Traf6 Bub3 ortho Traf6 Stip1 ortho Traf6 Trim28 ortho Traf6 Tubb5 ortho Traf6 Usp39_predicted ortho Traf6 Pdia4 ortho Traf6 Protein Wdr24, RCG32838 ortho Traf6 Ube2d1 ortho Traf6 Nr2c2 ortho Protein Traip, RCG25586, isoform CRA_a, TRAF-interacting protein Traf6 ortho Traf6 Bag6 ortho Traf6 Ajuba ortho Traf6 Ccl20 ortho Traf6 Ddx21 ortho Traf6 Psma2 ortho Traf6 Protein Wdr34, WD repeat domain 34 ortho Traf6 Psmc1 ortho Traf6 Oat ortho Traf6 Protein Eif4g1 ortho Traf6 RGD1565884_predicted ortho Traf6 Fhl2 ortho Traf6 Ccdc67 ortho Traf6 Map2 ortho Traf6 Casp8 ortho Traf6 Nup62 ortho Traf6 Ube2i ortho Traf6 Pgrmc1 ortho Traf6 Ppib ortho Traf6 Etf1 ortho Traf6 Mast2_predicted ortho Traf6 Tdp2 ortho Traf6 Hspa5 ortho Traf6 Vcp ortho Traf6 Phpt1_predicted ortho Traf6 Yars ortho Traf6 Eef1a1 ortho Traf6 Iars_predicted ortho Traf6 Taldo1 ortho Traf6 Anxa2 ortho Traf6 Ezr ortho Traf6 Pdlim7 ortho Traf6 Mcl1 ortho PDZ domain-containing protein 2, Peptidylprolyl cis/trans isomerase, NIMA-interacting 1, Protein (Peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (Predicted), isoform CRA_a Traf6 ortho Traf6 Txn ortho Traf6 Eif2s3 ortho Traf6 Protein Ppp2r1a, Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform, isoform CRA_a, Protein phosphatase 2 (Formerly 2A), regulatory subunit A, alpha isoform ortho Traf6 Prkcz ortho Traf6 Actr2 ortho Traf6 Mlec ortho Traf6 Transcription factor BTF3 ortho Traf6 Ruvbl1 ortho Traf6 Rpl24 ortho Traf6 Il17a ortho Traf6 Interferon regulatory factor 3, Interferon regulatory factor 3, isoform CRA_c, Protein Irf3 ortho Traf6 Map3k11 ortho Traf6 Gtf2i ortho Traf6 Snap29 ortho Traf6 Hspa4 ortho Traf6 Ctage5 ortho Traf6 Poli_predicted ortho Traf6 RNCASP9 ortho Traf6 Camlg ortho Traf6 Ccne1 ortho Traf6 Protein Irak4 ortho Traf6 Protein Medag ortho Traf6 Tmed7 ortho Zfand5 Traf6 ortho Traf6 Tubb3 ortho RGD1564594 Traf6 ortho Traf6 Hrsp12 ortho Traf6 Thrap3 ortho Traf6 DNA helicase ortho Traf6 Vdac1 ortho Traf6 Mthfd1 ortho Traf6 Hspa2 ortho Traf6 Rexo2 ortho Traf6 Cd44 ortho Traf6 Protein Tab1, RCG59826 ortho Traf6 Map3k3_predicted ortho Traf6 Mapk7 ortho Traf6 Birc3 ortho Protein Rab5c, RCG32615, isoform CRA_a, Rab5c protein Traf6 ortho Traf6 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3, Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3, isoform CRA_b, Protein Psmd3 ortho Traf6 LOC683206 ortho Traf6 Ntrk2 ortho Traf6 Mitochondrial ribosomal protein L13, Mitochondrial ribosomal protein L13, isoform CRA_a, Protein Mrpl13 ortho Traf6 Igf2r ortho Traf6 RGD1559449_predicted ortho Traf6 Tmed10 ortho Traf6 Actb ortho Traf6 Etfa ortho Traf6 Ccdc59_predicted ortho Traf6 Rhpn2_predicted ortho Traf6 Chuk_predicted ortho Traf6 Pafah1b2 ortho Traf6 Protein Mars ortho Traf6 Prpsap1 ortho Traf6 Ganab_predicted ortho Traf6 Rbbp7 ortho Traf6 St13 ortho Irak3_predicted Traf6 ortho Traf6 Mkk6 ortho Plekhf2_predicted Traf6 ortho Traf6 Ahcy ortho Traf6 Usp1 ortho Traf6 Vps35_mapped ortho Traf6 Aimp2 ortho Traf6 Mapkbp1_predicted ortho Traf6 Sigirr ortho Traf6 Inpp5d ortho Traf6 Nup155 ortho Traf6 S100a11 ortho Traf6 Psmd11 ortho Traf6 Pabpc1 ortho Traf6 Slc16a1 ortho Traf6 Itch ortho Traf6 Eif3e ortho Traf6 Atp5o ortho Traf6 Lrpprc ortho Traf6 Cyb5b ortho Traf6 Ybx1 ortho Traf6 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12, Protein Psmd12 ortho Traf6 Socs3 ortho Traf6 Protein Cdc34, RCG29282, isoform CRA_b ortho Traf6 Il1rl1 ortho Traf6 Socs1 ortho Traf6 Gars ortho Traf6 Eral1 ortho Irak1_predicted Traf6 ortho Traf6 Msn ortho Traf6 Pkm ortho Traf6 Tsn ortho Traf6 Gnb2 ortho Traf6 Meox2 ortho Usp21 Traf6 ortho Traf6 Atp5b ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants B5DF45 P63319 affinity chromatography technology 16079148 physical association X 2 B5DF45 Q3MUI2 affinity chromatography technology 20079715 physical association X 2 B5DF45 Q4V8E9 affinity chromatography technology 16252010 physical association X 2 B5DF45 Q4V8E9 affinity chromatography technology 16252010 physical association X 2 B5DF45 P35739 affinity chromatography technology 16246731 physical association X 2 Q63429 B5DF45 affinity chromatography technology 16079148 physical association X 2 B5DF45 affinity chromatography technology 16079148 physical association X 2 B5DF45 O08623 affinity chromatography technology 16252010 physical association X 2 B5DF45 O08623 affinity chromatography technology 16252010 physical association X 2 Q91V33 B5DF45 affinity chromatography technology 16079148 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality TRAF6 SQSTM1 16252010 0004 LC TRAF6 TAGLN 26291555,26291555 0004,0096 LC TRAF6 NTRK1 16246731,25708205 0004,0004 LC TRAF6 PRKCG 16079148 0004 LC TRAF6 NUMBL 20079715 0004 LC TRAF6 NRIF1 16252010 0004 LC TRAF6 UBC 16079148 0004 LC TRAF6 KHDRBS1 16079148 0004 LC TRAF6 IKBKB 16079148 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P35739 B5DF45 NTRK1 TRAF6 0.376 16246731,25708205 B5DF45 A1L1I3 TRAF6 NUMBL 0.21 20079715 O08623 B5DF45 SQSTM1 TRAF6 0.376 16252010 P31232 B5DF45 TAGLN TRAF6 0.569 26291555 P63319 B5DF45 PRKCG TRAF6 0.21 16079148 Q4V8E9 B5DF45 NRIF1 TRAF6 0.376 16252010 Q91V33 B5DF45 KHDRBS1 TRAF6 0.21 16079148 Q9QY78 B5DF45 IKBKB TRAF6 0.21 16079148