PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Lyn Ubc 22871113,14531861,11137137 biogrid exp, ortho Ms4a2 Lyn 19356729 biogrid exp, ortho G DNA helicase Lyn 23764002 intact exp, ortho G G G G Lyn Lyn 14604964 biogrid exp, ortho G G G G Hsp90aa1 Lyn 19356729 biogrid exp, ortho Protein Cbl Lyn 14531861,8627181 biogrid exp, ortho Pde4a Lyn i2d exp, ortho Dlg4 Lyn i2d exp, ortho G G Protein Irs2, RCG43183 Lyn ortho G G G G Znf423 Lyn ortho Itgb1 Lyn ortho G G G G Dok3 Lyn ortho Lyn Pik3r1 ortho G Lyn Ankrd54 ortho G Lyn Prkcq ortho G G G G Lyn Dok1 ortho Protein Ndfip2 Lyn ortho G G G G Prkcb Lyn ortho G G G Lyn Gp1bb ortho Csf3r_predicted Lyn ortho Lyn Hsp90b1 ortho G G G G Lyn Cd72 molecule, Protein Cd72 ortho Protein Fcar Lyn ortho Hnrnpk Lyn ortho Lyn Klf5 ortho G Lyn Fgfr1op ortho Lyn Folr1 ortho G G G G Protein E2f6 Lyn ortho G G G G Lrriq2_predicted Lyn ortho RGD1562292_predicted Lyn ortho Lyn Dbnl ortho G G G G Lyn Protein Ugp2, UDP-glucose pyrophosphorylase 2, UDP-glucose pyrophosphorylase 2, isoform CRA_b ortho G G G G Lyn Skap1 ortho Lyn Khdrbs1 ortho G G G G Lyn Pik3r3 ortho G RGD1306601_predicted Lyn ortho Protein Dennd2c Lyn ortho Csk Lyn ortho G G G G Lyn Gtpbp3 ortho G Lyn Epor ortho G G G Nfyb Lyn ortho Cdk4 Lyn ortho G G G G eplin Lyn ortho G G G G Lyn Adam15 ortho G G G G Lyn Mal ortho G G Lck Lyn ortho G G G G Fibroblast growth factor receptor Lyn ortho G G G G Lyn Myh9 ortho G G G G Prkcd Lyn ortho G G G G Lyn Rpl10 ortho Snca Lyn ortho G G Pde4d Lyn ortho G G Frs2_predicted Lyn ortho Lyn Hbs1l ortho G G G G Il2rb Lyn ortho G G G Cd37 Lyn ortho G Lyn Tada2a ortho G Stat3 Lyn ortho G G G G Lyn Protein Tmx1, Thioredoxin domain containing 1 ortho G G G G Mme Lyn ortho G G Lyn Ikbkg ortho Integrin beta Lyn ortho G G G LOC687009 Lyn ortho Yeats4_predicted Lyn ortho G G G G Ptk2 Lyn ortho G G G G Lyn Pak2 ortho G G G G Clec7a Lyn ortho Lyn Pag1 ortho Lyn Syk ortho G G G Lyn MGC125004 ortho Lyn Skap2 ortho G G G G Lyn Csf2rb ortho G G G Plcg2 Lyn ortho G Hoxc4 Lyn ortho Lyn Slc12a4 ortho G Cblc Lyn ortho Protein Cd19 Lyn ortho Lyn Tnk2 ortho G G Lyn Sphk1 ortho G G Protein Rassf8 Lyn ortho Rsafd1_predicted Lyn ortho Inpp5d Lyn ortho G G G G Lyn Protein Sphk2, RCG53912, isoform CRA_a, Sphingosine kinase 2 ortho G G G G Tp53 Lyn ortho G G G G Tubb4 Lyn ortho Lyn Cd36 ortho G G G Lyn Abi1 ortho G G G G B29/Ig-beta/CD79b, Cd79b molecule, immunoglobulin-associated beta, Protein Cd79b Lyn ortho G Lyn Pan2 ortho G G G G Gnb2l1 Lyn ortho G G G G Ptk2b Lyn ortho G Ptprc Lyn ortho G G G G Lyn Nmt1 ortho G G G G Matk Lyn ortho G Ribosomal protein S6 kinase Lyn ortho G G G G Lyn Ddx21 ortho Lyn Nphs1 ortho Ppp1r8_predicted Lyn ortho G G G G Insr Lyn ortho G G G G Plaur Lyn ortho G Trip10 Lyn ortho G G G G Lyn Fyn ortho G G Lyn Src ortho G Protein Dock8 Lyn ortho G G G G Lyn UPF0769 protein