PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Apaf1 RNCASP9 16979168 mint,intact exp, ortho G Huntingtin interacting protein 1, isoform CRA_a, Protein Hip1 Apaf1 ortho G Apaf1 Apaf1 ortho G Apaf1 Xiap ortho Aven_predicted Apaf1 ortho Apaf1 Top1 ortho G Casp3 Apaf1 ortho G Hsp90aa1 Apaf1 ortho Bcl2l10 Apaf1 ortho G Ywhae Apaf1 ortho G Ppp1ca Apaf1 ortho G Elavl4 Apaf1 ortho G Apaf1 Casp8 ortho G Serine hydroxymethyltransferase Apaf1 ortho G Fas Apaf1 ortho Bcl2l1 Apaf1 ortho G Hspa4 Apaf1 ortho G Fem1b Apaf1 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9JHK1 Q9EPV5 anti bait coimmunoprecipitation 16979168 physical association X 2 Q9EPV5 O00291 anti tag coimmunoprecipitation 16979168 physical association X 2 Q9EPV5 O00291 pull down 16979168 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Apaf1 Casp9 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 16979168 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|(intact) UniProt_183379|MINT_83863|UniProt_88246 prey|prey|prey bait|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality APAF1 CASP9 16979168 0006 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9JHK1 Q9EPV5 CASP9 APAF1 0.21 16979168 Q9EPV5 O00291 APAF1 HIP1 0.376 16979168