C21orf59 homolog ortho G G G Slc4a1 Lyn ortho G G Csnk2b Lyn ortho G G G G Lyn Rims2 ortho Lyn Khdrbs2 ortho Lyn Blnk ortho Zfp189_predicted Lyn ortho G G Lyn Shc1 ortho Protein Pik3cg Lyn ortho Protein Bank1, RCG28801 Lyn ortho Htr2a Lyn ortho G G G Ttyh3_predicted Lyn ortho G G G G Lyn Chst15 ortho Sh2d1a Lyn ortho Lyn Cttn ortho G G G G Lyn Gab2 ortho Actb Lyn ortho Lyn Rdx ortho G G G G Ccdc8 Lyn ortho G Map4k1_predicted Lyn ortho G Trim28 Lyn ortho G G G G Kynu Lyn ortho G G G Lyn Trpv4 ortho G Cd22_predicted Lyn ortho Cdh23 Lyn ortho Lyn Hdgfrp3 ortho Lyn Crebbp ortho G G G LOC100361515 Lyn ortho Lyn Fcgr2 ortho G G Ptpn6 Lyn ortho G G G Protein Dtx3 Lyn ortho G G G G Itpr1 Lyn ortho G G G G Tyrosine-protein kinase Lyn ortho G G G Protein Tpte2, Transmembrane phosphatase with tensin homology (Predicted) Lyn ortho Lyn RNCASP9 ortho G G G G Hsp90ab1 Lyn ortho G G G G Angpt2 Lyn ortho G G G p27Kip1 Lyn ortho G G G G Pak1 Lyn ortho G G G G Abl2_mapped Lyn ortho G G G G Lyn Unc119 ortho G G G G Lyn SLP76 ortho G Rnf180 Lyn ortho Lyn Ctla4 ortho Lyn Tsnax ortho G G G G Lyn Acsl3 ortho G G G G Rasa1 Lyn ortho G G G Fbxo28_predicted Lyn ortho Lyn Nkapl ortho Lat Lyn ortho G G Lyn Mcl1 ortho G G G G Ar Lyn ortho G G G Lyn Cblb ortho G G G Osbpl3 Lyn ortho G G G G Lyn Csf2ra ortho Lyn Erbb3 ortho G Lyn Ccnl2 ortho G G G G RGD1562795_predicted Lyn ortho Lyn Ocln ortho G G G Lyn Ero1l ortho G G G G Zcchc7 Lyn ortho Lyn Pecam1 ortho G G G G Lyn Sh2b2 ortho G Ywhae Lyn ortho G G G G Lyn Cnot10 ortho G G G G Lyn Neural cell expressed, developmentally down-regulated 9, Protein Nedd9, RCG44232, isoform CRA_b ortho G G G G Tnf Lyn ortho RGD1563421_predicted Lyn ortho Plcg1 Lyn ortho G G G G Protein Clnk Lyn ortho Lyn Hdac3 ortho G G G G Lamp2 Lyn ortho G G G G Elavl4 Lyn ortho G G G G ATP-binding cassette, sub-family E (OABP), member 1, Protein Abce1 Lyn ortho G G G G Lyn Lrriq3 ortho Lyn Il1b ortho G G G G Lyn Hematopoietic cell specific Lyn substrate 1, Protein Hcls1, RCG52681 ortho LOC687735 Lyn ortho Gria3 Lyn ortho G LOC301114 Lyn ortho Faslg Lyn ortho G G G Protein Tmem185a Lyn ortho G G G Klc2_predicted Lyn ortho G G G G Efs_predicted Lyn ortho Lyn Cdk2 ortho Spesp1 Lyn ortho Lyn Tmem17 ortho Rps6kb1 Lyn ortho G Rgs16 Lyn ortho Fcer1g Lyn ortho G G G G Scg3 Lyn ortho G Casp7 Lyn ortho G G G G Uhrf2_predicted Lyn ortho G G G G Dapp1_predicted Lyn ortho Lyn Uncharacterized protein C2orf47 homolog, mitochondrial ortho Cyp4v2 Lyn ortho G G G G Casp3 Lyn ortho G G G G Mapk1 Lyn ortho G G G G Lyn Bcar1 ortho G G G G Lyn Cbx6 ortho G G G Rbm11_predicted Lyn ortho Map3k3_predicted Lyn ortho G G G Il7r_predicted Lyn ortho Dok2_predicted Lyn ortho Ntrk1 Lyn ortho Mapk3 Lyn ortho G G G Lyn Sh2d4a ortho G G G G Ms4a1_predicted Lyn ortho Cpt1a Lyn ortho G G G G Lyn Sh3kbp1 ortho G G G G Cdk1 Lyn ortho G G Lyn Jak2 ortho G Met Lyn ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q07014 - 8761480 - X 2 P13386 Q07014 affinity chromatography technology 19356729 physical association X 2 Q07014 affinity chromatography technology 8627181 physical association X 2 Q07014 P82995 affinity chromatography technology 19356729 physical association X 2 Q07014 affinity chromatography technology 14531861 physical association X 2 Q07014 pull down 14531861 direct interaction X 2 Q63429 Q07014 affinity chromatography technology 22871113 physical association X 2 Q63429 Q07014 affinity chromatography technology 14531861 physical association X 2 Q63429 Q07014 two hybrid 11137137 direct interaction X 2 Q63429 Q07014 pull down 11137137 direct interaction X 2 Q07014 Q07014 enzymatic study 14604964 direct interaction X 2 Q07014 P06733-2 enzymatic study 14604964 direct interaction X 2 Q07014 H6UYS5 enzymatic study 11744621 direct interaction X 2 Q06649 Q07014 fluorescence microscopy 12709437 colocalization X 2 Q07014 Q1PS21 anti bait coimmunoprecipitation 23764002 physical association X 2 P28867 Q07014 coimmunoprecipitation 9692543 association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Lyn Cbl MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 14531861,8627181 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_334682|BIOGRID_335015|BIOGRID_334681 bait|prey|bait prey|bait|prey Ms4a2 Lyn MI:0004(affinity chromatography technology) 19356729 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_336910 bait prey Lyn Mcm7 MI:0007(anti tag coimmunoprecipitation) 23764002 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (intact) UniProt_184529 null prey Lyn Ubc MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 11137137,14531861,22871113 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_334696|BIOGRID_336834|BIOGRID_334695|BIOGRID_334679 bait|prey|bait|bait prey|bait|prey|prey Hsp90aa1 Lyn MI:0004(affinity chromatography technology) 19356729 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_336914 bait prey

PPI - HINT Gene A Gene B PMID Method Quality DLG4 LYN 14529711,14529711 0004,0019 LC LYN LYN 14604964 0415 LC LYN UBC 11137137,11137137 0018,0096 LC CBL LYN 14531861,14531861,8627181 0096,0004,0004 LC MS4A2 LYN 19356729 0004 LC DLG4 LYN 14529711,14529711 0004,0019 LC PDE4A LYN 8761480 0004 LC HSP90AA1 LYN 19356729 0004 LC LYN UBC 11137137,14531861,11137137 0018,0004,0096 LC LYN MCM7 23764002 0006 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q63429 Q07014 UBC LYN 0.671 22871113,11137137,14531861 Q07014 P13386 LYN MS4A2 0.21 19356729 Q07014 P28867 LYN PRKCD 0.21 9692543 Q07014 P82995 LYN HSP90AA1 0.21 19356729 Q07014 P06733 LYN ENO1 0.309 14604964 Q07014 P37840 LYN SNCA 0.309 11744621 Q07014 Q06649 LYN SH3BP2 0.126 12709437 Q07014 Q07014 LYN LYN 0.332 14604964 Q1PS21 Q07014 MCM7 LYN 0.126 23764002